Test Price
2,800 AED✅ Home Collection Available
GCSH Gene Glycine Encephalopathy Genetic Test in Dubai, UAE | 2,800 AED
Executive Summary & Core Metrics
✅ Accuracy Guarantee: 99.9% diagnostic sensitivity via ISO 9001:2015 accredited NGS sequencing with Sanger confirmation.
🚑 Premium Logistics: VIP Mobile Phlebotomy & Temperature-Controlled Cold-Chain Home Collection (available daily 8 AM – 11 PM).
📞 Clinical Guidance: Post-test telephonic guidance by a Consultant Medical Geneticist for result interpretation.
💳 Insurance: Direct billing verification via WhatsApp +971 54 548 8731.
Test Overview & Methodology
The GCSH Gene Glycine Encephalopathy NGS test uses next-generation sequencing to detect pathogenic variants in the glycine cleavage system H protein gene, enabling definitive molecular diagnosis of nonketotic hyperglycinemia (NKH). This comprehensive analysis covers all coding exons plus at least 10 bp of flanking intronic regions, ensuring high diagnostic yield.
| Feature | Our GCSH NGS Test | Closest Alternative |
|---|---|---|
| Test Type | Comprehensive full-gene sequencing | Targeted mutation panel / biochemical assay |
| Technology | Next-Generation Sequencing (NGS) with Sanger confirmation | Sanger sequencing / enzymatic activity assay |
| Turnaround Time | 3 – 4 Weeks | 4 – 6 Weeks (often with reflex to biochemical) |
| Diagnostic Sensitivity | 99.9% (all coding exons ±10 bp flanking intronic) | Limited to hotspot regions or biochemical surrogate |
| Accreditation | ISO 9001:2015, DHA Licensed Facility 1143 | Often lacks UAE-specific DHA genetic licence |
Physician Insight & Safety Protocols
“A positive GCSH genetic result must be integrated with metabolic profiling and neurological imaging; molecular diagnosis provides clarity but does not replace comprehensive clinical evaluation. I strongly recommend pre- and post-test genetic counselling by a qualified medical geneticist or neurologist to interpret variant pathogenicity within the patient’s full clinical context.”
— Lina Osama Zaki Quteineh, Consultant Medical Genetics, DHA Registration ID: 9294403
Advisory & Medication Notice
Do not discontinue or alter prescribed medication without consulting your doctor. The genetic result is intended to guide clinical management, not to replace ongoing therapy. Always discuss any changes with your treating physician.
Exclusion Criteria & Emergency Red Flags
- Exclusion: Patients who have received an allogeneic bone marrow transplant within the last 12 months (donor DNA interference). Test is not indicated for forensic or legal parentage without chain-of-custody collection.
- Emergency: If you experience acute worsening of seizures, marked lethargy, or severe hypotonia, seek emergency medical care immediately – these signs may indicate metabolic decompensation independent of test results.
Patient FAQ & Clinical Guidance
1. What is the purpose of the GCSH gene test?
The test identifies pathogenic variants in the GCSH gene that cause glycine encephalopathy (nonketotic hyperglycinemia), enabling accurate molecular diagnosis, family planning, and informed clinical management.
2. How should I prepare for this genetic test?
No special preparation such as fasting is required. However, a detailed clinical history and a pre-test genetic counselling session to construct a three-generation pedigree must be completed before sample collection.
3. What does a ‘variant of uncertain significance’ (VUS) mean?
A VUS is a genetic change where current evidence is insufficient to classify it as benign or disease-causing. Periodic re‑analysis as scientific knowledge advances may reclassify the variant; your genetic counsellor will guide follow-up.
4. Is the test covered by health insurance in Dubai?
Coverage depends on your individual policy. DNA Labs UAE offers direct billing verification – contact our insurance team via WhatsApp at +971 54 548 8731 to check eligibility and pre-authorization.
5. Can this test be performed on samples from outside the UAE?
Yes, we accept international shipments for archival tissue specimens (FFPE blocks or slides) and peripheral blood. A secure medical courier service can be arranged for solid tissue retrieval; contact our logistics team for details.
UAE Regulatory & Data Privacy Adherence
Data Privacy & Security: This genetic testing service strictly complies with Federal Decree‑Law No. 45 of 2021 on Personal Data Protection (PDPL) and Federal Law No. 2 of 2019 Concerning the Use of Information and Communication Technology in Health Fields.
Clinical Safety & Consent: All procedures follow Federal Decree‑Law No. 4 of 2016 on Medical Liability, ensuring informed consent and patient safety. Laboratory operations are conducted under DHA Facility Licence 1143 and ISO 9001:2015 accreditation.
Clinical & Logistical Metadata
| Test Name | GCSH Gene Glycine Encephalopathy Genetic Test (NGS) |
| Price (AED) | 2,800 |
| Turnaround Time | 3–4 weeks |
| Sample Type / Matrix | Peripheral whole blood (EDTA) – standard venipuncture; VIP Home Phlebotomy available |
| Methodology Used | Next-Generation Sequencing (NGS) with Sanger confirmation; full coding exons ±10 bp intronic flanking |
| ICD-10-CM Code | E72.51 (Nonketotic hyperglycinemia) |
| LOINC Code | 82325-9 (Glycine cleavage system H protein gene mutation detection) |
| DHA Facility License & Address | 1143 | DNA Labs UAE, Premises 105, Floor 1, Building 33, Dubai Healthcare City, Dubai, UAE |
دعم ثنائي اللغة متاح
التحقق من التغطية التأمينية
Check Insurance Coverage Instantly
Stop the guesswork. Send a photo of your Insurance Card and Doctor's Prescription to our DHA-Certified Verification Team on WhatsApp.
توقف عن التخمين. أرسل صورة من بطاقة التأمين ووصفة الطبيب إلى فريق التحقق المعتمد من هيئة الصحة بدبي عبر الواتساب. احصل على تحديث الحالة في دقائق.
Available in Arabic, English, Hindi & Urdu
ISMS 27001:2022
ISO Accredited
HIPAA
All reports reviewed by DHA-Certified physicians