Test Price
2,800 AEDโ Home Collection Available
SYCP3 Gene Sequencing (SPGF4) โ NGS Test in UAE | 2,800 AED | DHA Licensed
Executive Summary & Core Metrics
The SYCP3 Gene Sequencing (SPGF4) NGS Test delivers targeted analysis of the SYCP3 gene to identify pathogenic variants causing spermatogenic failure type 4, a primary genetic contributor to non-obstructive azoospermia in males. Performed at DNA Labs UAE (DHA Licensed Facility 1143), this test achieves 99.9% diagnostic accuracy through ISO 9001:2015 certified next-generation sequencing workflows. Results are delivered within 21โ28 calendar days with a comprehensive clinical report including variant interpretation, ACMG classification, and tailored genetic counseling recommendations. VIP Mobile Phlebotomy & Temperature-Controlled Cold-Chain Home Collection is available across all UAE emirates daily from 8 AM to 11 PM. Post-test teleconsultation with our Consultant Medical Genetics is included for result discussion and family planning guidance.
Test Overview & Methodology
The SYCP3 gene encodes a component of the synaptonemal complex essential for homologous chromosome pairing during meiosis. Pathogenic variants in SYCP3 disrupt meiotic recombination, leading to spermatogenic arrest and non-obstructive azoospermia. This targeted NGS assay provides full coverage of all coding exons, splice sites, and flanking intronic regions of SYCP3 at a minimum depth of 100ร, ensuring high sensitivity for clinically relevant variants.
| Feature | SYCP3 NGS Test (Ours) | Whole Exome Sequencing |
|---|---|---|
| Target | SYCP3 gene only (high depth 100ร) | All exons (lower depth per gene) |
| Diagnostic Yield | Optimized for SPGF4 detection with deep intronic coverage | Broad but may miss deep intronic variants in SYCP3 |
| Turnaround Time | 21โ28 days | 4โ6 weeks |
| Cost | 2,800 AED | ~5,000 AED |
| Reporting | Clinically accredited report with ACMG variant classification | Variant list; may require secondary analysis |
Physician Insight & Safety Protocols
โMale infertility evaluation requires a systematic approach beginning with semen analysis and hormonal profiling. The SYCP3 gene test provides a targeted molecular diagnosis for men with non-obstructive azoospermia of suspected genetic origin. A definitive variant finding can directly influence reproductive options, including the feasibility of testicular sperm extraction (TESE) and preimplantation genetic testing. I always recommend pre-test genetic counseling to ensure patients fully understand the implications of germline findings for themselves and their family members.โ โ Lina Osama Zaki Quteineh, Consultant Medical Genetics, DHA Registration ID: 9294403
Pre-Test Advisory & Preparation
- No fasting is required for this genetic blood test.
- Inform your referring physician about any anticoagulant medications prior to collection.
- A signed informed consent form is mandatory before sample collection as per Federal Decree-Law No. 4 of 2016 on Medical Liability.
- Results are typically available within 21โ28 days; post-test genetic counseling is included in the service.
Exclusion Criteria & Clinical Contraindications
- Active systemic infection or febrile illness โ defer blood collection until resolved.
- Known bleeding disorder or concurrent anticoagulant therapy โ inform phlebotomist prior to draw for risk assessment.
- Inability to provide informed consent; for minors, a legal guardian must provide consent in accordance with UAE Federal Law No. 2 of 2019.
- Sample integrity requires cold-chain transport at +2ยฐC to +8ยฐC; delays exceeding 24 hours may compromise results.
- Emergency attention required if severe dizziness, syncope, or persistent bleeding occurs after venipuncture.
Patient FAQ & Clinical Guidance
1. What is the SYCP3 gene test used for?
The SYCP3 NGS test identifies pathogenic variants in the SYCP3 gene that cause spermatogenic failure type 4 (SPGF4), a genetic condition leading to non-obstructive azoospermia in males. This targeted analysis helps determine the underlying cause of male infertility and guides reproductive planning, including the suitability of assisted reproductive technologies such as intracytoplasmic sperm injection (ICSI) with surgically retrieved sperm.
2. How long does it take to receive results?
Results are delivered within 21 to 28 calendar days from sample receipt at the laboratory. The turnaround time accounts for DNA extraction, library preparation, high-depth NGS sequencing, bioinformatics analysis, variant interpretation according to ACMG guidelines, and clinical report generation. You will receive a secure digital copy of the report and a follow-up teleconsultation with a genetics specialist.
3. Is home blood collection available for this test?
Yes, VIP Mobile Phlebotomy & Temperature-Controlled Cold-Chain Home Collection is available daily from 8 AM to 11 PM across all seven UAE emirates. A trained phlebotomist will collect a peripheral whole blood sample at your residence or workplace under strict sterile conditions. The sample is transported under continuous cold-chain monitoring to preserve nucleic acid integrity for sequencing.
4. Will my insurance cover the cost of this test?
Coverage varies by insurance provider and policy. The test price is 2,800 AED for self-pay patients. To verify your insurance coverage and direct billing options, please contact our billing team via WhatsApp at +971 54 548 8731 with your policy details and referral letter.
5. What happens if a pathogenic variant is found?
If a pathogenic or likely pathogenic variant is identified in the SYCP3 gene, our Consultant Medical Genetics will discuss the findings with you during a complimentary post-test teleconsultation. The discussion will cover the inheritance pattern, implications for natural conception, reproductive options such as ICSI with TESE, and recommendations for genetic testing of family members if appropriate.
UAE Regulatory & Data Privacy Adherence
DNA Labs UAE operates under DHA Facility License Number 1143 and complies with all applicable UAE federal regulations governing clinical laboratory practice and patient data protection. All genetic data generated from the SYCP3 gene sequencing test is processed and stored in accordance with Federal Decree-Law No. 45 of 2021 on Personal Data Protection (PDPL) and Federal Law No. 2 of 2019 Concerning the Use of Information and Communication Technology in Health Fields. Patient consent, sample handling, and clinical reporting follow the standards established under Federal Decree-Law No. 4 of 2016 on Medical Liability. No genetic data is shared with third parties without explicit written patient consent. Secure encrypted digital reports are delivered via authenticated channels, and physical records are maintained in access-controlled facilities.
Clinical & Logistical Metadata
| Test Name | SYCP3 Gene Sequencing (SPGF4) โ NGS Test |
| Price (AED) | 2,800 AED |
| Turnaround Time | 21โ28 calendar days |
| Sample Type / Matrix | Peripheral whole blood (EDTA tube) |
| Methodology Used | Next-Generation Sequencing (NGS) โ targeted gene panel, minimum 100ร depth |
| ICD-10-CM Code | N46.0 (Azoospermia) |
| LOINC Code | 81247-9 (Master HL7 genetic variant reporting panel) |
| DHA Facility License & Laboratory Address | DHA License No. 1143 | Premises 105, Floor 1, Building 33, Dubai Healthcare City, Dubai, UAE |
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