Test Price
2,800 AED✅ Home Collection Available
EIF2B1 Gene Leukoencephalopathy with Vanishing White Matter Genetic Test in UAE | 2,800 AED
Executive Summary & Core Metrics
Our DHA-licensed laboratory provides the definitive EIF2B1 Genetic Test with 99.9% diagnostic sensitivity for vanishing white matter disease (VWM). We offer VIP mobile phlebotomy and temperature-controlled cold-chain home collection across the UAE (8 AM – 11 PM). Direct post-test genetic counselling is included. Verify insurance coverage instantly via WhatsApp: +971 54 548 8731.
Test Overview & Methodology
This advanced DNA test sequences the entire coding region of the EIF2B1 gene using Next Generation Sequencing (NGS) to detect pathogenic mutations linked to childhood ataxia with central nervous system hypomyelination/vanishing white matter disease (VWM). It offers vital insights for molecular diagnosis, carrier detection, and informed family planning in suspected leukodystrophy cases.
| Feature | Our DHA-Certified Test | Closest Alternative (Sanger) |
|---|---|---|
| Methodology | NGS (full gene sequencing, all exons + splice sites) | Sanger sequencing (known hotspot regions only) |
| Precision | 99.9% analytical sensitivity/specificity | Limited to preselected mutations |
| Turnaround Time | 3 – 4 weeks | 2 – 3 weeks (faster but narrower) |
| Cost (AED) | 2,800 AED | ~2,200 – 2,500 AED (limited scope) |
Physician Insight & Safety Protocols
From Lina Osama Zaki Quteineh, Consultant Medical Genetics (DHA Registration ID: 9294403): “As a medical geneticist, I understand the profound anxiety that genetic testing for a rare leukodystrophy can bring. This NGS assay provides a definitive molecular diagnosis crucial for accurate prognostication, family counselling, and guiding potential disease-modifying interventions. I strongly recommend integrating these results with a comprehensive clinical evaluation and a dedicated genetic counselling session.”
Medication Advisory
Do not discontinue any prescribed medications or therapies without first consulting your treating physician, as abrupt changes may worsen neurological status.
Patient Safety & Exclusion Criteria
- This test is not intended for asymptomatic minors without clinical suspicion and informed parental consent, in compliance with Federal Decree-Law No. 4 of 2016 on Medical Liability.
- It is not a standalone screening tool; negative or ambiguous results must be correlated by a neurologist.
- Emergency red flags: If you experience acute deterioration, seizures, loss of consciousness, or sudden vision changes, seek immediate emergency medical attention — do not wait for test results.
- Individuals without a verified clinical history or family pedigree suggestive of VWM should first undergo neurological and genetic counselling.
Patient FAQ & Clinical Guidance
1. Who should consider this EIF2B1 gene test?
Individuals with unexplained progressive ataxia, spasticity, and brain MRI showing diffuse white matter rarefaction, or those with a known family history of vanishing white matter disease, should consider this test to confirm the diagnosis and enable genetic counseling.
2. How accurate is NGS for detecting EIF2B1 mutations?
Our NGS assay achieves >99.9% analytical sensitivity and specificity, comprehensively sequencing all coding exons and splice junctions, ensuring reliable detection of pathogenic variants.
3. How long until results and what support is provided?
Results are available in 3-4 weeks; our service includes a post-test telephonic clinical guidance session with a certified genetic counselor to interpret findings and discuss next steps.
UAE Regulatory & Data Privacy Adherence
Legal Compliance Framework
Our laboratory adheres to Federal Decree-Law No. 45 of 2021 on Personal Data Protection (PDPL) and Federal Law No. 2 of 2019 Concerning the Use of Information and Communication Technology in Health Fields. Patient data is encrypted and handled in accordance with DHA standards. All genetic counselling and sample logistics comply with MOHAP regulations.
Clinical & Logistical Metadata
| Test Name | EIF2B1 Gene Full Sequencing (Vanishing White Matter Disease) |
| Price (AED) | 2,800 AED |
| Turnaround Time | 3 – 4 weeks |
| Sample Type / Matrix | Peripheral whole blood (EDTA tube) – VIP Mobile Phlebotomy & Temperature-Controlled Cold-Chain Home Collection available daily from 8 AM to 11 PM. |
| Methodology Used | Next Generation Sequencing (NGS) – full gene sequencing including all exons and splice sites |
| ICD-10-CM Code | G93.8 (Other specified disorders of brain) |
| LOINC Code | 94047-7 |
| DHA Facility License & Laboratory Address | License 1143 – Premises 105, Floor 1, Building 33, Dubai Healthcare City, Dubai, UAE | Corporate: DNA Labs UAE |
دعم ثنائي اللغة متاح
التحقق من التغطية التأمينية
Check Insurance Coverage Instantly
Stop the guesswork. Send a photo of your Insurance Card and Doctor's Prescription to our DHA-Certified Verification Team on WhatsApp.
توقف عن التخمين. أرسل صورة من بطاقة التأمين ووصفة الطبيب إلى فريق التحقق المعتمد من هيئة الصحة بدبي عبر الواتساب. احصل على تحديث الحالة في دقائق.
Available in Arabic, English, Hindi & Urdu
ISMS 27001:2022
ISO Accredited
HIPAA
All reports reviewed by DHA-Certified physicians