Test Price
2,800 AED✅ Home Collection Available
DCTN1 Gene Test for Distal Hereditary Motor Neuropathy Type 7B (HMN7B) – 2800 AED
Executive Summary & Core Metrics
- 99.9% Diagnostic Sensitivity via ISO 9001:2015 (Cert: INT/EGQ/2509DA/3139) accredited Next-Generation Sequencing (NGS) processing.
- Premium Logistics: VIP Mobile Phlebotomy & Temperature-Controlled Cold-Chain Home Collection (Available daily from 8 AM to 11 PM).
- Clinical Guidance: Dedicated telephonic post-test interpretation provided by our Consultant Medical Geneticist and certified genetic counsellor.
- Insurance: Direct billing verification and pre-authorization assistance via WhatsApp +971 54 548 8731.
Test Overview & Methodology
The DCTN1 NGS test screens for pathogenic variants in the DCTN1 gene, confirming distal hereditary motor neuropathy type VIIB and guiding family planning. This comprehensive analysis utilizes Next-Generation Sequencing to provide unparalleled accuracy.
| Feature | Our DCTN1 NGS Test | Alternative (Sanger Sequencing) |
|---|---|---|
| Precision | >99.9% sensitivity, full gene coverage with CNV detection | ~95% limited to known hotspots, no CNV analysis |
| Methodology | NGS (Illumina® platform), complete DCTN1 gene ± MLPA | Sanger sequencing of coding exons only |
| Turnaround Time | 3-4 weeks | 6-8 weeks |
| Price | 2,800 AED | 3,500+ AED |
Physician Insight & Safety Protocols
“As a Consultant in Medical Genetics, I emphasize that the DCTN1 genetic test provides definitive molecular confirmation for HMN7B. However, accurate interpretation relies heavily on comprehensive clinical phenotyping and detailed pedigree analysis. It is imperative to correlate these results with electrophysiological studies and a thorough neurological examination before drawing final conclusions on prognosis or therapeutic management.”
– Lina Osama Zaki Quteineh, Consultant Medical Genetics, DHA Registration ID: 9294403
Medication & Clinical Advisory
Critical Note: Do not discontinue, alter, or pause any prescribed neurological medications without direct consultation with your managing physician. Abrupt cessation of therapy can lead to rapid clinical deterioration and decompensation.
Exclusion Criteria & Emergency Red Flags
- Acute febrile illness or uncontrolled systemic infection.
- Inability to provide informed consent (mandatory pre-test genetic counselling session).
- Minors without fully informed parental or guardian consent, strictly adhering to UAE Federal Laws.
- Severe haemodynamic instability or coagulopathy precluding safe venipuncture.
- Red Flags: New-onset respiratory muscle weakness, acute dysphagia, or signs of aspiration pneumonia – these constitute medical emergencies. Seek immediate evaluation at the nearest hospital emergency department.
Patient FAQ & Clinical Guidance
1. What specific mutations does the DCTN1 gene test detect for HMN7B?
The test employs Next-Generation Sequencing (NGS) to identify pathogenic single nucleotide variants, insertions, deletions, and copy number variations across the entire coding region of the DCTN1 gene. This provides a definitive molecular diagnosis for Distal Hereditary Motor Neuropathy Type 7B, distinguishing it from other motor neuron diseases and guiding accurate family planning and risk assessment.
2. What is the turnaround time and what specimen types are accepted?
Results are typically available within 3-4 weeks from sample receipt. Accepted specimen matrices include: Peripheral Whole Blood (EDTA tube), Extracted DNA (high-quality, quantified), or a Dried Blood Spot on an FTA card. Our VIP Mobile Phlebotomy service ensures proper sample acquisition and Temperature-Controlled Cold-Chain transport to our ISO 9001:2015 accredited laboratory.
3. Is this test covered by UAE insurance and is genetic counselling mandatory?
Yes, most UAE insurance providers offer coverage for this diagnostic test following a successful pre-authorization request. Our team handles the direct billing verification process via WhatsApp at +971 54 548 8731. In full compliance with UAE Federal Decree-Law No. 4 of 2016 on Medical Liability, a mandatory pre-test genetic counselling session with our certified specialist is required to ensure informed consent, explain inheritance patterns, and draw a comprehensive pedigree chart. Post-test counselling is seamlessly integrated into the service.
UAE Regulatory & Data Privacy Adherence
Regulatory Compliance Framework: This genetic test is performed in strict accordance with the UAE Federal Decree-Law No. 45 of 2021 on Personal Data Protection (PDPL) and Federal Law No. 2 of 2019 Concerning the Use of Information and Communication Technology in Health Fields. All clinical procedures adhere to the standards set forth in Federal Decree-Law No. 4 of 2016 on Medical Liability. The laboratory operates under DHA Facility License No. 1143, located at Premises 105, Floor 1, Building 33, Dubai Healthcare City, Dubai, UAE, and is ISO 9001:2015 Certified (Cert: INT/EGQ/2509DA/3139).
Clinical & Logistical Metadata
| Test Name | DCTN1 Gene Full Mutation Analysis (Distal Hereditary Motor Neuropathy Type 7B) |
| Price (AED) | 2,800 AED |
| Turnaround Time | 3-4 Weeks |
| Sample Type / Matrix | Peripheral Whole Blood (EDTA), Extracted DNA, or Dried Blood Spot (FTA Card) |
| Methodology Used | Next-Generation Sequencing (NGS) – Illumina Platform with Bioinformatics Confirmation |
| ICD-10-CM Code | G12.29, G60.0, Z84.81 |
| LOINC Code | 94059-9 |
| DHA Facility License & Address | DHA License No: 1143 | Premises 105, Floor 1, Building 33, Dubai Healthcare City, Dubai, UAE |
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