Test Price
2,800 AED✅ Home Collection Available
TMEM240 Gene Spinocerebellar Ataxia Type 21, Autosomal Dominant Genetic Test in UAE | 2,800 AED | 2026 DHA Guidelines
تحليل الجين TMEM240 للرنح النخاعي المخيخي من النوع 21 (الوراثة السائدة) بتقنية التسلسل الجيني (NGS) في الإمارات | 2800 درهم | معتمد من هيئة الصحة بدبي
ملخص تنفيذي: يضمن هذا الاختبار دقة تشخيصية تصل إلى 99.9% باستخدام تقنية التسلسل الجيني القياسية المعتمدة وفقاً لمواصفة الآيزو 9001:2015. تتوفر خدمة جمع العينات المنزلية عبر فريق تمريض متنقل ضمن سلسلة تبريد معتمدة، تعمل يومياً من 8 صباحاً حتى 11 مساءً. بعد صدور النتيجة، نقدم استشارة طبية هاتفية لتفسيرها. للتحقق من تغطية التأمين الصحي ومطالبات التغطية المباشرة، تواصل معنا عبر واتساب على الرقم 971545488731+.
Overview
The TMEM240 NGS test is a targeted next‑generation sequencing analysis that identifies pathogenic variants in the TMEM240 gene, the definitive molecular cause of spinocerebellar ataxia type 21, an autosomal dominant neurodegenerative disorder. This advanced genomic test replaces older single‑gene methods, offering complete exon coverage and rapid 3‑4 week turnaround for precise clinical decision‑making.
هذا الاختبار الجيني المتطور يقارن بين تقنيتنا المثلى والبديل الأقرب، كما هو موضح في الجدول أدناه.
| Parameter | Our TMEM240 NGS Test | Sanger Sequencing (Alternative) |
|---|---|---|
| Precision & Coverage | Full gene sequencing (exons ± flanking regions) with variant allele frequency down to 5% | Single amplicon analysis, limited to known mutation hotspots |
| Methodology | Next‑Generation Sequencing (NGS) validated to ISO 9001:2015 | Capillary electrophoresis; lower throughput |
| Turnaround Time | 3‑4 Weeks (DNA extraction to clinical report) | 6‑8 Weeks (limited lab capacity) |
| Clinical Utility | Confirmation of clinical diagnosis, presymptomatic testing, family planning | Often inadequate for full gene screening |
Test ordered primarily by: Neurologist, Clinical Geneticist, and Genetic Counselor for hereditary ataxia management.
Physician Insight & Safety Protocol
“This TMEM240 gene test is a powerful tool for establishing a molecular diagnosis of spinocerebellar ataxia type 21, yet its results must always be correlated with comprehensive neurological examination and family history. A negative report does not exclude other genetic or non‑genetic causes of ataxia, and I strongly recommend post‑test genetic counselling to fully interpret the findings.”
— Dr. PRABHAKAR REDDY, DHA License: 61713011
Critical Safety Information
- Exclusion Criteria: This test is not suitable for minors without legal guardian consent (per CDS Law 2026) or for patients undergoing acute neurological emergencies where immediate imaging is required.
- ER Red Flags: Seek emergency care immediately if you experience sudden loss of consciousness, epileptic seizures, acute vision loss, or severe new‑onset headache.
- Medication Warning: Do not discontinue any prescribed medication without consulting your treating physician, even if test results are negative.
All testing complies with UAE Federal Decree‑Law No. 41 of 2024 (Art. 87), CDS Law 2026 (minors), and UAE PDPL data privacy standards. Facility License: 9834453 | ISO 9001:2015 Cert: INT/EGQ/2509DA/3139.
Patient FAQ & Clinical Guidance
What is the TMEM240 gene test for spinocerebellar ataxia type 21?
Next‑generation sequencing identifies TMEM240 gene mutations causing spinocerebellar ataxia type 21, an autosomal dominant condition. This test analyses the complete coding region of the gene to detect single‑nucleotide variants, small insertions/deletions, and copy‑number changes that lead to progressive cerebellar degeneration. Because SCA21 is inherited in an autosomal dominant pattern, a single mutated copy of the gene is sufficient to cause disease; the test can confirm a clinical diagnosis, guide prognosis, and inform reproductive choices for at‑risk family members.
يقوم اختبار التسلسل الجيني من الجيل التالي بتحليل جين TMEM240 لتحديد الطفرات المسببة للرنح النخاعي المخيخي من النوع 21 الوراثي السائد، مما يساعد في تأكيد التشخيص وتوجيه الاستشارة الوراثية.
How should I prepare for the test and what does the home collection include?
No fasting or special preparation is required; our VIP phlebotomy team visits your home for a painless blood draw. You may also provide a dried blood spot on an FTA card if venous access is difficult. The entire collection takes less than 15 minutes, and samples are transported in ISO‑certified cold‑chain containers to our laboratory. A pre‑test genetic counselling session (included in the price) will be arranged to obtain your detailed family pedigree, ensuring accurate interpretation of the results. You can schedule the visit any day between 8 AM and 11 PM.
لا يحتاج الاختبار إلى صيام أو تحضير خاص؛ يقوم فريقنا التمريضي بزيارة منزلية لأخذ عينة دم بسيطة، وتُنقل العينات في حافظات مبردة معتمدة لضمان سلامتها.
What happens after I receive my TMEM240 test results?
Post‑ telephone guidance with a specialist explains your result in the context of your clinical history. If a pathogenic variant is identified, the report will detail the exact mutation, its known disease association, and implications for family members. A negative result may still warrant further evaluation for other ataxia genes; we can coordinate reflex testing upon your neurologist’s request. For reproductive planning, carrier screening of partners and prenatal options can be discussed during the consultation. All data is protected under UAE PDPL and is never shared without your explicit consent.
بعد النتيجة، تقدم استشارة هاتفية لتفسير التقرير في سياق تاريخك الطبي، مع خيار تمديد الفحص لجينات أخرى إذا لزم الأمر، مع الالتزام بخصوصية البيانات.
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