Test Price
2,800 AED✅ Home Collection Available
MCCC2 Gene NGS Test for 3‑Methylcrotonyl‑CoA Carboxylase 2 Deficiency in UAE | 2800 AED | DHA Licensed
Executive Summary & Core Metrics
- Accuracy Guarantee: 99.9% Diagnostic Sensitivity via ISO 9001:2015 accredited NGS processing.
- Premium Logistics: Paid Hospital‑Grade Home Collection via ISO Certified Cold‑Chain Home Collection and VIP Mobile Phlebotomy.
- Clinical Guidance: Telephonic Post‑Test Clinical Guidance in result interpretation.
- Insurance: Direct Billing Verification via WhatsApp +971 54 548 8731.
Test Overview & Methodology
The MCCC2 Genetic Test uses Next‑Generation Sequencing (NGS) to detect pathogenic variants in the MCCC2 gene causing 3‑methylcrotonyl‑CoA carboxylase 2 deficiency, a rare autosomal recessive metabolic disorder. This test provides definitive molecular diagnosis, differentiating it from other organic acidurias and guiding appropriate management and family counselling.
| Feature | Our MCCC2 NGS Test | Traditional Enzyme Assay |
|---|---|---|
| Method | Next‑Generation Sequencing (NGS) | Liquid Chromatography‑Tandem Mass Spectrometry (LC‑MS/MS) |
| Diagnostic Precision | >99.9% Sensitivity & Specificity | Supportive; often requires confirmation |
| Turnaround Time | 3 to 4 Weeks | Variable (2‑6 weeks) |
| Clinical Utility | Definitive molecular diagnosis, carrier detection, family planning | Biochemical phenotype only |
Physician Insight & Safety Protocols
“As a medical geneticist, I understand the importance of definitive molecular diagnosis for rare metabolic disorders. This NGS test provides precise identification of MCCC2 mutations, but it is crucial to correlate results with clinical presentation and metabolic work‑up. Always consult your specialist before making any changes to treatment.”
— Lina Osama Zaki Quteineh | Consultant Medical Genetics | DHA Registration ID: 9294403
⚠️ Medication Safety Warning
Do not discontinue prescribed medication without consulting your doctor. Metabolic treatment plans (e.g., carnitine supplementation, dietary management) must be supervised by a specialist.
Exclusion Criteria & Emergency Red Flags
- Exclusion: Testing of asymptomatic minors without guardian consent and clinical suspicion is prohibited under UAE regulations in accordance with Federal Decree-Law No. 4 of 2016 on Medical Liability.
- Exclusion: Individuals unable to provide informed consent (e.g., cognitive impairment without legal representative).
- Red Flag: If the patient develops acute metabolic decompensation (vomiting, lethargy, seizures, or ketosis) while awaiting results, seek emergency medical attention immediately.
Patient FAQ & Clinical Guidance
1. What exactly does the MCCC2 NGS test diagnose?
A: This test sequences the MCCC2 gene to identify mutations with 99.9% accuracy, enabling precise diagnosis of 3‑methylcrotonyl‑CoA carboxylase 2 deficiency. Definitive molecular confirmation allows clinicians to differentiate MCCC2 deficiency from other organic acidurias, initiate correct management, and counsel families on inheritance patterns.
2. How is the sample collected and is home collection available?
A: A simple blood draw or FTA card sample is collected; our VIP mobile phlebotomy team arrives at your location within two hours. Samples accepted: 2‑5 mL EDTA whole blood, extracted DNA, or a single drop of blood on an FTA card. All collections follow ISO‑certified cold‑chain protocols.
3. What is the turnaround time and total cost with insurance?
A: Results are delivered in 3–4 weeks for 2800 AED; we verify your insurance benefits via WhatsApp before booking. The comprehensive report includes variant interpretation and clinical recommendations. Direct billing partnerships with major UAE insurers streamline the process.
Pre‑Information: A clinical history and a genetic counselling session to draw a pedigree chart of family members affected with 3‑methylcrotonyl‑CoA carboxylase 2 deficiency are required before sample submission. Our genetic counsellor will guide you through the process.
UAE Regulatory & Data Privacy Adherence
Regulatory Compliance & Data Privacy
All genetic testing at DNA Labs UAE is conducted in full compliance with Federal Decree-Law No. 45 of 2021 on Personal Data Protection (PDPL) and Federal Law No. 2 of 2019 Concerning the Use of Information and Communication Technology in Health Fields. Patient data is encrypted, access‑controlled, and never shared without explicit consent. The laboratory holds DHA Facility License Number 1143 and operates under strict ISO standards.
Clinical & Logistical Metadata
| Test Name | MCCC2 Gene NGS Test for 3‑Methylcrotonyl‑CoA Carboxylase 2 Deficiency |
| Price (AED) | 2,800 AED |
| Turnaround Time | 3 to 4 Weeks |
| Sample Type / Matrix | Peripheral Blood (Whole Blood or FTA Card) |
| Methodology Used | Next‑Generation Sequencing (NGS) |
| ICD-10-CM Code | E71.19 |
| LOINC Code | 35128-8 |
| DHA Facility License & Laboratory Address | License: 1143 | Premises 105, Floor 1, Building 33, Dubai Healthcare City, Dubai, UAE |
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