Test Price
2,800 AED✅ Home Collection Available
CD40 Gene Immunodeficiency Type 3 (Hyper-IgM Syndrome) – Genetic Test in UAE | 2800 AED | 2026 DHA Guidelines
تحليل جين CD40 لنقص المناعة من النوع 3 مع فرط الغلوبولين المناعي M – فحص الحمض النووي بتقنية التسلسل الجيني المتقدم في الإمارات | 2800 درهم | معتمد من هيئة الصحة بدبي
ضمان الدقة: حساسية تشخيصية بنسبة 99.9% عبر معالجة معتمدة بمعيار ISO.
الخدمات اللوجستية المتميزة: سحب عينات منزلية على مستوى المستشفيات عبر خدمة VIP المتنقلة، مع سلسلة تبريد معتمدة.
الإرشاد السريري: استشارة هاتفية بعد الفحص لتفسير النتائج.
التأمين: تحقق مباشر من التغطية التأمينية عبر واتساب +971 54 548 8731.
Test Overview
An advanced Next-Generation Sequencing (NGS) analysis of the entire coding region of the CD40 gene to diagnose autosomal recessive Hyper-IgM syndrome type 3, characterized by severe immunodeficiency with normal or elevated IgM and low IgG, IgA, IgE, leading to recurrent infections and autoimmunity.
تحليل جيني شامل بتقنية التسلسل من الجيل التالي لتشخيص متلازمة فرط الغلوبولين المناعي M من النوع 3 المتنحية، المرتبطة بنقص المناعة الشديد وارتفاع IgM.
| Feature | Our Test (CD40 NGS – DHA/MOHAP Standard) | Closest Alternative (Targeted Genotyping) |
|---|---|---|
| Precision | 99.9% diagnostic sensitivity; detects all SNVs, indels, CNVs across the entire CD40 gene | Limited to pre-defined common mutations; may miss rare or private variants |
| Methodology | NGS (Illumina® platform) with Sanger validation, ISO 9001:2015 lab | PCR + RFLP or SSP; no sequence-level resolution |
| Turnaround Time | 3 to 4 Weeks (express available) | 5–7 days for limited panel, but often requires second test for full sequencing |
Physician Insight & Safety Protocol
“I understand the anxiety associated with suspected primary immunodeficiency. This NGS test provides definitive molecular diagnosis for CD40 deficiency, enabling early targeted therapy such as immunoglobulin replacement or haematopoietic stem cell transplantation. However, a negative result does not exclude other immunodeficiencies; clinical correlation with immunological workup remains essential.”
– Dr. Prabhakar Reddy, DHA License: 61713011
⚠️ Medication Warning:
Do not discontinue any prescribed immunosuppressive, antibiotic, or immunoglobulin therapy without explicit instruction from your treating physician. Abrupt changes may precipitate severe infections.
Safety Exclusion Criteria & Red Flags
- Patients currently on anticoagulants (e.g., warfarin, heparin) require physician clearance before blood draw.
- Severe thrombocytopenia or active bleeding disorder: risk of haematoma.
- Recent (within 4 weeks) haematopoietic stem cell transplant may cause donor chimerism confounding results.
- Seek emergency care if post-collection: fever >38.5°C, uncontrolled bleeding, or signs of local infection.
- Minors must be accompanied by a legal guardian (UAE CDS Law 2026).
Frequently Asked Questions
What is the clinical sensitivity of this CD40 NGS test for Hyper-IgM type 3?
This ISO-certified NGS assay achieves >99% analytical sensitivity and specificity for all CD40 coding variants, providing a definitive molecular diagnosis in patients with typical immunological phenotype.
يحقق هذا الفحص حساسية تحليلية تزيد عن 99% لجميع طفرات جين CD40 المرتبطة بالمرض، مما يتيح تشخيصًا جزيئيًا دقيقًا.
Can the test be performed on a dried blood spot from a newborn?
Yes, we accept FTA card microsamples—one drop of blood is sufficient for whole gene sequencing, enabling minimally invasive collection in neonates and remote areas across the UAE.
نعم، نقبل عينات بطاقة FTA من الرضّع؛ قطرة دم واحدة تكفي لتسلسل الجين بالكامل، مما يسهل التشخيص المبكر.
How soon can I receive my results, and is genetic counselling included?
Results are delivered in 3–4 weeks via secure portal; a complimentary post- genetic counselling session with a DHA-licensed professional is scheduled to interpret findings and discuss family planning options.
تصدر النتائج خلال 3-4 أسابيع مع جلسة استشارة وراثية مجانية بعد الفحص مع أخصائي مرخص من هيئة الصحة بدبي.
UAE Regulatory & Accreditation Compliance
- Licensed by Dubai Health Authority (Facility License: 9834453) and compliant with Federal Decree-Law No. 41 of 2024, Art. 87 governing genetic testing and health data.
- Fully adheres to UAE Child Data & Safety Law (CDS 2026) for minors and UAE Personal Data Protection Law (PDPL) – patient data sovereignty guaranteed.
- ISO 9001:2015 Certified (Cert: INT/EGQ/2509DA/3139) – ensuring processes meet international quality management standards.
- All sample logistics follow validated cold-chain protocols; home collection available daily 8 AM – 11 PM.
دعم ثنائي اللغة متاح
التحقق من التغطية التأمينية
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Stop the guesswork. Send a photo of your Insurance Card and Doctor's Prescription to our DHA-Certified Verification Team on WhatsApp.
توقف عن التخمين. أرسل صورة من بطاقة التأمين ووصفة الطبيب إلى فريق التحقق المعتمد من هيئة الصحة بدبي عبر الواتساب. احصل على تحديث الحالة في دقائق.
Available in Arabic, English, Hindi & Urdu
ISMS 27001:2022
ISO Accredited
HIPAA
All reports reviewed by DHA-Certified physicians