Test Price
2,800 AED✅ Home Collection Available
COASY Gene Neurodegeneration with Brain Iron Accumulation Type 6 Genetic Test in UAE | 2800 AED
Executive Summary & Core Metrics
Accuracy Guarantee: 99.9% Diagnostic Sensitivity (NGS depth > 100x) via ISO 9001:2015 Certified Processing (Cert: INT/EGQ/2509DA/3139).
Premium Logistics: VIP Mobile Phlebotomy & Temperature-Controlled Cold-Chain Home Collection (Available daily from 8 AM to 11 PM).
Clinical Guidance: Telephonic post-test clinical guidance in result interpretation by DHA-licensed Consultant Medical Geneticist.
Insurance: Direct Billing Verification via WhatsApp +971 54 548 8731 – dedicated pre‑approval support.
Executive Summary: Comprehensive COASY gene sequencing with 99.9% accuracy for NBIA6 diagnosis, including licensed home collection and post-test genetic counselling by DHA-registered specialists.
Test Overview & Methodology
The COASY NGS test identifies pathogenic variants in the COASY gene, which cause Neurodegeneration with Brain Iron Accumulation Type 6 (NBIA6). This rare autosomal recessive disorder leads to progressive iron deposition in the basal ganglia, resulting in dystonia, spasticity, and cognitive decline. Our targeted next-generation sequencing assay covers 100% of coding exons and flanking intronic regions (±10 bp) with a minimum depth of 100x, followed by Sanger confirmation of clinically significant variants.
| Feature | Our COASY NGS Test | Closest Alternative (Whole Exome Sequencing) |
|---|---|---|
| Precision | Targeted coverage > 99.9% of COASY coding exons ±10 bp | Broad but may miss splice-site variants, lower depth |
| Methodology | NGS with Sanger confirmation of pathogenic variants | NGS with variant filtering, high incidental findings rate |
| Turnaround Time | 3–4 Weeks | 6–12 Weeks |
| Clinical Actionability | Immediate integration with NBIA6 clinical pathway | Requires additional bioinformatics interpretative steps |
| Cost (UAE) | 2800 AED | 6000–8000 AED |
Physician Insight & Safety Protocols
"A positive COASY mutation must be interpreted in conjunction with the full clinical picture, brain MRI (T2* GRE/hypointensity in globus pallidus), and neurological examination. I recommend integrating genetic results with disease‑specific registries and clinical trial opportunities for affected individuals. A negative result does not exclude other forms of neurodegeneration."
"Patients should never discontinue prescribed neuroprotective or symptomatic therapies without consulting their neurologist, as abrupt withdrawal may provoke severe spasticity or dystonic storms. This test is a guidepost, not a replacement for ongoing multidisciplinary care."
"Early diagnosis in paediatric or young adult patients enables timely enrolment in disease‑specific registries and future clinical trial screening, making prompt testing essential."
— Lina Osama Zaki Quteineh, Consultant Medical Genetics, DHA Registration ID: 9294403
Advisory: Medication Safety Notice
⚠ Do not discontinue prescribed medication without consulting your doctor.
Abrupt withdrawal of antispasticity agents (e.g., baclofen) or dopamine‑blocking drugs can lead to life‑threatening dystonic storms or neuroleptic malignant syndrome. Always maintain current therapy and discuss any changes with your neurologist.
Exclusion Criteria & Emergency Red Flags
- Exclusion from home collection: Active febrile illness, haemodynamic instability, or inability to provide informed consent (legal guardian required for minors per Federal Decree-Law No. 4 of 2016 on Medical Liability).
- Sample rejection risk: Blood collected within 90 days after whole blood transfusion or stem cell infusion (donor DNA may confound results).
- ER Red Flags – seek immediate care if you experience: Sudden worsening of dystonia, new‑onset seizures, respiratory compromise, or altered consciousness. These may indicate metabolic crisis or intracranial pressure changes.
Patient FAQ & Clinical Guidance
1. Why is the COASY gene test ordered for brain iron accumulation?
This NGS test detects COASY pathogenic variants to confirm Neurodegeneration with Brain Iron Accumulation Type 6 in patients with progressive dystonia and characteristic MRI findings. It differentiates NBIA6 from other forms like PKAN or PLA2G6‑associated neurodegeneration, guiding precise management and family genetic counselling.
2. How should I prepare for the COASY DNA test and what sample is needed?
You need a clinical history review, a genetic counselling session to draw a pedigree chart, and a simple blood draw or FTA card spot. No fasting is required; continue prescribed medications unless your neurologist advises otherwise. Our mobile phlebotomist collects 2–3 ml whole blood in EDTA tube, or you may submit extracted DNA – all handled via cold‑chain.
3. What does a negative COASY test result mean and what are my next steps?
A negative report means no pathogenic COASY variant was identified, lowering NBIA6 probability but not ruling out other neurodegenerative disorders. Your neurologist may recommend broader NBIA panel testing, mitochondrial DNA studies, or repeat MRI with susceptibility‑weighted imaging to evaluate for other iron‑accumulating conditions.
UAE Regulatory & Data Privacy Adherence
Data Privacy & Legal Compliance
- All genetic data is processed in full compliance with Federal Decree-Law No. 45 of 2021 on Personal Data Protection (PDPL).
- Health information handling follows Federal Law No. 2 of 2019 Concerning the Use of Information and Communication Technology in Health Fields.
- Patient safety and consent are governed by Federal Decree-Law No. 4 of 2016 on Medical Liability.
- Laboratory operations are ISO 9001:2015 certified (Cert: INT/EGQ/2509DA/3139).
Clinical & Logistical Metadata
| Test Name | COASY Gene Neurodegeneration with Brain Iron Accumulation Type 6 Genetic Test |
| Price (AED) | 2,800 AED |
| Turnaround Time | 3 – 4 Weeks |
| Sample Type / Matrix | Whole Blood (EDTA), Extracted DNA (≥1 µg), or FTA Card spot |
| Methodology Used | Targeted NGS with Sanger confirmation |
| ICD-10-CM Code | G23.0 |
| LOINC Code | 21635-8 |
| DHA Facility License & Address | DHA License: 1143 | Premises 105, Floor 1, Building 33, Dubai Healthcare City, Dubai, UAE – DNA Labs UAE |
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