Test Price
2,800 AED✅ Home Collection Available
IDUA Gene Hurler‑Scheie Syndrome Genetic Test in UAE | 2800 AED | 2026 DHA Guidelines
تحليل جين IDUA لمتلازمة هيرلر‑شي (Hurler‑Scheie) باستخدام التسلسل الجيني عالي الإنتاجية (NGS) في الإمارات | 2800 درهم | معتمد من هيئة الصحة بدبي
ملخص تنفيذي: يقدم اختبار تسلسل جين IDUA بتقنية NGS تشخيصاً دقيقاً لمتلازمة هيرلر‑شي (داء عديد السكاريد المخاطي النوع الأول) بنسبة دقة تشخيصية تصل إلى 99.9% عبر مختبراتنا المعتمدة وفق معايير ISO 9001:2015 وتحت إشراف هيئة الصحة بدبي (DHA).
- Accuracy Guarantee: 99.9% Diagnostic Sensitivity via ISO‑Accredited Sequencing on Illumina NovaSeq™ Platform.
- Premium Logistics: Paid Hospital‑Grade Home Collection via ISO Certified Cold‑Chain Home Collection & VIP Mobile Phlebotomy (8 AM – 11 PM).
- Clinical Guidance: Complimentary pre‑test genetic counseling session + post‑test telephonic interpretation by a Clinical Geneticist.
- Insurance: Direct Billing Verification via WhatsApp +971 54 548 8731.
Overview
This advanced NGS test sequences the entire IDUA gene to detect pathogenic variants causing Hurler‑Scheie syndrome, the intermediate form of Mucopolysaccharidosis type I (MPS I). يوفر هذا الاختبار دقة تشخيصية عالية ويُستخدم لتأكيد التشخيص أو فحص الحاملين للمرض.
| Feature | Our Test (IDUA NGS) | Closest Alternative (α‑L‑Iduronidase Enzyme Assay) |
|---|---|---|
| Precision | 99.9% sensitivity for point mutations, small indels, and splice variants | ~80% sensitivity; cannot detect all pathogenic variants or carrier status |
| Method | Full‑gene Next‑Generation Sequencing (Illumina, 100× depth) | Fluorometric enzyme activity assay |
| Turnaround | 3 – 4 Weeks | 1 – 2 Weeks |
| Diagnostic Scope | Identifies carrier status, prognostic subtypes, and guides family screening | Only confirms enzyme deficiency; cannot differentiate MPS I subtypes (Hurler, Hurler‑Scheie, Scheie) |
Who Orders This Test (Clinical Intent)
The IDUA NGS test is typically initiated by a DHA‑licensed specialist after comprehensive clinical evaluation:
- Clinical Geneticist: To confirm a molecular diagnosis in patients with dysostosis multiplex, corneal clouding, and organomegaly suggestive of MPS I.
- Pediatric Metabolic Disease Consultant: For early‑onset cases and pre‑symptomatic family screening.
- Genetic Counselor: For pre‑conception carrier testing and risk assessment in extended families.
Physician Insight & Safety Protocol
“While this NGS assay provides unparalleled molecular resolution, the result must always be correlated with clinical phenotype and enzyme activity. A negative report in a highly suggestive case still warrants further investigation, including deletion/duplication analysis and urine glycosaminoglycan quantification. Every patient deserves a holistic metabolic workup – never rely solely on a single genetic test.”
– Dr. Prabhakar Reddy, DHA License No. 61713011, Consultant Clinical Geneticist
⚠️ Medication Warning
Do not discontinue or adjust any prescribed medication, including enzyme replacement therapy (laronidase), without consulting your supervising physician.
Patient Safety: Exclusion Criteria & Emergency Red Flags
Exclusion Criteria (Do Not Proceed with Home Collection)
- Acute febrile illness or systemic infection
- Severe anemia or bleeding diathesis
- Inability to provide informed consent (patient or legal guardian)
- Current high‑risk pregnancy without prior genetic counseling
- Venous access too poor for 3 mL whole blood collection
Emergency Red Flags – Direct to ER Immediately
- Sudden onset of stridor, cyanosis, or severe respiratory distress
- Acute cardiac decompensation or arrhythmia
- New‑onset seizures or loss of consciousness
- Severe abdominal distension with signs of organ rupture
- Acute psychiatric crisis or suicidal ideation
Patient FAQ & Clinical Guidance
1. What is the IDUA gene NGS test and who needs it?
The IDUA gene NGS test sequences the entire IDUA gene to detect pathogenic variants causing Hurler‑Scheie syndrome (MPS I), aiding diagnosis and carrier screening.
الاختبار مخصص للأفراد الذين تظهر عليهم أعراض سريرية توحي بمتلازمة هيرلر‑شي أو الذين لديهم تاريخ عائلي للمرض.
2. How is the sample collected and is there a home service?
We offer painless home blood collection via DHA‑licensed phlebotomists using a simple venipuncture or FTA card, with secure cold‑chain transport to our ISO‑certified lab.
تتوفر خدمة سحب الدم المنزلي من خلال ممرضين مرخصين من هيئة الصحة، مع نقل العينة في ظروف مبردة إلى المختبر.
3. What is the turnaround time and does the price include genetic counseling?
The test reports within 3 to 4 weeks, and the package includes a pre‑test genetic counseling session and post‑ clinical interpretation by a specialist.
تصدر النتيجة في غضون 3 إلى 4 أسابيع، وتشمل الحزمة جلسة استشارة وراثية قبل الفحص وتفسير النتائج بعد الفحص من قبل أخصائي.
UAE Regulatory Compliance
This service strictly adheres to Federal Decree‑Law No. 41 of 2024 (Art. 87) on Medical Liability, the 2026 Communicable Diseases Surveillance Law for minors, and the UAE Personal Data Protection Law (PDPL). All genetic data is stored within UAE sovereign cloud servers and handled with explicit consent.
دعم ثنائي اللغة متاح
التحقق من التغطية التأمينية
Check Insurance Coverage Instantly
Stop the guesswork. Send a photo of your Insurance Card and Doctor's Prescription to our DHA-Certified Verification Team on WhatsApp.
توقف عن التخمين. أرسل صورة من بطاقة التأمين ووصفة الطبيب إلى فريق التحقق المعتمد من هيئة الصحة بدبي عبر الواتساب. احصل على تحديث الحالة في دقائق.
Available in Arabic, English, Hindi & Urdu
ISMS 27001:2022
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All reports reviewed by DHA-Certified physicians