Test Price
2,800 AED✅ Home Collection Available
SERPINH1 Gene Osteogenesis Imperfecta Type 10 Genetic Test in UAE | 2800 AED
Executive Summary & Core Metrics
DHA-Approved Genetic Profiling – Unmatched Accuracy & UAE Compliance
- Accuracy Guarantee: 99.9% Diagnostic Sensitivity via ISO 9001:2015 Accredited NGS & Sanger Validation.
- Premium Logistics: VIP Mobile Phlebotomy & Temperature-Controlled Cold-Chain Home Collection (Available daily from 8 AM to 11 PM).
- Clinical Guidance: Telephonic Post-Test Clinical Guidance by DHA-Licensed Genetic Counsellor for result interpretation.
- Insurance: Direct Billing Verification via WhatsApp at +971 54 548 8731.
Test Overview & Methodology
SERPINH1 gene sequencing is the definitive molecular diagnostic tool for Osteogenesis Imperfecta Type 10, a severe autosomal recessive collagenopathy. This next‑generation sequencing (NGS) test analyzes the entire coding region of SERPINH1 (HSP47) for pathogenic variants, enabling accurate diagnosis, carrier screening, and personalized management planning under DHA-approved genetic testing protocols.
| Feature | Our SERPINH1 NGS Test | Closest Alternative (Sanger Sequencing Only) |
|---|---|---|
| Precision | Full gene coverage + copy number variant detection (99.9% sensitivity) | Targeted amplicons only; may miss deep intronic or regulatory variants |
| Method | NGS (Illumina NovaSeq) with Sanger confirmation of pathogenic calls | Sanger sequencing of selected exons |
| Turnaround Time | 3–4 Weeks (Standard) | 4–6 Weeks |
Physician Insight & Safety Protocols
“As a Consultant Medical Genetics, I emphasize that a SERPINH1 genetic result must be interpreted within the full clinical and radiological context. A positive finding confirms the molecular diagnosis but does not replace thorough patient assessment and family counseling. Please always correlate with your specialist before making any treatment changes.”
— Lina Osama Zaki Quteineh, Consultant Medical Genetics, DHA Registration ID: 9294403
Patient Safety Advisory
Important Warning
Do not discontinue prescribed medication or modify bone management plans without consulting your doctor. This test is for diagnostic and surveillance purposes only.
Exclusion Criteria & Red Flags
- Exclusion: Active infection or acute fracture at the time of blood draw (defer until stabilized).
- Exclusion: Inability to provide informed consent (legal guardian must sign for minors per Federal Decree-Law No. 4 of 2016 on Medical Liability).
- Red Flag: Sudden severe bone pain, new deformities, or loss of mobility – seek emergency orthopaedic evaluation immediately.
- Red Flag: Respiratory distress or chest wall abnormalities – possible OI-related pulmonary compromise, call 998.
Patient FAQ & Clinical Guidance
1. What does a positive SERPINH1 gene test mean for my child’s bone health?
A positive result confirms Osteogenesis Imperfecta Type 10, a genetic collagen disorder characterized by bone fragility, recurrent fractures, and often blue sclerae. It means your child carries two mutated copies of SERPINH1, requiring immediate multidisciplinary care from a pediatric orthopaedist and clinical geneticist to optimize bone strength and prevent fractures. Always discuss findings with your DHA-licensed physician.
2. How is the sample collected and how long do results take?
A small blood sample is collected via VIP Mobile Phlebotomy at your home or at our facility, with results available in 3 to 4 weeks. The sample is processed via NGS with Sanger validation for any detected variant, ensuring the highest clinical accuracy mandated by ISO 9001:2015.
3. Is this covered by UAE health insurance?
Many UAE insurers cover medically indicated genetic tests when accompanied by a specialist referral and pre-authorization. We provide direct billing verification through WhatsApp at +971 54 548 8731; our team will confirm coverage within one business day, and you can use our insurance facilitation to reduce out‑of‑pocket costs.
UAE Regulatory & Data Privacy Adherence
Compliance Framework
This test is conducted in full compliance with Federal Decree-Law No. 45 of 2021 on Personal Data Protection (PDPL) and Federal Law No. 2 of 2019 Concerning the Use of Information and Communication Technology in Health Fields. All patient data is securely encrypted, and results are shared only with the referring physician and patient as per consent. Clinical safety and patient consent adhere to Federal Decree-Law No. 4 of 2016 on Medical Liability.
Clinical & Logistical Metadata
| Test Name | SERPINH1 Gene Osteogenesis Imperfecta Type 10 Genetic Test |
| Price (AED) | 2800 |
| Turnaround Time | 3–4 Weeks (Standard) |
| Sample Type / Matrix | Peripheral Whole Blood (3-5 mL in EDTA tube) or Buccal Swab |
| Methodology Used | Next-Generation Sequencing (NGS) on Illumina NovaSeq with Sanger Confirmation |
| ICD-10-CM Code | Q78.0 |
| LOINC Code | 82899-3 |
| DHA Facility License & Laboratory Address | DHA Facility License No: 1143 | Premises 105, Floor 1, Building 33, Dubai Healthcare City, Dubai, UAE – DNA Labs UAE |
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ISMS 27001:2022
ISO Accredited
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