Test Price
2,800 AED✅ Home Collection Available
CRTAP Gene Osteogenesis Imperfecta Type VII Genetic Test in UAE | 2800 AED | 2026 DHA Guidelines
تحليل جين CRTAP لتكون العظم الناقص النوع السابع في الإمارات | 2800 درهم | معتمد من هيئة الصحة بدبي
Executive Summary & Patient Promise
- Accuracy Guarantee: 99.9% Diagnostic Sensitivity via ISO Certified Processing
- Premium Logistics: Paid Hospital-Grade Home Collection via ISO Certified Cold-Chain Home Collection & VIP Mobile Phlebotomy
- Clinical Guidance: Telephonic Post-Test Clinical Guidance in result interpretation
- Insurance: Direct Billing Verification via WhatsApp +971 54 548 8731
ملخص تنفيذي
- ضمان الدقة: حساسية تشخيصية بنسبة 99.9% عبر معالجة معتمدة من الأيزو
- الخدمات اللوجستية المميزة: سحب منزلي بمواصفات المستشفيات عبر سلسلة تبريد معتمدة وخدمة فصد متنقلة VIP
- الإرشاد السريري: استشارة هاتفية بعد الفحص لتفسير النتائج
- التأمين: التحقق المباشر من الفواتير عبر واتساب +971 54 548 8731
Test Overview
The CRTAP Gene Osteogenesis Imperfecta Type VII Genetic Test analyzes the entire coding region of the CRTAP gene for pathogenic mutations, providing definitive genetic confirmation of the severe, autosomal recessive bone fragility disorder. This advanced next-generation sequencing test, performed on blood or DNA samples, delivers precise diagnostic information indispensable for clinical management, genetic counseling, and informed family planning.
باختصار، هذا الفحص الجيني المتقدم يؤكد تشخيص تكون العظم الناقص النوع السابع الناتج عن طفرات جين CRTAP، ويساعد في توجيه الرعاية الطبية والاستشارة الوراثية.
Our Test vs. Closest Alternative
| Feature | CRTAP NGS (This Test) | Whole Exome Sequencing |
|---|---|---|
| Precision | 100% coverage of CRTAP exons & splicing sites | Individual gene coverage ~85%; risk of missed variants |
| Methodology | Targeted NGS + MLPA for deletions | Broad NGS with incidental findings burden |
| Turnaround Time | 3–4 Weeks | 6–10 Weeks |
| Cost (UAE) | 2800 AED | 5000–7000 AED |
Physician Insight & Safety Protocol
“As a clinician, I understand the emotional weight of a possible osteogenesis imperfecta diagnosis. This test provides clarity, but results must always be interpreted in the context of a thorough clinical evaluation and family history. A positive report enables proactive management, while a negative result brings immense relief; either way, we are here to guide you through every step.”
— Dr. Prabhakar Reddy, DHA License: 61713011
Important Medication Warning: Do not discontinue any prescribed medication without consulting your doctor. This test does not replace ongoing fracture care or calcium/vitamin D supplementation unless specifically advised by your physician.
Safety & Exclusion Criteria
- Exclusion: Minors without verified parental/guardian consent as per UAE CDS Law 2026.
- Exclusion: Inability to provide venous blood, extracted DNA, or a dried blood spot on FTA card; alternative collection methods can be discussed.
- Exclusion: Active systemic infection at the time of sample collection (postpone until resolved).
- Emergency Red Flags: Seek immediate hospital care if the patient experiences sudden severe bone pain, inability to move a limb, breathing difficulties, or signs of spinal cord compression before or after sample collection.
Patient FAQ & Clinical Guidance
1. What is the CRTAP gene and how does it relate to Osteogenesis Imperfecta Type VII?
CRTAP gene mutations cause Osteogenesis Imperfecta Type VII, a severe, autosomal recessive bone fragility disorder confirmed by this Genetic Test. The CRTAP gene encodes cartilage-associated protein, a critical partner of collagen modification. When both copies carry a pathogenic variant, collagen is abnormally formed, leading to frequent fractures, progressive bone deformities, and often life-limiting complications. This test detects these mutations with high precision.
جين CRTAP ينتج بروتيناً ضرورياً لتعديل الكولاجين، والطفرة فيه تسبب النوع السابع من تكون العظم الناقص، وهو مرض وراثي متنحي شديد يتسم بكسور متكررة وتشوهات هيكلية، ويؤكد الفحص الجيني التشخيص بدقة.
2. How is the CRTAP gene test performed and what is the turnaround time?
The test uses next-generation sequencing of the entire CRTAP gene from a blood or DNA sample, with results in 3 to 4 weeks. A single blood draw (or buccal swab/FTA card) is collected at home or in a clinic. DNA is extracted and analyzed using high-coverage NGS, supplemented by copy number analysis to catch large deletions. The final report includes variant classification per ACMG guidelines and a clinical interpretation.
يتم الفحص عبر سحب عينة دم أو حمض نووي، تُحلل بتقنية التسلسل الجيني الشامل (NGS)، وتظهر النتائج خلال 3 إلى 4 أسابيع مع تفسير سريري مفصل.
3. What do positive CRTAP test results mean for patients and families?
A positive CRTAP result confirms Osteogenesis Imperfecta Type VII, guiding management and enabling genetic counseling for family planning. It indicates that the patient has two mutated copies of the gene, explaining existing symptoms and predicting recurrence risk (25%) in future pregnancies. Management includes a multidisciplinary team approach—orthopedic care, physiotherapy, bisphosphonate therapy—and cascade testing of at-risk relatives is recommended.
النتيجة الإيجابية تؤكد تشخيص النوع السابع من تكون العظم الناقص، وتوجه العلاج عبر فريق متعدد التخصصات، كما تتيح استشارة وراثية للعائلة حول احتمالية تكرار المرض في الأحمال القادمة.
UAE Regulatory Compliance: This service adheres to Federal Decree-Law No. 41 of 2024 (Art. 87) on human genetic testing, the UAE Child Data Safety (CDS) Law 2026 for minors, and the UAE Personal Data Protection Law (PDPL). Facility License: 9834453. ISO 9001:2015 Certification: INT/EGQ/2509DA/3139. Method: Next-Generation Sequencing (NGS). ICD-10-CM: Q78.0, Z15.89, Z82.79. LOINC: 93043-6. Pre‑ requirement: Clinical history and a genetic counselling session to construct a pedigree of family members affected by CRTAP‑related conditions. For queries or home collection, WhatsApp +971 54 548 8731 (8 AM‑11 PM).
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