Test Price
2,800 AED✅ Home Collection Available
APP Gene Alzheimer Disease Type 1 Genetic Test in UAE | 2,800 AED | DHA Licensed
Executive Summary & Core Metrics
Executive Summary: Next-generation sequencing of the APP gene with 99.9% diagnostic sensitivity, fully accredited and DHA-licensed for early-onset familial Alzheimer's disease assessment.
- Accuracy Guarantee: 99.9% Diagnostic Sensitivity via ISO 9001:2015 (Cert: INT/EGQ/2509DA/3139) accredited processing.
- Premium Logistics: VIP Mobile Phlebotomy & Temperature-Controlled Cold-Chain Home Collection available daily from 8 AM to 11 PM.
- Clinical Guidance: Telephonic Post-Test Genetic Counselling by a Consultant Medical Geneticist.
- Insurance: Direct Billing Verification via WhatsApp +971 54 548 8731.
Test Overview & Methodology
The APP Gene Alzheimer disease type 1 genetic test employs next-generation sequencing to detect pathogenic mutations in the amyloid precursor protein gene, enabling precise diagnosis of early-onset familial Alzheimer's disease. The assay covers the full coding region of the APP gene with high-depth coverage, ensuring detection of all clinically relevant variants.
| Feature | Our Test (DNA Labs UAE) | Closest Alternative (Sanger Sequencing) |
|---|---|---|
| Methodology | NGS – 100% APP coding region coverage | Targeted Sanger – limited to known hotspots |
| Turnaround Time | 3–4 weeks | 6–8 weeks |
| Price (AED) | 2,800 | 3,500 |
| Regulatory Approval | DHA (License 1143) & ISO 9001:2015 | Varies; no mandatory UAE accreditation |
Physician Insight & Safety Protocols
Lina Osama Zaki Quteineh, Consultant Medical Genetics (DHA Registration ID: 9294403), emphasizes: "This genetic test provides critical risk information for early-onset familial Alzheimer's disease, but it must be interpreted alongside comprehensive neurological evaluation and detailed family pedigree analysis. A positive result indicates a pathogenic variant that significantly elevates lifetime risk, yet it does not confirm disease onset. Genetic counselling is indispensable before and after testing to ensure informed decision-making and appropriate clinical follow-up."
Medication Advisory
Medication Warning
Do not discontinue, adjust, or initiate any prescribed medication without consulting your treating physician. This genetic test is a screening tool and does not replace clinical judgment or ongoing therapeutic management.
Exclusion Criteria & Safety Red Flags
Exclusion Criteria
- Exclusion: Age under 18 years, pregnancy (unless clinically indicated and approved by a physician), inability to provide informed consent, or active treatment for acute neurological crisis.
Emergency Red Flags
- Sudden severe headache, stroke-like symptoms (facial droop, arm weakness, speech difficulty), new-onset seizure, or acute cognitive decline with altered consciousness — seek emergency medical care immediately.
- This service operates under Federal Decree-Law No. 4 of 2016 on Medical Liability for all clinical safety and patient consent procedures.
Patient FAQ & Clinical Guidance
1. What is the APP gene Alzheimer disease type 1 genetic test?
Answer: The APP gene test uses next-generation sequencing to detect mutations in the amyloid precursor protein gene that cause early-onset familial Alzheimer's disease. It identifies pathogenic variants with high precision, supporting diagnosis and familial risk assessment. Clinical correlation with neurological history is mandatory for result interpretation.
2. How is the sample collected for this genetic test?
Answer: A standard peripheral whole blood sample is collected via our VIP Mobile Phlebotomy service. Our trained team visits your home daily between 8 AM and 11 PM, using temperature-controlled cold-chain transport to preserve specimen integrity. A pre-collection genetic counselling session is recommended to construct a detailed pedigree chart and discuss implications.
3. What does a positive result mean?
Answer: A positive result indicates the presence of a pathogenic variant in the APP gene that significantly increases lifetime risk for early-onset Alzheimer's disease. It does not guarantee disease onset but warrants regular neurological follow-up and comprehensive genetic counselling for the patient and at-risk family members. Predictive testing in asymptomatic individuals requires careful pre-test counselling.
UAE Regulatory & Data Privacy Adherence
Regulatory Compliance & Data Protection
- DHA Licensed Facility: License Number 1143, issued by Dubai Health Authority. All genetic testing procedures comply with DHA clinical standards and UAE federal healthcare regulations.
- ISO 9001:2015 Certified: Certificate Number INT/EGQ/2509DA/3139, confirming rigorous quality management across pre-analytical, analytical, and post-analytical processes.
- Genetic Data Privacy: All genetic information is processed and stored in full compliance with Federal Decree-Law No. 45 of 2021 on Personal Data Protection (PDPL), ensuring that sensitive genomic data is protected against unauthorized access, disclosure, or misuse.
- Health ICT Compliance: All electronic health records and digital reporting systems adhere to Federal Law No. 2 of 2019 Concerning the Use of Information and Communication Technology in Health Fields, guaranteeing secure data transmission and interoperability.
Clinical & Logistical Metadata
| Test Name | APP Gene Alzheimer Disease Type 1 Genetic Test |
| Price (AED) | 2,800 AED |
| Turnaround Time | 3–4 weeks |
| Sample Type / Matrix | Peripheral whole blood (standard venipuncture). VIP Mobile Phlebotomy & Temperature-Controlled Cold-Chain Home Collection available daily from 8 AM to 11 PM. |
| Methodology Used | Next-Generation Sequencing (NGS) – full APP gene coding region coverage with high-depth analysis |
| ICD-10-CM Code | G30.0 |
| LOINC Code | 21645-4 |
| DHA Facility License & Laboratory Address | DHA License Number 1143 | DNA Labs UAE | Premises 105, Floor 1, Building 33, Dubai Healthcare City, Dubai, UAE |
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