Test Price
2,800 AED✅ Home Collection Available
WWOX Gene NGS Test for Early Infantile Epileptic Encephalopathy Type 28 (EIEE28) in Dubai, UAE
Executive Summary & Core Metrics
The WWOX gene next‑generation sequencing (NGS) test identifies pathogenic variants causing early infantile epileptic encephalopathy type 28 (EIEE28), a severe neonatal‑onset neurogenetic disorder. This ISO‑accredited molecular analysis offers definitive confirmation with >99.9% analytical sensitivity and a 3–4‑week turnaround time. The test is available at 2800 AED and includes complimentary tele‑genetic counselling following results. VIP mobile phlebotomy and temperature‑controlled cold‑chain home collection are available daily from 8 AM to 11 PM.
Test Overview & Methodology
This targeted NGS assay sequences the entire coding region and exon‑intron boundaries of the WWOX gene. All pathogenic, likely pathogenic, and variants of uncertain significance are confirmed by Sanger sequencing. The test is performed using a validated high‑throughput platform with minimum 100x coverage depth across all target regions, ensuring robust detection of single‑nucleotide variants and small insertions/deletions.
| Features | Our WWOX NGS Test | Whole Exome Sequencing (WES) |
|---|---|---|
| Clinical Focus | Single‑gene precision for EIEE28 | Broad genomic survey, incidental findings |
| Methodology | Targeted NGS + Sanger confirmation | Untargeted NGS, may miss deep intronic variants |
| Analytical Sensitivity | >99.9% | ~95–98% depending on coverage |
| Turnaround Time | 3–4 weeks | 6–8 weeks |
| Price (AED) | 2800 | 5000+ |
Physician Insight & Safety Protocols
“Early and precise genetic diagnosis of EIEE28 empowers families to make informed decisions about seizure management and prognosis. This targeted test eliminates the uncertainty of broad genomic screening and provides actionable results that can reduce the burden of repeated investigations. I always emphasise that a confirmed molecular diagnosis is the first step toward personalised care and accurate recurrence risk counselling.”
— Lina Osama Zaki Quteineh, Consultant Medical Genetics, DHA Registration ID: 9294403
Advisory: Medication Safety
⚠ Medication Warning:
Do not discontinue or alter any prescribed antiepileptic or anti‑seizure medication without direct consultation with your treating neurologist. Abrupt withdrawal can trigger life‑threatening status epilepticus. Always seek medical advice before making changes.
Exclusion Criteria & Emergency Red Flags
- Testing of asymptomatic minors without explicit parental consent (per UAE Federal Decree‑Law No. 4 of 2016 on Medical Liability).
- Incomplete pre‑test genetic counselling documentation or lack of informed consent.
- Unlabelled, haemolysed, clotted, or improperly collected specimens (e.g., insufficient dried blood spot).
- Prolonged seizure >5 minutes or recurrent clusters – call 998 immediately.
- New‑onset respiratory distress, cyanosis, or unresponsiveness.
- Signs of metabolic crisis (vomiting, lethargy, hypoglycaemia) – seek emergency care.
Patient FAQ & Clinical Guidance
1. What is the WWOX gene and why is this test ordered?
The WWOX NGS test detects pathogenic variants in the WWOX gene responsible for early infantile epileptic encephalopathy type 28 (EIEE28) with >99.9% analytical sensitivity. It is ordered when an infant presents with drug‑resistant seizures, developmental regression, and EEG showing burst‑suppression or hypsarrhythmia, to confirm the molecular diagnosis and guide precise management.
2. How is the sample collected and does it require fasting?
Our VIP paediatric phlebotomy team collects a small blood sample (EDTA tube) or a painless dried blood spot via finger/heel prick in the comfort of your home—no fasting is required. Samples are transported at 2–8°C using validated cold‑chain logistics to maintain DNA integrity until processing.
3. What is the result turnaround time and what happens after a positive report?
The complete WWOX gene sequencing report is delivered within 3–4 weeks, clearly classifying any variant as pathogenic, likely pathogenic, or uncertain significance according to ACMG guidelines. A positive result triggers a complimentary tele‑consultation with our clinical genetics team, who will explain the prognosis, tailor the antiepileptic regimen, and facilitate cascade testing for at‑risk family members.
UAE Regulatory & Data Privacy Adherence
Data Protection & Health Information Privacy: This test adheres to Federal Decree‑Law No. 45 of 2021 on Personal Data Protection (PDPL) and Federal Law No. 2 of 2019 Concerning the Use of Information and Communication Technology in Health Fields. All genetic and clinical data are encrypted, access‑controlled, and processed solely for diagnostic purposes with explicit patient consent.
Medical Liability & Clinical Safety: The testing protocol complies with Federal Decree‑Law No. 4 of 2016 on Medical Liability, ensuring that clinical procedures, pre‑test counselling, and informed consent meet the highest legal and ethical standards.
Clinical & Logistical Metadata
| Test Name | WWOX Gene NGS Test for Early Infantile Epileptic Encephalopathy Type 28 (EIEE28) |
| Price (AED) | 2800 |
| Turnaround Time | 3–4 weeks |
| Sample Type / Matrix | Peripheral whole blood (EDTA) or dried blood spot; VIP Mobile Phlebotomy & Temperature-Controlled Cold-Chain Home Collection (8 AM–11 PM daily) |
| Methodology Used | Targeted Next‑Generation Sequencing (NGS) with Sanger confirmation |
| ICD-10-CM Code | G40.4 (Other generalized epilepsy and epileptic syndromes) |
| LOINC Code | 81329-4 (WWOX gene targeted mutation analysis) |
| DHA Facility License & Address | License No: 1143 | Premises 105, Floor 1, Building 33, Dubai Healthcare City, Dubai, UAE — DNA Labs UAE |
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Available in Arabic, English, Hindi & Urdu
ISMS 27001:2022
ISO Accredited
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All reports reviewed by DHA-Certified physicians