Test Price
2,800 AED✅ Home Collection Available
DOCK6 Gene Adams‑Oliver Syndrome Type 2 Genetic Test in UAE | 2800 AED | DHA Licensed
Executive Summary & Core Metrics
Comprehensive Molecular Diagnosis for AOS2
Achieve a definitive molecular diagnosis of Adams‑Oliver syndrome type 2 (AOS2) with our ISO‑certified, clinically validated genetic test. Full sequencing of the DOCK6 gene via next‑generation technology delivers 99.9% diagnostic sensitivity and 100% specificity for pathogenic variants, enabling accurate recurrence risk assessment and surgical planning guidance.
Test Overview & Methodology
The DOCK6 gene Adams‑Oliver syndrome type 2 Genetic Test interrogates the entire coding region and splice junctions of the DOCK6 gene for pathogenic and likely pathogenic variants associated with scalp cutis aplasia, terminal transverse limb defects, and other characteristic AOS2 manifestations. Utilising next‑generation sequencing (NGS) with 150 bp paired‑end reads at a mean depth exceeding 200×, the assay delivers an analytical sensitivity above 99.9% and a positive predictive value of 100% for confirmed variants. Results are classified per ACMG/AMP guidelines and reported with actionable clinical recommendations.
| Feature | Our Test (ISO 9001:2015 Certified) | Closest Alternative |
|---|---|---|
| Methodology | NGS full gene sequencing (coding + splice) | Targeted mutation panel or Sanger (limited hotspot variants) |
| Turnaround Time | 3–4 Weeks | 4–6 Weeks |
| Reporting | Clinically actionable report with ACMG classification & counselling referral | Basic variant list without interpretation |
Physician Insight & Safety Protocols
“Families confronting a possible diagnosis of Adams‑Oliver syndrome need clarity and speed. This DOCK6 NGS test provides a definitive molecular answer that refines recurrence risks for parents and helps surgeons plan corrective interventions for scalp aplasia and limb anomalies. Every result must be interpreted alongside a thorough physical examination and three‑generation family history.”
— Lina Osama Zaki Quteineh | Consultant Medical Genetics | DHA Registration ID: 9294403
Medication Safety Advisory
⚠ Do Not Alter Your Medications
Never discontinue or adjust any prescribed medication without consulting your treating physician. This genetic test is solely for diagnostic clarification and does not replace ongoing medical management or treatment plans. Continue all therapies as directed until your doctor advises otherwise.
Safety Exclusion Criteria & Emergency Red Flags
- Active anticoagulant therapy that cannot be safely paused for blood draw without haematology approval.
- Known or suspected inability to provide informed consent; mandatory genetic counselling per UAE Federal Law applies for minors and vulnerable individuals.
- Severe bleeding disorder or thrombocytopenia requiring hospital‑supervised phlebotomy only.
- ER Red Flags: If sudden severe headache, vision loss, or signs of infection (fever, chills, swelling) develop after sample collection, seek emergency medical attention immediately.
Patient FAQ & Clinical Guidance
1. What does the DOCK6 Adams‑Oliver syndrome type 2 test detect?
Direct Answer: The test sequences the entire DOCK6 gene to identify pathogenic mutations responsible for the characteristic scalp cutis aplasia and terminal transverse limb defects of Adams‑Oliver syndrome type 2. A positive result confirms the diagnosis, clarifies recurrence risk for family planning, and enables targeted surveillance for associated vascular anomalies.
2. How is the sample collected and what should I expect?
Direct Answer: A certified phlebotomist performs a standard venous blood draw during a scheduled home visit. Discomfort is minimal and comparable to routine blood work. No fasting or special preparation is required beyond providing your complete clinical history and any prior genetic test results. The sample is transported via temperature‑controlled cold chain to our ISO‑accredited laboratory.
3. When will I receive my results and how are they explained?
Direct Answer: Results are available within 3–4 weeks and released through a secure encrypted online portal. A board‑certified genetic counsellor then conducts a 15‑minute telephonic interpretation session to explain the clinical significance, discuss implications for family members, and coordinate any recommended follow‑up care with your referring physician.
UAE Regulatory & Data Privacy Adherence
DNA Labs UAE operates under the regulatory oversight of the Dubai Health Authority (DHA Facility License No. 1143). All genetic data generated by this test is processed and stored in full compliance with:
- Federal Decree-Law No. 45 of 2021 on Personal Data Protection (PDPL) – governing the collection, processing, and transfer of personal and genetic data.
- Federal Law No. 2 of 2019 Concerning the Use of Information and Communication Technology in Health Fields – ensuring secure digital health information exchange.
- Federal Decree-Law No. 4 of 2016 on Medical Liability – regulating clinical testing safety, informed consent, and patient rights.
Your genetic information remains confidential and is never shared with third parties without your explicit written consent.
Clinical & Logistical Metadata
| Test Name | DOCK6 Gene Adams‑Oliver Syndrome Type 2 Genetic Test |
| Price (AED) | 2,800 AED |
| Turnaround Time | 3–4 Weeks |
| Sample Type / Matrix | Peripheral whole blood (venous draw) or FTA card dried blood spot; VIP mobile phlebotomy & temperature‑controlled cold‑chain home collection available daily 8 AM–11 PM. |
| Methodology Used | Next‑Generation Sequencing (NGS) – full coding region & splice junctions, 150 bp paired‑end reads, mean depth >200× |
| ICD-10-CM Code | Q87.2 |
| LOINC Code | 90262-4 |
| DHA Facility License & Laboratory Address | DHA License No. 1143 | Premises 105, Floor 1, Building 33, Dubai Healthcare City, Dubai, UAE – DNA Labs UAE |
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