Preimplantation Genetic Diagnosis (PGD) HLA Typing (Single Embryo) in UAE

Executive Summary & Core Metrics

Accuracy Guarantee: 99.9% Diagnostic Sensitivity via ISO 9001:2015 Accredited Processing (Cert: INT/EGQ/2509DA/3139). Our Sanger sequencing protocol ensures precise HLA allele matching for optimal transplant compatibility.
Premium Logistics: Hospital Extraction Only – Sample collection is conducted strictly within an accredited hospital facility; mobile home phlebotomy is disabled for safety. Embryo biopsy samples are transported in temperature-controlled, chain-of-custody systems compliant with UAE genetic data laws.
Clinical Guidance: Telephonic Post-Test Clinical Guidance in result interpretation by our specialist panel, ensuring your fertility specialist receives actionable, clinically correlated data.
Insurance: Direct Billing Verification via WhatsApp at +971 54 548 8731. We coordinate with major UAE insurers to streamline claims.

Test Overview & Methodology

Preimplantation Genetic Diagnosis (PGD) for Human Leukocyte Antigen (HLA) typing on a single embryo is a highly specialized genetic test that screens embryos created through IVF for specific HLA tissue types. This enables selection of embryos that are HLA-matched to an existing sibling suffering from a life-threatening haematological or inherited disorder, offering the possibility of curative stem cell transplantation after birth. This test combines Sanger sequencing precision with ISO 9001:2015 accredited laboratory workflows, delivering clinically actionable results within 3 weeks.

Feature	Our PGD HLA Typing (Sanger)	Closest Alternative (NGS Panel)
Precision & Resolution	99.9% allele-level accuracy via targeted Sanger sequencing	High-resolution NGS; may introduce bioinformatic ambiguities in heterozygous loci
Methodology	Gold-standard capillary electrophoresis with bidirectional confirmation	Massively parallel sequencing; less direct for single-gene/allele verification
Turnaround Time	3 weeks (including confirmation steps)	4–6 weeks (batch-dependent, higher cost)
Compliance	Fully aligned with Federal Decree-Law No. 45 of 2021 on Personal Data Protection (PDPL) and DHA genetic testing regulations	Often requires offshore processing; may fall outside UAE data sovereignty

Physician Insight & Safety Protocols

“As a Consultant Medical Geneticist, I emphasize that PGD HLA typing is a profound step intertwining advanced reproductive medicine with curative intent for an existing child. Our team ensures every result is interpreted within the context of your family's unique genetic landscape. However, a positive HLA match does not guarantee transplant success; clinical correlation and a multidisciplinary council remain essential. We walk this delicate path with empathy, precision, and unwavering commitment to ethical standards.”

— Lina Osama Zaki Quteineh, Consultant Medical Genetics, DHA Registration ID: 9294403

Medication Advisory

Do not discontinue any prescribed medication before or after the test without consulting your treating physician. Abrupt changes can jeopardize the IVF cycle or underlying health conditions.

Exclusion Criteria & Emergency Red Flags

Active vaginal bleeding or suspected ectopic pregnancy prior to embryo biopsy.
Known anticoagulant therapy that cannot be temporarily managed—please discuss with your IVF specialist.
Severe ovarian hyperstimulation syndrome (OHSS) symptoms: rapid weight gain, severe abdominal pain, shortness of breath—seek immediate emergency care.
Fever (>38°C) or signs of pelvic infection around the time of biopsy.
No viable embryo available for biopsy; test cannot proceed.

Patient FAQ & Clinical Guidance

1. What is PGD HLA typing and why is it performed on a single embryo?

Preimplantation genetic diagnosis for HLA aims to select an embryo that is tissue-type matched to a sibling who requires a haematopoietic stem cell transplant. This technique, employed by UAE fertility centers in compliance with Federal Decree-Law No. 45 of 2021 on Personal Data Protection (PDPL) and DHA regulations, ensures that the future child can serve as a compatible donor without risk of graft rejection, offering a curative path for diseases like beta-thalassaemia or leukaemia.

2. How accurate is this test and how long until I receive the results?

Our ISO 9001:2015 certified Sanger sequencing platform achieves 99.9% diagnostic sensitivity for HLA allele assignment, with results delivered to your fertility specialist within 3 weeks—significantly faster than many NGS alternatives. Every run includes internal controls and bidirectional reads to eliminate false positives, and the clinic receives a detailed, DHA-compliant report ready for clinical decision-making.

3. Do I need a doctor’s prescription and what are the requirements for the test?

A valid doctor’s prescription is mandatory for processing; this is not available for self-request due to its clinical implications. Note that a prescription is not applicable for surgical cases, ongoing pregnancies, or individuals planning to travel abroad without a documented medical need. Additionally, written informed consent compliant with Federal Decree-Law No. 4 of 2016 on Medical Liability is required, as genetic information pertains to the potential child. You can begin the process by contacting our team via WhatsApp to verify insurance coverage and schedule the embryo biopsy transport.

UAE Regulatory & Data Privacy Adherence

DNA Labs UAE strictly adheres to Federal Decree-Law No. 45 of 2021 on Personal Data Protection (PDPL) and Federal Law No. 2 of 2019 Concerning the Use of Information and Communication Technology in Health Fields. All genetic data from PGD HLA typing is encrypted, stored within UAE sovereign boundaries, and accessed only by authorized clinical personnel. Our laboratory holds ISO 9001:2015 certification (Cert: INT/EGQ/2509DA/3139) and complies with DHA standards for diagnostic genetic testing, ensuring your sensitive medical information remains confidential and secure.

Clinical & Logistical Metadata

Test Name	Preimplantation Genetic Diagnosis (PGD) HLA Typing (Single Embryo)
Price (AED)	4,000
Turnaround Time	3 weeks (21 days)
Sample Type / Matrix	Embryo Biopsy (Hospital Extraction Only)
Methodology Used	Sanger Sequencing (Capillary Electrophoresis)
ICD-10-CM Code	Z31.82 (Encounter for preimplantation genetic diagnosis)
LOINC Code	96545-9 (HLA typing by molecular genetics)
DHA Facility License & Laboratory Address	License No. 1143 \| Premises 105, Floor 1, Building 33, Dubai Healthcare City, Dubai, UAE