Test Price
2,800 AEDโ Home Collection Available
๐ Results in 3โ4 Weeks
HTT Gene Huntington Disease Genetic Test (NGS) in UAE | 2800 AED | DHA Guidelines
Executive Summary & Core Metrics
This sophisticated genetic test analyzes CAG trinucleotide repeat expansions in the HTT gene to diagnose Huntington disease (HD) or assess presymptomatic genetic risk. It offers 99.9% diagnostic sensitivity through ISO-certified Next-Generation Sequencing protocols validated by DNA Labs UAE.
- Diagnostic Accuracy: 99.9% sensitivity for CAG repeat sizing and rare allele detection via ISO 9001:2015 certified processing.
- Premium Logistics: VIP Mobile Phlebotomy & Temperature-Controlled Cold-Chain Home Collection available daily from 8 AM to 11 PM.
- Clinical Guidance: Telephonic post-test consultation for expert interpretation of CAG repeat results and neurological risk stratification.
- Insurance & Billing: Direct billing verification available via WhatsApp at +971 54 548 8731.
Test Overview & Methodology
Test Overview
The HTT Gene NGS Test detects CAG repeat expansions in the huntingtin gene to diagnose Huntington disease (HD) or evaluate genetic predisposition. Using a combination of next-generation sequencing and confirmatory high-resolution PCR, the test provides precise sizing of CAG repeats and identifies interrupted or atypical variants that conventional fragment analysis may miss. Results are reported alongside a comprehensive clinical interpretation aligned with DHA guidelines for neurogenetic testing.
| Feature | Our Test (NGS) | Closest Alternative (Standard PCR) |
|---|---|---|
| Precision | 99.9% sensitivity with full CAG sizing and rare allele detection | Approximately 95% sensitivity; may miss interrupted or atypical repeat variants |
| Method | Next-Generation Sequencing + Confirmatory HighโResolution PCR | Fragment analysis PCR only |
| Speed | 3โ4 weeks with comprehensive clinical interpretation | 2โ3 weeks (standard lab) |
| Clinical Depth | Detailed, DHAโaligned report with ICARSโbased motor assessment notes | Basic CAG repeat number only |
Physician Insight & Safety Protocols
As a Consultant in Medical Genetics specializing in neurogenetic disorders, I emphasize that accurate interpretation of CAG repeat expansions for Huntington disease requires comprehensive clinical correlation and strict adherence to pre- and post-test genetic counseling protocols. A result indicating 40 or more CAG repeats confirms the diagnosis, while intermediate alleles (27โ35) or reduced penetrance alleles (36โ39) require careful family history analysis and neurological evaluation. This NGS-based assay provides the granularity needed for such precise risk stratification.
โ Lina Osama Zaki Quteineh | Consultant Medical Genetics | DHA Registration ID: 9294403
Clinical Notice: Medication Advisory
Do not alter or suspend prescribed treatments without explicit consultation with your managing physician. Abrupt discontinuation of medications, particularly those managing chorea, psychiatric symptoms, or other neurological manifestations, may induce unpredictable clinical effects or exacerbate underlying disease progression.
Exclusion Criteria & Emergency Red Flags
- Exclusion Criteria: Individuals under 18 years of age without explicit medical justification and guardian consent per UAE pediatric genetic testing regulations; acute psychiatric instability or inability to provide informed consent; current participation in experimental HD clinical trials without prior coordination with your primary neurologist.
- Emergency Red Flags: Sudden worsening of chorea, new-onset seizure activity, acute suicidal ideation, or rapid cognitive decline during the testing process requires immediate medical attention at the nearest emergency department. Do not delay treatment while awaiting test results.
Patient FAQ & Clinical Guidance
1. Who should consider the HTT gene Huntington disease test?
Adults with a documented family history of Huntington disease or those presenting with suggestive motor (chorea, dystonia), cognitive (executive dysfunction), or psychiatric (depression, irritability) symptoms should undergo genetic testing accompanied by formal pre-test counseling. Predictive testing for asymptomatic adults with a family history is also available under strict ethical protocols.
2. What does a positive HTT gene test result mean?
A positive result indicates an expanded CAG repeat count of 40 or greater, confirming the diagnosis of Huntington disease or confirming high genetic risk in presymptomatic individuals. Alleles in the reduced penetrance range (36โ39 CAG repeats) may or may not cause symptoms in a lifetime and require correlation with clinical presentation and family history.
3. How accurate is this genetic test for Huntington disease?
This NGS-based assay offers 99.9% diagnostic sensitivity for detecting CAG repeat expansions in the HTT gene. It is validated against ISO 9001:2015 certified protocols and includes confirmatory high-resolution PCR to resolve ambiguous cases, such as intermediate alleles or rare sequence interruptions.
UAE Regulatory & Data Privacy Adherence
Your genetic data and personal health information are processed under strict UAE data protection frameworks. DNA Labs UAE adheres to Federal Decree-Law No. 45 of 2021 on Personal Data Protection (PDPL) and Federal Law No. 2 of 2019 Concerning the Use of Information and Communication Technology in Health Fields to ensure secure handling, storage, and transmission of genomic data. Clinical testing safety and informed consent protocols operate under Federal Decree-Law No. 4 of 2016 on Medical Liability, which governs pre- and post-test genetic counseling standards. DNA Labs UAE holds DHA Facility License No. 1143 and is fully compliant with Dubai Healthcare City quality regulations.
Clinical & Logistical Metadata
| Test Name | HTT Gene Huntington Disease Genetic Test (NGS) |
| Price (AED) | 2,800 AED |
| Turnaround Time | 3โ4 Weeks |
| Sample Type / Matrix | EDTA Whole Blood |
| Methodology Used | Next-Generation Sequencing (NGS) & Confirmatory High-Resolution PCR |
| ICD-10-CM Code | G10 |
| LOINC Code | 21669-3 |
| DHA Facility License & Laboratory Address | DHA License: 1143 Premises 105, Floor 1, Building 33 Dubai Healthcare City, Dubai, UAE Lab: DNA Labs UAE |
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Medically Reviewed by Dr. Lina Osama Zaki Quteineh
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ISMS 27001:2022
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