Test Price
2,800 AED✅ Home Collection Available
GNAS Gene Progressive Osseous Heteroplasia (POH) Genetic Test in UAE | 2,800 AED | DNA Labs UAE
Executive Summary & Core Metrics
- 99.9% Diagnostic Sensitivity — ISO 9001:2015 accredited NGS processing with full exon coverage.
- Expert Oversight — Supervised and interpreted by Lina Osama Zaki Quteineh, Consultant Medical Genetics (DHA Registration ID: 9294403).
- Premium Logistics — VIP Mobile Phlebotomy & Temperature-Controlled Cold-Chain Home Collection available daily from 8 AM to 11 PM.
- Clinical Guidance — Telephonic post-test interpretation by DHA-licensed genetics specialists.
- Insurance Verification — Direct billing check via WhatsApp +971 54 548 8731.
Test Overview & Methodology
The GNAS Gene Progressive Osseous Heteroplasia (POH) NGS Genetic Test is a comprehensive molecular analysis designed to detect pathogenic variants in the GNAS gene. This test provides definitive confirmation of Progressive Osseous Heteroplasia, a rare genetic disorder characterized by ectopic bone formation in the skin and soft tissues. The results facilitate accurate differentiation from similar heterotopic ossification syndromes and guide informed clinical surveillance for potential endocrine, dermatological, and orthopedic complications.
| Parameter | Our Test (Premium Pathway) | Closest Alternative |
|---|---|---|
| Technology | Next-Generation Sequencing (NGS) with full exon coverage | Sanger sequencing (single-exon resolution) |
| Precision | ≥99.9% sensitivity; detects SNVs, small indels, and pathogenic variants | High specificity but limited to pre-known hotspots |
| Turnaround Time | 3–4 Weeks | 6–8 Weeks |
| Sample Types | Whole Blood, Extracted DNA, or FTA Card | Whole blood only |
| Genetic Counseling | Pre- and post-test session included with pedigree analysis | Not included or optional extra |
Physician Insight & Safety Protocols
Lina Osama Zaki Quteineh | Consultant Medical Genetics | DHA Registration ID: 9294403
“The clinical presentation of Progressive Osseous Heteroplasia can be challenging to differentiate from other ectopic ossification syndromes. This comprehensive NGS analysis of the GNAS gene provides the definitive molecular diagnosis required to guide appropriate dermatological, orthopedic, and oncological surveillance strategies. It is essential to integrate this genetic finding with the complete clinical and familial context to ensure optimal patient management.”
Clinical Advisory & Medication Safety
Do not discontinue or alter any prescribed medications without consulting your treating physician. Genetic test results provide diagnostic information and are not a replacement for current therapeutic regimens or regular clinical follow-ups.
Safety Exclusion & Emergency Red Flags
- Exclusion Criteria: Active febrile illness, severe coagulopathy, or inability to provide informed consent in accordance with Federal Decree-Law No. 4 of 2016 on Medical Liability. Discuss needle‑phobia alternatives with our phlebotomy team.
- Red Flags (Seek Immediate Medical Care): Rapidly expanding painful mass at a heterotopic ossification site, sudden joint contracture, or acute neurological symptoms (suggesting spinal cord compression). This test is not an emergency diagnostic tool.
Patient FAQ & Clinical Guidance
1. What is the GNAS gene NGS test and why is it recommended?
This advanced NGS test detects pathogenic GNAS mutations causing Progressive Osseous Heteroplasia, a rare bone-skin disorder. It confirms the diagnosis at the molecular level, differentiates POH from similar conditions like McCune‑Albright syndrome, and enables early surveillance for complications such as endocrine abnormalities or malignant transformation.
2. How is the sample collected and what are the pre‑test requirements?
A temperature-controlled cold-chain phlebotomist collects whole blood, extracted DNA, or a single FTA card drop at your home via our VIP Mobile Phlebotomy service. Pre‑test essentials include a completed clinical history form, a compulsory genetic counselling session (arranged as a tele-consultation), and a pedigree chart of affected family members. No fasting or medication adjustments are required.
3. How long do results take and will I receive interpretation support?
Your comprehensive NGS report is ready within 3 to 4 weeks, containing the full clinical interpretation and variant classification. A DHA‑licensed Consultant Medical Genetics specialist will hold a telephonic post‑test session to explain the findings, implications for family members, and recommended surveillance schedules. Continuous support is available via WhatsApp at +971 54 548 8731.
UAE Regulatory & Data Privacy Adherence
DNA Labs UAE operates in full compliance with the UAE legislative framework for health data and personal privacy. All genetic information is securely encrypted, access-controlled, and processed solely for validated diagnostic purposes under the supervision of DHA-licensed specialists.
- Data Protection: Federal Decree-Law No. 45 of 2021 on Personal Data Protection (PDPL).
- Health Information Governance: Federal Law No. 2 of 2019 Concerning the Use of Information and Communication Technology in Health Fields.
Clinical & Logistical Metadata
| Test Name | GNAS Gene Progressive Osseous Heteroplasia (POH) NGS Genetic Test |
| Price (AED) | 2,800 AED |
| Turnaround Time | 3–4 Weeks |
| Sample Type / Matrix | Whole Blood, Extracted DNA, or FTA Card |
| Methodology Used | Next-Generation Sequencing (NGS) |
| ICD-10-CM Code | M61.50, Q87.8, Z13.79 |
| LOINC Code | 81660-2 |
| DHA Facility License & Address | License: 1143 | Premises 105, Floor 1, Building 33, Dubai Healthcare City, Dubai, UAE |
دعم ثنائي اللغة متاح
التحقق من التغطية التأمينية
Check Insurance Coverage Instantly
Stop the guesswork. Send a photo of your Insurance Card and Doctor's Prescription to our DHA-Certified Verification Team on WhatsApp.
توقف عن التخمين. أرسل صورة من بطاقة التأمين ووصفة الطبيب إلى فريق التحقق المعتمد من هيئة الصحة بدبي عبر الواتساب. احصل على تحديث الحالة في دقائق.
Available in Arabic, English, Hindi & Urdu
ISMS 27001:2022
ISO Accredited
HIPAA
All reports reviewed by DHA-Certified physicians