Test Price
2,800 AED✅ Home Collection Available
MPL Gene Exon 10 NGS Sequencing Test in UAE | 2800 AED
Executive Summary & Core Metrics
- Accuracy Guarantee: 99.9% Diagnostic Sensitivity via ISO 9001:2015 Accredited Processing (Cert: INT/EGQ/2509DA/3139).
- Premium Logistics: VIP Mobile Phlebotomy & Temperature-Controlled Cold-Chain Home Collection available daily from 8 AM to 11 PM.
- Clinical Guidance: Telephonic Post-Test Clinical Guidance in result interpretation by DHA-licensed genetics experts.
- Insurance: Direct Billing Verification via WhatsApp +971 54 548 8731.
Test Overview & Methodology
This targeted next-generation sequencing (NGS) test screens exon 10 of the MPL gene for somatic and germline mutations linked to essential thrombocythemia, primary myelofibrosis, and familial thrombocytosis. Ultra‑deep coverage enables detection of variants down to 1% VAF. Results are correlated with clinical features and haematological parameters to guide diagnosis and management of myeloproliferative neoplasms.
| Feature | Our Test: MPL Exon 10 NGS | Closest Alternative (Sanger Sequencing / Panel) |
|---|---|---|
| Precision | Ultra‑deep NGS – detects variants down to 1% VAF | Lower sensitivity; may miss low‑level mosaicism |
| Method | Full exon 10 capture + bioinformatics pipeline (ISO‑certified) | Partial coverage; often limited to hotspot codons |
| Turnaround | 3–4 weeks with dedicated case review | Variable; may require reflex testing, adding delays |
| Regulatory Compliance | Full DHA/MOHAP, UAE PDPL (Federal Decree‑Law No. 45 of 2021), Federal Law No. 2 of 2019 | Often lacks UAE‑specific genetic counselling mandate |
Physician Insight & Safety Protocols
“Every MPL mutation report is a piece of your health narrative. I read it not as a standalone verdict but within your full clinical picture – symptoms, blood counts, and family history. Please use this result to open a conversation, never to close one.”
— Lina Osama Zaki Quteineh, Consultant Medical Genetics, DHA Registration ID: 9294403
Medication Advisory
Please do not stop or alter any prescribed medication (e.g., hydroxyurea, anagrelide, aspirin) unless directed by your treating doctor. Abrupt discontinuation may increase thrombotic risk. Always consult your haematologist before making changes.
Exclusion Criteria & Emergency Red Flags
- Exclusion: Active severe bleeding or platelet count <50 × 10⁹/L requiring urgent haematological intervention; inability to provide informed consent per Federal Decree‑Law No. 4 of 2016 on Medical Liability.
- Post‑Test Red Flags: Sudden vision changes, severe headache, chest pain, or signs of thrombosis – seek emergency care immediately; these require clinical correlation irrespective of MPL status.
- Data Privacy: Genetic data handled under UAE PDPL (Federal Decree‑Law No. 45 of 2021); results disclosed only to ordering physician or authorized individual.
Patient FAQ & Clinical Guidance
1. What does the MPL Exon 10 NGS test detect, and why is it ordered?
This NGS assay precisely identifies somatic or germline mutations in exon 10 of the MPL gene, confirming essential thrombocythemia or primary myelofibrosis. It is ordered when a patient presents with unexplained high platelet counts, splenomegaly, or bone marrow features suggestive of a myeloproliferative neoplasm. The result stratifies risk and may guide use of JAK2/MPL‑targeted therapies, avoiding unnecessary invasive procedures.
2. How long does the result take, and do I need to fast or stop medications?
Results are delivered within 3 to 4 weeks; no fasting is required, but you must continue all prescribed medications unless your doctor advises otherwise. A blood sample or pre‑extracted DNA can be collected at our home service or clinic. Genetic counselling before testing is mandatory under UAE healthcare regulations and will be arranged by our team.
3. Is the MPL genetic test covered by insurance in the UAE?
Many UAE insurers cover MPL exon 10 sequencing when ordered by a haematologist or oncologist under a pre‑authorised genetic testing plan. Contact our support via WhatsApp at +971 54 548 8731 for direct billing verification and a detailed pre‑approval checklist. Our ISO‑certified laboratory coordination ensures compliance with current DHA coding standards.
UAE Regulatory & Data Privacy Adherence
ISO 9001:2015 Certified Laboratory
Cert: INT/EGQ/2509DA/3139 • DHA Facility License 1143
Corporate Lab Branding: DNA Labs UAE
Premises 105, Floor 1, Building 33, Dubai Healthcare City, Dubai, UAE
Compliant with Federal Decree‑Law No. 45 of 2021 on Personal Data Protection (PDPL) and Federal Law No. 2 of 2019 Concerning the Use of Information and Communication Technology in Health Fields.
Clinical & Logistical Metadata
| Test Name | MPL Gene Exon 10 NGS Sequencing |
| Price (AED) | 2,800 AED |
| Turnaround Time | 3–4 weeks |
| Sample Type / Matrix | Peripheral Whole Blood (EDTA) or Isolated DNA |
| Methodology Used | Next-Generation Sequencing (NGS) – targeted exon 10 capture with bioinformatics analysis |
| ICD-10-CM Code | D47.3 (Essential thrombocythemia), D47.1 (Chronic myeloproliferative disease) |
| LOINC Code | 93111-7 |
| DHA Facility License & Laboratory Address | DHA License No: 1143 | DNA Labs UAE, Premises 105, Floor 1, Building 33, Dubai Healthcare City, Dubai, UAE |
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