Test Price
800 AED✅ Home Collection Available
Thiopurine Methyltransferase (TPMT – *2, *3A, *3B, *3C) Genotyping in UAE | 800 AED | DHA Licensed Lab
Executive Summary & Core Metrics
- ✔ Accuracy Guarantee: 99.99% Diagnostic Sensitivity via ISO 9001:2015 Accredited Sanger Sequencing.
- ✔ Premium Logistics: VIP Mobile Phlebotomy & Temperature-Controlled Cold-Chain Home Collection available daily from 8 AM to 11 PM.
- ✔ Clinical Guidance: Telephonic Post-Test Clinical Guidance for precise result interpretation.
- ✔ Insurance: Direct Billing Verification via WhatsApp +971 54 548 8731.
- ✔ Turnaround Time: 5–7 business days.
- ✔ Price: 800 AED (inclusive of VAT).
Test Overview & Methodology
This pharmacogenetic panel identifies common TPMT variant alleles (*2, *3A, *3B, *3C) to predict thiopurine drug metabolism capacity and the risk of severe myelosuppression. It guides personalised dosing for azathioprine, 6-mercaptopurine, and thioguanine, preventing life-threatening toxicity.
Our laboratory utilises Sanger Sequencing as the gold-standard methodology, ensuring comprehensive detection of all clinically relevant TPMT variants with 99.99% accuracy.
| Feature | Our ISO-Certified TPMT Genotyping | Standard/Alternative Genotyping |
|---|---|---|
| Methodology | Sanger Sequencing (Gold-Standard for variant coverage) | Often targeted PCR, may miss rare or novel variants |
| Turnaround Time | 5–7 Days | 7–14 Days (variable) |
| Regulatory & Quality | DHA/MOHAP Compliant; ISO 9001:2015 (Cert: INT/EGQ/2509DA/3139) | May lack local DHA accreditation |
| Post-Test Support | Telephonic clinical guidance & physician consultation | Usually absent |
Physician Insight & Safety Protocols
Lina Osama Zaki Quteineh – Consultant Medical Genetics (DHA Registration: 9294403)
“TPMT genotyping is the essential first step before initiating thiopurine therapy – it unveils genetic susceptibility to severe bone marrow toxicity. I always interpret the results in the context of complete blood counts and liver function tests, never in isolation. Patient safety demands this molecular insight alongside vigilant clinical monitoring.”
Medication Warning & Emergency Red Flags
⚠ Do not discontinue or modify any prescribed medication without direct consultation with your licensed physician. This test guides therapy but does not replace clinical judgment.
- Seek immediate medical attention if after starting thiopurine drugs you experience unexplained bleeding, easy bruising, severe fatigue, pallor, shortness of breath, fever > 38.5°C, or jaundice.
Exclusion Criteria for Testing
- Recent blood transfusion (< 4 weeks)
- Active severe anemia (Hb < 8 g/dL)
- Acute pregnancy-related complications or unstable clinical state
- Non-consenting individual (mandatory DHA informed consent)
Patient FAQ & Clinical Guidance
1. What does TPMT genotyping diagnose or predict?
TPMT genotyping identifies genetic variants that impair metabolism of thiopurine drugs, predicting high risk of severe bone marrow toxicity and guiding dose reduction.
2. How do I prepare for the TPMT genotyping test in UAE?
No fasting or special preparation is required; simply provide your valid Emirates ID and prescription, and our hygienic home collection team arrives within 60 minutes.
3. Why choose this laboratory over standard TPMT testing?
Our laboratory delivers ISO-certified Sanger sequencing with 99.99% sensitivity, DHA-licensed post-test clinical guidance, and direct insurance verification, ensuring unmatched accuracy and patient safety.
UAE Regulatory & Data Privacy Adherence
Your personal and medical data are protected under Federal Decree-Law No. 45 of 2021 on Personal Data Protection (PDPL) and Federal Law No. 2 of 2019 Concerning the Use of Information and Communication Technology in Health Fields. All clinical procedures adhere to Federal Decree-Law No. 4 of 2016 on Medical Liability for patient safety and consent. DNA Labs UAE operates under DHA Facility License 1143 and complies with all UAE healthcare regulatory standards.
Clinical & Logistical Metadata
| Test Name | Thiopurine Methyltransferase (TPMT – *2, *3A, *3B, *3C) Genotyping |
| Price (AED) | 800 |
| Turnaround Time | 5–7 business days |
| Sample Type / Matrix | Peripheral whole blood (EDTA or citrate) |
| Methodology Used | Sanger Sequencing |
| ICD-10-CM Code | Z13.5 (Encounter for screening for other genetic and chromosomal anomalies) |
| LOINC Code | 90330-2 (TPMT gene mutation analysis in blood) |
| DHA Facility License & Laboratory Address | License No: 1143 | Premises 105, Floor 1, Building 33, Dubai Healthcare City, Dubai, UAE – DNA Labs UAE |
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All reports reviewed by DHA-Certified physicians