Test Price
2,800 AED✅ Home Collection Available
NNT Gene Glucocorticoid Deficiency Type 4 (with/without Mineralocorticoid Deficiency) Genetic Test in UAE | 2800 AED | DHA-Licensed & ISO-Certified
Executive Summary & Core Metrics
Accuracy Guarantee: 99.9% Diagnostic Sensitivity via ISO 9001:2015 Certified NGS Processing. Premium Logistics: VIP Mobile Phlebotomy & Temperature-Controlled Cold-Chain Home Collection (8 AM – 11 PM). Clinical Guidance: Complimentary Telephonic Post-Test Result Interpretation by a DHA-Licensed Genetic Counsellor. Insurance: Direct Billing Verification via WhatsApp at +971 54 548 8731.
Test Overview & Methodology
This next-generation sequencing (NGS) test analyzes the entire coding region of the NNT gene to detect pathogenic variants responsible for familial glucocorticoid deficiency type 4 (FGD4), a rare autosomal recessive disorder that may also present with mineralocorticoid deficiency. It serves as a definitive molecular diagnostic tool for patients with unexplained primary adrenal insufficiency, guiding lifelong hormone replacement therapy and family screening.
| Feature | Our DHA-Accredited Test | Closest Alternative (Regional Hospital) |
|---|---|---|
| Methodology | High-coverage NGS (Illumina NovaSeq), full gene sequencing | Sanger sequencing (single-exon only) or limited panel |
| Diagnostic Sensitivity | >99.9% for SNVs & small indels; CNV analysis included | ~95% for targeted mutations only |
| Turnaround Time | 3–4 weeks | 6–10 weeks |
| Pre-test Genetic Counselling | Included (telephonic & pedigree chart) | Often not included or scheduled separately |
| Home Collection | VIP Mobile Phlebotomy & cold-chain, 8 AM–11 PM | Central lab visit required |
Physician Insight & Safety Protocols
"As a consultant medical geneticist, I recognize that receiving a genetic diagnosis for your child's adrenal condition can be overwhelming. The NNT test not only confirms the molecular basis of glucocorticoid deficiency but empowers you with a clear path for lifelong management and cascade screening. Please remember that all results must be correlated with clinical and biochemical findings before making any treatment changes."
— Lina Osama Zaki Quteineh, Consultant Medical Genetics, DHA Registration ID: 9294403
Medication Safety Advisory
Do not discontinue prescribed corticosteroid replacement therapy (e.g., hydrocortisone, fludrocortisone) or any other medication without explicit direction from your treating physician. Abrupt withdrawal can trigger a life-threatening adrenal crisis with hypotension, shock, and electrolyte disturbances.
Exclusion Criteria & Emergency Red Flags
- Exclusion: Individuals under 18 years without a legal guardian present to provide informed consent (as per Federal Decree-Law No. 4 of 2016 on Medical Liability).
- Exclusion: Patients currently in acute adrenal crisis; stabilization is required prior to elective genetic testing.
- Red Flag – Seek ER immediately: Sudden severe vomiting, diarrhea, profound weakness, confusion, severe hypotension, or loss of consciousness. These could indicate an adrenal crisis, which constitutes a medical emergency.
- Red Flag: Any suspicion of hyponatremia or hyperkalemia on recent lab work combined with fatigue—urgent evaluation is needed.
Patient FAQ & Clinical Guidance
1. What is the NNT gene test, and how does it diagnose glucocorticoid deficiency type 4?
The NNT gene test uses next-generation sequencing to detect pathogenic mutations in the nicotinamide nucleotide transhydrogenase gene, confirming familial glucocorticoid deficiency type 4 with or without mineralocorticoid involvement in symptomatic patients. This molecular diagnosis differentiates FGD4 from other forms of adrenal insufficiency and guides precise, lifelong hormone replacement.
2. Why is a genetic counselling session required before the blood draw?
Pre-test genetic counselling ensures that patients and families understand the inheritance pattern (autosomal recessive), the implications of a positive result for siblings, and the necessity of drawing a detailed pedigree chart to identify at-risk relatives who may benefit from carrier testing. This session is UAE regulatory best practice and maximizes the clinical utility of the NGS result.
3. How should I prepare for the NNT gene test, and can I take my usual medications?
No fasting or special preparation is needed; simply provide a blood sample via VIP Mobile Phlebotomy or at an accredited collection center. Continue all prescribed medications, especially corticosteroid or mineralocorticoid replacements, as instructed by your endocrinologist—never alter your dose before consulting your doctor. The test's accuracy is unaffected by drugs, food, or supplements.
UAE Regulatory & Data Privacy Adherence
This service complies with Federal Decree-Law No. 45 of 2021 on Personal Data Protection (PDPL) and Federal Law No. 2 of 2019 Concerning the Use of Information and Communication Technology in Health Fields. All genetic data is processed within the UAE with end-to-end encryption. Clinical safety and patient consent align with Federal Decree-Law No. 4 of 2016 on Medical Liability.
DHA Facility License: 1143 | DNA Labs UAE, Premises 105, Floor 1, Building 33, Dubai Healthcare City, Dubai, UAE.
Clinical & Logistical Metadata
| Test Name | NNT Gene Glucocorticoid Deficiency Type 4 (with/without Mineralocorticoid Deficiency) Genetic Test |
| Price (AED) | 2,800 AED |
| Turnaround Time | 3–4 weeks |
| Sample Type / Matrix | Peripheral Whole Blood (EDTA tube) |
| Methodology Used | Next-Generation Sequencing (NGS) – Full gene sequencing |
| ICD-10-CM Code | E27.1 (Primary adrenocortical insufficiency) |
| LOINC Code | 92713-0 (NNT gene full sequencing) |
| DHA Facility License & Lab Address | License: 1143 | DNA Labs UAE, Premises 105, Floor 1, Building 33, Dubai Healthcare City, Dubai, UAE |
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