Test Price
2,800 AED✅ Home Collection Available
PPIB Gene (Osteogenesis Imperfecta Type 9) Genetic Test in UAE | 2800 AED | DHA Licensed
Executive Summary & Core Metrics
This executive-grade DNA test delivers clinical certainty for families and physicians navigating brittle bone disorders. It screens the entire PPIB gene via next-generation sequencing with >99.9% diagnostic sensitivity.
Test Overview & Methodology
This NGS assay screens the entire coding region of the PPIB gene for single-nucleotide variants, small indels, and copy‑number changes, offering a definitive molecular diagnosis within 3–4 weeks. The method uses Illumina platform technology and covers coding exons ±20 bp intronic boundaries.
| Feature | Our Test | Closest Alternative |
|---|---|---|
| Method | Full gene NGS (Illumina platform) | Single‑gene Sanger sequencing |
| Coverage | Coding exons ±20 bp intronic boundaries | Selected exons only |
| Turnaround | 3–4 weeks | 6–8 weeks |
| Sensitivity | >99% for SNVs/indels | ~95% (misses deep intronic variants) |
Physician Insight & Safety Protocols
“As a DHA-licensed Consultant Medical Geneticist, I emphasize that this test must be interpreted within the full clinical picture. Genetic results alone do not define treatment; they inform a multidisciplinary plan. Patients and families are encouraged to review findings with a clinical geneticist or orthopaedic consultant to avoid unnecessary anxiety.” — Lina Osama Zaki Quteineh, Consultant Medical Genetics (DHA Registration ID: 9294403)
Medication Warning
Do not discontinue prescribed medication without consulting your doctor. Changing bisphosphonates or calcium/vitamin D supplements without medical supervision can worsen bone fragility.
Exclusion Criteria & Emergency Red Flags
- Active febrile illness or acute fracture within 2 weeks (may affect DNA integrity).
- Known complete gene deletion undetectable by standard NGS (requires MLPA).
- Patient unable to provide informed consent (mandatory genetic counselling).
- Seek emergency care if new-onset severe bone pain, sudden limb deformity, or neurological symptoms occur after blood draw.
Patient FAQ & Clinical Guidance
1. How accurate is the PPIB NGS test for osteogenesis imperfecta type 9?
This test provides greater than 99% analytical sensitivity and specificity for single nucleotide variants and small indels in the PPIB gene, making it a definitive first‑line diagnostic tool for type 9 OI.
2. What sample is required and can it be collected at home in Dubai?
A simple blood draw, dried blood spot on FTA card, or pre‑extracted DNA can be used. Our VIP mobile phlebotomy service covers all Emirates from 8 AM to 11 PM daily with temperature‑controlled cold‑chain logistics.
3. How long until I receive results, and will someone explain them?
Results are released within 3 to 4 weeks. A complementary telephonic consultation with a genetic counsellor is included to walk you through every finding.
4. Is the test covered by insurance?
Please contact our billing team via WhatsApp at +971 54 548 8731 for insurance pre‑approval and direct billing verification.
5. What happens if a variant of uncertain significance is found?
We report all findings according to ACMG/AMP guidelines. A genetic counsellor will discuss the clinical implications and recommend further family studies or additional testing if needed.
UAE Regulatory & Data Privacy Adherence
Compliance & Accreditation
- Licensed by DHA under Facility License No. 1143.
- Testing performed in compliance with Federal Decree-Law No. 45 of 2021 on Personal Data Protection (PDPL) and Federal Law No. 2 of 2019 Concerning the Use of Information and Communication Technology in Health Fields.
- Clinical safety and patient consent adhere to Federal Decree-Law No. 4 of 2016 on Medical Liability.
- ISO 9001:2015 Quality Management System — Certificate No. INT/EGQ/2509DA/3139. All assays follow CLIA‑equivalent NGS protocols.
Clinical & Logistical Metadata
| Test Name | PPIB Gene (Osteogenesis Imperfecta Type 9) Genetic Test |
| Price (AED) | 2,800 AED |
| Turnaround Time | 3–4 weeks |
| Sample Type / Matrix | Peripheral whole blood, dried blood spot (FTA card), or extracted genomic DNA. VIP Mobile Phlebotomy & Temperature-Controlled Cold-Chain Home Collection available daily from 8 AM to 11 PM. |
| Methodology Used | Next-Generation Sequencing (NGS) on Illumina platform; full gene coding exons ±20 bp intronic boundaries |
| ICD-10-CM Code | Q78.0 |
| LOINC Code | 92819-6 |
| DHA Facility License & Laboratory Address | DHA Facility License No. 1143 Premises 105, Floor 1, Building 33, Dubai Healthcare City, Dubai, UAE Corporate Lab Branding: DNA Labs UAE |
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