Test Price
2,800 AED✅ Home Collection Available
LHCGR Gene Leydig Cell Hypoplasia Type 1 Genetic Test in UAE | 2800 AED | 2026 DHA Guidelines
تحليل الجين LHCGR لنقص تنسج خلايا لايديغ من النوع الأول في الإمارات | 2800 درهم | معتمد من هيئة الصحة بدبي
Executive Summary – Clinical Confidence, UAE Logistics
- Accuracy Guarantee: 99.9% Diagnostic Sensitivity via ISO 9001:2015 Accredited NGS processing.
- Premium Logistics: Paid Hospital-Grade Home Collection via ISO Certified Cold-Chain Home Collection and VIP Mobile Phlebotomy.
- Clinical Guidance: Telephonic Post-Test Clinical Guidance in result interpretation.
- Insurance: Direct Billing Verification via WhatsApp +971 54 548 8731.
- الملخص التنفيذي: فحص وراثي عالي الدقة لتأكيد تشخيص نقص تنسج خلايا لايديغ بدعم من الجمع المنزلي المعتمد والاستشارة الوراثية.
Test Overview
The LHCGR (Luteinizing Hormone/Choriogonadotropin Receptor) gene NGS test uncovers pathogenic variants causing Leydig cell hypoplasia type 1—a rare autosomal recessive 46,XY disorder of sex development that leads to complete lack of masculinization. This definitive molecular diagnosis guides sex assignment decisions, hormone therapy planning, and genetic counselling for affected families. يُقدم الفحص تحليلاً دقيقاً للطفرات الجينية ويُستخدم لتأكيد التشخيص التفريقي لحالات الأعضاء التناسلية المبهمة لدى المواليد الذكور.
| Parameter | Our LHCGR NGS Test | Hormonal Profiling + Imaging |
|---|---|---|
| Diagnostic Precision | 99.9% sensitivity for LHCGR mutations | Suggestive but non-confirmatory; cannot differentiate from other androgen synthesis defects |
| Methodology | Next Generation Sequencing (NGS) with Sanger validation | LC-MS/MS for testosterone/DHT ratio, ultrasound/MRI for gonads |
| Turnaround Time | 3 to 4 Weeks | 3–5 working days (but inconclusive) |
| Clinical Utility | Identifies carrier status, recurrence risk, and definitive diagnosis | Limited to phenotypic description |
Physician Insight & Safety Protocol
Dr. PRABHAKAR REDDY, DHA License 61713011, notes:
“As a specialist in reproductive genetics, I understand the profound emotional weight a Leydig cell hypoplasia diagnosis carries for families. This NGS test provides a crystal-clear molecular confirmation, yet it must always be correlated with a full endocrine workup—testosterone, LH, AMH, and imaging—before any irreversible clinical decisions are made. My team ensures post-test counselling so you are never alone in deciphering the results.”
Patient Safety – Exclusion Criteria & Emergency Red Flags
- Exclusion Criteria: Individuals who have received an allogeneic bone marrow or stem cell transplant within the previous 12 months should opt for buccal swab DNA collection to avoid donor DNA contamination.
- Exclusion Criteria: Active severe bleeding disorders; discuss with your phlebotomist.
- ER Red Flags: If your newborn displays severe vomiting, dehydration, lethargy, or shock alongside ambiguous genitalia, seek immediate ER care—not solely for this test. While Leydig cell hypoplasia itself does not cause adrenal crisis, these symptoms warrant urgent exclusion of congenital adrenal hyperplasia (CAH) or salt-wasting disorders.
- ER Red Flags: Sudden testicular pain or swelling in a pubertal-age child with known Leydig cell hypoplasia could indicate germ cell tumor risk and requires urgent urological assessment.
Patient FAQ & Clinical Guidance
1. What is LHCGR gene Leydig cell hypoplasia type 1 and who should be tested?
The LHCGR gene mutation causes complete Leydig cell hypoplasia type 1—a condition where XY fetuses develop female external genitalia despite normal testes. This definitive genetic test identifies the mutation and is recommended for newborns with ambiguous genitalia, family history of sex development disorders, or confirmation before sex assignment surgery.
طفرة جين LHCGR تؤدي إلى نقص تنسج خلايا لايديغ الكامل، مما يسبب أعضاء تناسلية أنثوية لدى الأجنة الذكور (XY). يُوصى بالفحص للمواليد المصابين بغموض الأعضاء التناسلية أو التاريخ العائلي لاضطرابات التطور الجنسي.
2. How is the NGS test performed and what is the turnaround time?
A single blood draw (or one drop on an FTA card) is collected by a certified phlebotomist at your home. DNA is then extracted and sequenced using high-coverage NGS with Sanger validation of pathogenic variants. The laboratory turnaround time is 3 to 4 weeks from sample receipt.
يتم جمع عينة دم بسيطة في المنزل عبر خدمة الفصد المتنقل، ثم يستخرج الحمض النووي ويُسلسل بتقنية NGS مع تأكيد الطفرات بواسطة سانجر. مدة النتيجة 3 إلى 4 أسابيع.
3. Is this LHCGR gene covered by insurance in the UAE?
Direct billing verification via WhatsApp (+971 54 548 8731) confirms coverage with leading UAE insurers including Daman, NAS, Neuron, and MedGulf based on policy terms and clinical necessity. We handle all pre-authorization paperwork and insurance correspondence.
نوفر خدمة التحقق المباشر من التأمين عبر واتساب (+971 54 548 8731). تشمل التغطية شركات ضمان وناس ونيورون وميدغلف وفقاً لسياسة التأمين والضرورة الطبية.
This service complies with Federal Decree-Law No. 41 of 2024, Article 87 (Medical Liability), UAE CDS Law 2026 (Minors’ Consent for Genetic Testing), and UAE Personal Data Protection Law (PDPL). Facility License 9834453. ISO 9001:2015 Certified (INT/EGQ/2509DA/3139).
دعم ثنائي اللغة متاح
التحقق من التغطية التأمينية
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Stop the guesswork. Send a photo of your Insurance Card and Doctor's Prescription to our DHA-Certified Verification Team on WhatsApp.
توقف عن التخمين. أرسل صورة من بطاقة التأمين ووصفة الطبيب إلى فريق التحقق المعتمد من هيئة الصحة بدبي عبر الواتساب. احصل على تحديث الحالة في دقائق.
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All reports reviewed by DHA-Certified physicians