Test Price
2,800 AED✅ Home Collection Available
TUBB Gene Neurodevelopmental Disorder NGS Test – Comprehensive Genetic Analysis
Executive Summary & Core Metrics
This comprehensive Next Generation Sequencing (NGS) test for the TUBB gene provides high-accuracy diagnosis of neurodevelopmental disorders associated with tubulinopathies. The analysis is conducted under ISO 9001:2015 certified protocols with rigorous quality control standards.
- Accuracy Guarantee: 99.9% Diagnostic Sensitivity via ISO Accredited Processing.
- Premium Logistics: VIP Mobile Phlebotomy & Temperature-Controlled Cold-Chain Home Collection available daily from 8 AM to 11 PM.
- Clinical Guidance: Telephonic Post-Test Clinical Guidance in result interpretation.
- Insurance: Direct Billing Verification via WhatsApp +971 54 548 8731.
Test Overview & Methodology
The TUBB Gene Neurodevelopmental Disorder NGS Test sequences the entire coding region of the TUBB gene to detect single nucleotide variants, small insertions/deletions, and copy number variations associated with cortical malformations and intellectual disability. This diagnostic approach is the gold standard for confirming tubulinopathy diagnoses, outperforming conventional single-gene sequencing by simultaneously assessing all coding exons with greater than 1000 times depth coverage.
| Feature | Our NGS Test | Conventional Single-Gene Sequencing |
|---|---|---|
| Precision | 99.9% sensitivity for all variant types including SNVs, indels, and CNVs | May miss large deletions, duplications, and deep intronic variants |
| Method | Next Generation Sequencing on Illumina NovaSeq platform, ISO certified | Sanger sequencing of selected exons only |
| Turnaround Time | 3 to 4 Weeks | 6 to 8 Weeks |
| Coverage | All coding exons plus flanking intronic regions with greater than 1000 times depth | Partial gene coverage with low sensitivity for mosaicism |
| Clinical Utility | Comprehensive mutation detection enabling targeted therapies and family screening | Basic sequence analysis often requiring additional testing for full diagnosis |
Physician Insight & Safety Protocols
Advisory & Clinical Guidance
Post-test telephonic clinical guidance is included with every report. Our genetics team will contact you after results are ready to discuss the clinical correlation and outline recommended next steps for medical management or family screening.
Safety Exclusion Criteria & Emergency Red Flags
- Exclusion Criteria: Individuals under 18 years without legal guardian consent as per Federal Decree-Law No. 4 of 2016 on Medical Liability; patients with active febrile illness or severe coagulopathy precluding blood draw; lack of documented clinical suspicion of a TUBB-related disorder.
- Emergency Red Flags: Seek immediate medical attention if you or your child experience new-onset seizures, acute loss of developmental milestones, severe headache with vomiting, or altered consciousness.
Patient FAQ & Clinical Guidance
1. What does the TUBB NGS test detect and who should consider it?
This test detects pathogenic variants in the TUBB gene causing neurodevelopmental disorders and brain malformations. It is recommended for individuals with unexplained intellectual disability, cortical dysplasia, epilepsy, or lissencephaly spectrum. A pediatric neurologist or clinical geneticist should evaluate eligibility to ensure the highest diagnostic yield and appropriate pre-test counseling.
2. Do I need genetic counseling before the test and how is the sample collected?
Yes, pre-test genetic counseling is mandatory to document family history and obtain informed consent. A certified genetic counselor will draw a pedigree chart and explain potential outcomes. The sample is collected via a standard peripheral blood draw using our VIP Mobile Phlebotomy service available daily from 8 AM to 11 PM.
3. What do positive results mean for treatment and future family planning?
Positive results confirm a tubulinopathy diagnosis, guiding targeted therapy, seizure management, and reproductive counselling. A confirmed TUBB mutation allows clinicians to select appropriate antiepileptic drugs, developmental therapies, and provide precise recurrence risks for family members. Post-test telephonic interpretation is included with every report to discuss clinical correlation and next steps.
4. How long does it take to get results and how will I receive them?
The standard turnaround time for this test is 3 to 4 weeks from sample receipt at the laboratory. Results are delivered electronically through a secure patient portal, and a hard copy can be issued upon request. You will receive a telephone consultation with our genetics team to interpret the findings.
UAE Regulatory & Data Privacy Adherence
Data Privacy & Security: All patient data is processed in full compliance with Federal Decree-Law No. 45 of 2021 on Personal Data Protection (PDPL) and Federal Law No. 2 of 2019 Concerning the Use of Information and Communication Technology in Health Fields. Clinical testing safety and patient consent procedures adhere to Federal Decree-Law No. 4 of 2016 on Medical Liability.
Accreditation: The laboratory is ISO 9001:2015 certified under certificate number INT/EGQ/2509DA/3139. All clinical procedures follow international standards for genetic testing and molecular diagnostics.
Clinical & Logistical Metadata
| Test Name | TUBB Gene Neurodevelopmental Disorder NGS Test |
| Price (AED) | 2,800 |
| Turnaround Time | 3 to 4 Weeks |
| Sample Type / Matrix | Whole Blood (peripheral) collected via VIP Mobile Phlebotomy service |
| Methodology Used | Next Generation Sequencing (NGS) on Illumina NovaSeq platform |
| ICD-10-CM Code | Q04.8, F70, G40.909 |
| LOINC Code | 92738-5 |
| DHA Facility License & Laboratory Address | DHA Facility License Number: 1143 | Premises 105, Floor 1, Building 33, Dubai Healthcare City, Dubai, UAE – DNA Labs UAE |
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Available in Arabic, English, Hindi & Urdu
ISMS 27001:2022
ISO Accredited
HIPAA
All reports reviewed by DHA-Certified physicians