Test Price
2,800 AEDโ Home Collection Available
CLCN5 Gene Dent Disease โ Next Generation Sequencing (NGS) Test in Dubai, UAE
Executive Summary & Core Metrics
Accuracy: 99.9% diagnostic sensitivity via ISO-accredited NGS processing with full exon and splice site coverage.
Logistics: VIP Mobile Phlebotomy and temperature-controlled cold-chain home collection available daily from 8 AM to 11 PM.
Clinical Guidance: Telephonic post-test interpretation and genetic counselling session included in the package.
Insurance: Direct billing verification via WhatsApp at +971 54 548 8731.
Price: 2,800 AED inclusive of genetic counselling and pedigree charting.
Test Overview & Methodology
The CLCN5 gene Dent disease NGS test provides definitive molecular diagnosis for Dent disease, an X-linked recessive renal tubular disorder that predominantly affects males and can present with low-molecular-weight proteinuria, hypercalciuria, nephrocalcinosis, and progressive kidney failure. This test employs high-depth next generation sequencing to detect pathogenic variants across all coding exons and splice-site junctions of the CLCN5 gene, enabling early intervention, informed family planning, and personalised management by nephrologists and clinical geneticists.
| Feature | Our CLCN5 NGS Test | Conventional Sequencing Alternative |
|---|---|---|
| Precision | 99.9% diagnostic sensitivity; full exon and splice site coverage | Limited to known hotspots; lower mutation detection rate |
| Methodology | Next Generation Sequencing (NGS) โ high-depth, clinically validated | Sanger sequencing or targeted panel; may miss novel variants |
| Turnaround | 3 to 4 Weeks with rapid reporting option available | Often 6โ8 weeks; limited local availability |
Physician Insight & Safety Protocols
โThis CLCN5 genetic test delivers precise molecular evidence for Dent disease, yet its clinical value depends on correlation with your full history, family pedigree, and biochemical markers of kidney function. I strongly recommend reviewing your results with a qualified nephrologist or genetic counsellor, as not every sequence variant causes disease. Never adjust your therapy without direct medical consultation.โ
โ Lina Osama Zaki Quteineh, Consultant Medical Genetics | DHA Registration ID: 9294403
โ ๏ธ Critical Advisory
Do not discontinue any prescribed medication without consulting your doctor.
- Exclusion Criteria: This test is not suitable for individuals with acute febrile illness, active bleeding disorders, or inability to provide a venous blood sample. It is not a substitute for specialist nephrology consultation.
- Emergency Red Flags: If you experience sudden severe flank pain, visible blood in urine, or signs of acute kidney obstruction (nausea, vomiting, decreased urination), proceed immediately to the nearest emergency department.
Clinical safety and patient consent procedures comply with Federal Decree-Law No. 4 of 2016 on Medical Liability.
Patient FAQ & Clinical Guidance
1. What is the CLCN5 gene Dent disease NGS test?
The CLCN5 gene Dent disease NGS test is a comprehensive genetic analysis that sequences all coding regions of the CLCN5 gene to identify pathogenic mutations causing Dent disease, a rare X-linked kidney disorder. This test helps confirm the diagnosis in patients with low-molecular-weight proteinuria, hypercalciuria, nephrocalcinosis, or a family history of kidney stones. It is performed on DNA extracted from a standard blood sample, FTA card, or one-drop blood sample and typically reports within 3 to 4 weeks.
2. Who should consider undergoing this genetic test?
Males with early-onset kidney stones, unexplained hypophosphatemic rickets, or a strong maternal family history of Dent disease are prime candidates, since the X-linked recessive pattern predominantly affects males while carrier females may also develop mild symptoms. Additionally, asymptomatic female relatives seeking carrier status clarification and parents of an affected child planning future pregnancies benefit from this test for informed reproductive decisions.
3. How should I prepare for the test and what does it cost?
No dietary or medication fasting is required for the standard blood draw, but please inform the phlebotomist about any blood-thinning medications you are taking. A mandatory pre-test genetic counselling session and pedigree charting of affected family members are included in the package. The total cost is 2,800 AED, with insurance direct billing available after verification via WhatsApp at +971 54 548 8731.
4. What happens after I receive my results?
A detailed clinical report will be issued and explained during a telephonic post-test counselling session with our genetics team. Your referring physician will also receive a copy for integration into your overall care plan. Further specialist referrals to nephrology, urology, or metabolic medicine can be arranged as needed.
UAE Regulatory & Data Privacy Adherence
Data Protection & Health Information Governance: This service operates in full compliance with Federal Decree-Law No. 45 of 2021 on Personal Data Protection (PDPL) and Federal Law No. 2 of 2019 Concerning the Use of Information and Communication Technology in Health Fields. Your genetic data is encrypted, access-controlled, and processed exclusively within ISO 9001:2015 certified facilities (Cert: INT/EGQ/2509DA/3139). All biological specimens are transported using validated cold-chain logistics to ensure sample integrity from collection to laboratory processing.
Clinical & Logistical Metadata
| Test Name | CLCN5 Gene Dent Disease โ Next Generation Sequencing (NGS) Test |
| Price (AED) | 2,800 AED |
| Turnaround Time | 3 to 4 Weeks |
| Sample Type / Matrix | Whole Blood (Peripheral), FTA Card, or One-Drop Blood Sample |
| Methodology Used | Next Generation Sequencing (NGS) โ Full Exon & Splice Site Coverage |
| ICD-10-CM Code | N25.8 |
| LOINC Code | 93935-7 |
| DHA Facility License & Address | License No. 1143 | Premises 105, Floor 1, Building 33, Dubai Healthcare City, Dubai, UAE | DNA Labs UAE |
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ISMS 27001:2022
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All reports reviewed by DHA-Certified physicians