Test Price
2,800 AEDโ Home Collection Available
LCAT Gene Deficiency Genetic Test in UAE | 2,800 AED | DHA-Licensed Diagnostic Sequencing
Executive Summary & Core Metrics
This advanced NGS-based genetic test detects pathogenic mutations in the LCAT gene with diagnostic sensitivity exceeding 99.9%, performed at our ISO 9001:2015-accredited laboratory. The service includes VIP mobile phlebotomy, temperature-controlled cold-chain transport, and post-test telephonic clinical guidance for result interpretation. Insurance direct billing verification is available via WhatsApp at +971 54 548 8731.
- Accuracy Guarantee: 99.9% Diagnostic Sensitivity via ISO-Accredited NGS
- Premium Logistics: Paid Hospital-Grade Home Collection, ISO-Certified Cold-Chain Transport & VIP Mobile Phlebotomy
- Clinical Guidance: Telephonic Post-Test Clinical Guidance for Result Interpretation
- Insurance: Direct Billing Verification via WhatsApp +971 54 548 8731
Test Overview & Methodology
LCAT gene deficiency is a rare autosomal recessive disorder caused by loss-of-function mutations in the lecithin-cholesterol acyltransferase gene, resulting in corneal opacities, normochromic anemia, and progressive renal failure due to lipoprotein-X deposition. Our targeted NGS panel delivers comprehensive coverage of all coding exons, intronic boundaries, and known regulatory regions, enabling definitive molecular diagnosis for early intervention and informed family planning.
| Feature | Our LCAT Gene NGS Test | Closest Alternative (Biochemical / Sanger) |
|---|---|---|
| Precision | 99.9% analytical sensitivity for point mutations, indels, CNVs | Limited to known hotspots; ~85% sensitivity |
| Methodology | Next-Generation Sequencing (NGS) with full gene coverage | Sanger sequencing or LCAT enzyme activity assay |
| Turnaround Time | 3 to 4 Weeks | 4โ6 Weeks (biochemical) / 2โ3 Weeks (targeted) |
| Clinical Relevance | Comprehensive variant detection for diagnosis, carrier screening, and therapeutic decisions | May miss rare or novel mutations; less informative for genetic counseling |
Physician Insight & Safety Protocols
โThis NGS assay offers exceptional resolution for detecting LCAT mutations, but results must be correlated with fasting lipid profiles, ophthalmologic slit-lamp examination, and renal function markers. A negative sequencing result does not exclude other dyslipidemia syndromes; thorough pedigree analysis and clinical correlation remain indispensable for accurate counseling.โ โ Lina Osama Zaki Quteineh, Consultant Medical Genetics, DHA Registration ID: 9294403
Advisory Notice for Medication Continuity
Safety Exclusion Criteria & Emergency Red Flags
- Exclusion: Patients unable to provide informed consent, acute decompensated illness requiring urgent stabilization, or known interferences that could compromise DNA quality.
- Emergency Red Flags: Sudden vision loss, severe abdominal pain, dark urine (hemoglobinuria), rapid swelling of legs/feet โ seek immediate medical care regardless of test status. These may signal acute hemolytic crisis or acute kidney injury.
Patient FAQ & Clinical Guidance
1. What does the LCAT gene test detect?
This test analyzes the entire LCAT gene to identify disease-causing mutations responsible for lecithin-cholesterol acyltransferase deficiency. It screens coding regions and splice junctions via NGS, detecting point mutations, small insertions/deletions, and copy number variations. Results help confirm a clinical suspicion, guide early lipid management, and inform genetic counselling for family members.
2. How should I prepare for the test?
No fasting or special preparation is needed; simply provide a blood sample or DNA extracted from buccal swab. A prior genetic counselling session is highly recommended to draw a pedigree chart and discuss implications. Our mobile phlebotomy team will collect the sample at your convenience; you may continue regular medications unless instructed otherwise.
3. Is the LCAT gene test covered by UAE health insurance?
Most UAE insurers cover genetic testing for medically indicated conditions; our team verifies your policy via WhatsApp. Direct billing arrangements are available with many providers. To confirm coverage, send your insurance card copy to +971 54 548 8731. Reimbursement assistance is also offered.
UAE Regulatory & Data Privacy Adherence
- Licensed by Dubai Healthcare City Authority โ DHA Facility License No. 1143
- ISO 9001:2015 Certified (Cert: INT/EGQ/2509DA/3139)
- Compliant with Federal Decree-Law No. 45 of 2021 on Personal Data Protection (PDPL) for secure genetic data handling
- Adheres to Federal Law No. 2 of 2019 Concerning the Use of Information and Communication Technology in Health Fields
- Clinical safety and patient consent governed by Federal Decree-Law No. 4 of 2016 on Medical Liability
Clinical & Logistical Metadata
| Test Name | LCAT Gene Deficiency Genetic Test (NGS Sequencing) |
| Price (AED) | 2,800 AED |
| Turnaround Time | 3 to 4 Weeks |
| Sample Type / Matrix | Whole Blood or Buccal Swab (VIP Mobile Phlebotomy & Temperature-Controlled Cold-Chain Home Collection Available Daily 8 AM โ 11 PM) |
| Methodology Used | Next-Generation Sequencing (NGS) โ Full gene coverage including coding exons, splice junctions, and select regulatory regions |
| ICD-10-CM Code | E78.6 |
| LOINC Code | 50397-9 |
| DHA Facility License & Laboratory Address | DHA Facility License: 1143 | Premises 105, Floor 1, Building 33, Dubai Healthcare City, Dubai, UAE | Corporate Lab: DNA Labs UAE |
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Available in Arabic, English, Hindi & Urdu
ISMS 27001:2022
ISO Accredited
HIPAA
All reports reviewed by DHA-Certified physicians