Test Price
1,000 AED✅ Home Collection Available
Irinotecan Toxicity Assessment (UGT1A1 Genotyping)/Gilbert Syndrome in UAE | 1000 AED | 2026 DHA Guidelines
تحليل تقييم سمية الإرينوتيكان (فحص جين UGT1A1) / متلازمة جيلبرت في الإمارات | 1000 درهم | معتمد من هيئة الصحة بدبي
✓ Diagnostic Accuracy: 99.9% Sensitivity via ISO 9001:2015 Accredited Sequencing
✓ Premium Logistics: ISO‑Certified Cold‑Chain Home Collection (VIP Mobile Phlebotomy 8 AM–11 PM)
✓ Clinical Guidance: Post‑Test Telephonic Clinical Correlation & Interpretation by DHA‑Licensed Experts
✓ Direct Insurance Billing Verification via WhatsApp: +971 54 548 8731
Overview
The Irinotecan Toxicity Assessment (UGT1A1 Genotyping) precisely detects variants in the UGT1A1 gene that predict severe adverse reactions to irinotecan chemotherapy and diagnose Gilbert syndrome. In the UAE, this pharmacogenetic test empowers oncologists, gynecologic‑oncologists, and preventive medicine specialists to personalize dosage and avoid life‑threatening myelosuppression.
يكشف هذا الفحص الجيني عن طفرات جين UGT1A1 المسؤولة عن سمية الإرينوتيكان ومتلازمة جيلبرت، مما يدعم التخصيص الدوائي الآمن في الإمارات.
| Feature | Our Test (UGT1A1 Sequencing) | Typical Alternative (PCR Panel) |
|---|---|---|
| Methodology | Sanger Sequencing (Gold Standard) | Allele‑specific PCR (limited common variants) |
| Precision | 100% Specificity, detects rare & novel variants | Misses rare variants; lower sensitivity |
| TAT | 7–8 Days (Express possible) | 10–14 Days |
| Price | 1000 AED | Variable; often not all‑inclusive |
*TAT: Turnaround Time from sample receipt at our DHA‑MOHAP licensed facility (License: 9834453). Price includes home collection, sequencing, and telephonic guidance.
Clinical Correlation & Safety
“As a DHA‑licensed physician, I emphasise that UGT1A1 genotyping must always be interpreted in the full clinical context. While a *28/*28 genotype strongly predicts irinotecan toxicity, it is not an absolute contraindication; dose adjustment under oncologist supervision is mandatory. Any yellowing of the eyes or recurrent jaundice warrants this test, but never ignore sudden abdominal pain or fever—seek emergency care.”
— Dr. PRABHAKAR REDDY, DHA License 61713011
⚠ Medication Warning
Do not discontinue, alter, or self-adjust any prescribed medication, especially irinotecan or other chemotherapy agents, without direct consultation with your treating physician. This test informs clinical decisions but does not replace oncological judgment.
Exclusion Criteria & Urgent Red Flags
- This test is not indicated for acute abdominal emergency triage, routine pregnancy screening, or travel visa medical certificates.
- Not suitable for individuals who have received an allogeneic bone marrow transplant within the last 3 months (donor DNA interference).
- If you experience sudden severe abdominal pain, high fever (>38.5°C), confusion, or bleeding, proceed directly to the nearest emergency department—do not wait for test results.
- Known diagnosis of Crigler‑Najjar syndrome type 1 should be evaluated via a different urgent pathway.
Pre‑Test Requirements
A valid physician prescription is mandatory for all clinical indications. This test is not appropriate for pre‑surgical clearance, pregnancy‑related screening, or travel health certificates. Sample type: Peripheral Blood (EDTA tube). Fasting is not required.
Frequently Asked Questions
Q: Is this test necessary before starting irinotecan chemotherapy?
Yes, UGT1A1 genotyping is essential to identify patients at risk of severe neutropenia and diarrhea from irinotecan. The U.S. FDA and ESMO guidelines recommend testing for UGT1A1*28 allele prior to irinotecan administration. Poor metabolizers require a significant dose reduction to avoid life‑threatening toxicity. Our comprehensive sequencing covers all clinically relevant promoter and coding variants, ensuring no risk is missed.
س: هل هذا الفحص ضروري قبل بدء العلاج الكيميائي بالإرينوتيكان؟
نعم، فحص جين UGT1A1 ضروري لتحديد المرضى المعرضين لخطر قلة العدلات الشديدة والإسهال. توصي هيئات الدواء الأمريكية والأوروبية بفحص الطفرة *28، ويعاني ضعيفو الاستقلاب من سمية خطيرة تستوجب تخفيض الجرعة.
Q: Can this test confirm if I have Gilbert syndrome?
Yes, homozygosity for UGT1A1*28 (TA7/TA7) confirms Gilbert syndrome with >99% accuracy, distinguishing benign hyperbilirubinemia from liver disease. Gilbert syndrome is a harmless condition causing intermittent mild jaundice, but genetic confirmation prevents unnecessary invasive procedures. Our also identifies compound heterozygous mutations for atypical presentations, providing peace of mind.
س: هل يمكن لهذا الفحص تأكيد إصابتي بمتلازمة جيلبرت؟
نعم، تماثل الزيجوت لطفرة UGT1A1*28 يؤكد متلازمة جيلبرت بدقة تزيد عن 99%. تمنع هذه النتيجة إجراءات طبية غير ضرورية وتوضح سبب اليرقان المتقطع الحميد.
Q: How is the sample collected, and when will I receive my results?
Our certified phlebotomists collect a peripheral blood sample at your home within 8 AM–11 PM, and results are delivered in 7–8 days. Using ISO‑certified cold‑chain transport, the specimen reaches our DHA‑licensed lab in optimal condition. You’ll receive a detailed report with genotype interpretation, clinical recommendations, and a scheduled telephone consultation with a molecular pathologist.
س: كيف يتم جمع العينة ومتى أحصل على النتائج؟
يجمع اختصاصيو سحب الدم لدينا عينة من الدم المحيطي في منزلك بين 8 صباحاً و11 مساءً، وتظهر النتائج خلال 7–8 أيام. تُنقل العينة بسلسلة تبريد معتمدة، وتتضمن النتيجة استشارة هاتفية مع مختص.
ISO 9001:2015 Certified (Cert: INT/EGQ/2509DA/3139). Licensed by DHA/MOHAP – Facility 9834453.
Operated in full compliance with UAE Federal Decree‑Law No. 41 of 2024 (Art. 87), Child Data Safeguards (CDS Law 2026 for minors), and UAE PDPL.
All telephonic guidance is provided by DHA‑licensed clinicians. WhatsApp Support: +971 54 548 8731.
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توقف عن التخمين. أرسل صورة من بطاقة التأمين ووصفة الطبيب إلى فريق التحقق المعتمد من هيئة الصحة بدبي عبر الواتساب. احصل على تحديث الحالة في دقائق.
Available in Arabic, English, Hindi & Urdu
ISMS 27001:2022
ISO Accredited
HIPAA
All reports reviewed by DHA-Certified physicians