Test Price
2,800 AED✅ Home Collection Available
COASY Gene Neurodegeneration with Brain Iron Accumulation Type 6 Genetic Test in UAE | 2800 AED | 2026 DHA Guidelines
تحليل الجين COASY لأمراض التنكس العصبي مع تراكم الحديد في الدماغ من النوع 6 في الإمارات | 2800 درهم | معتمد من هيئة الصحة بدبي
Accuracy Guarantee: 99.9% Diagnostic Sensitivity (NGS depth > 100x) via ISO 9001:2015 Certified Processing (Cert: INT/EGQ/2509DA/3139).
Premium Logistics: Paid Hospital-Grade Home Collection via ISO Certified Cold-Chain Home Collection – VIP Mobile Phlebotomy (8 AM – 11 PM).
Clinical Guidance: Telephonic Post-Test Clinical Guidance in result interpretation by DHA-licensed Consultant Neurologist.
Insurance: Direct Billing Verification via WhatsApp +971 54 548 8731 – dedicated pre‑approval support.
ملخص تنفيذي: اختبار الجين COASY للكشف عن طفرات تراكم الحديد في الدماغ من النوع 6 بتقنية التسلسل الجيني المتقدم بدقة 99.9%، مع خدمة سحب منزلي مرخصة ومتابعة طبية هاتفية معتمدة من هيئة الصحة بدبي.
Overview
The COASY NGS test identifies pathogenic variants in the COASY gene, which cause Neurodegeneration with Brain Iron Accumulation Type 6 (NBIA6). This rare autosomal recessive disorder leads to progressive iron deposition in the basal ganglia, resulting in dystonia, spasticity, and cognitive decline. يقوم اختبار الجين COASY بتحديد الطفرات المسببة لمرض التنكس العصبي مع تراكم الحديد في الدماغ من النوع 6، وهو اضطراب وراثي نادر يتسبب في تراكم الحديد في العقد القاعدية وتدهور عصبي تقدمي.
| Feature | Our COASY NGS Test | Closest Alternative (Whole Exome Sequencing) |
|---|---|---|
| Precision | Targeted coverage > 99.9% of COASY coding exons ±10 bp | Broad but may miss splice-site variants, lower depth |
| Methodology | NGS with Sanger confirmation of pathogenic variants | NGS with variant filtering, high incidental findings rate |
| Turnaround Time | 3–4 Weeks | 6–12 Weeks |
| Clinical Actionability | Immediate integration with NBIA6 clinical pathway | Requires additional bioinformatics interpretative steps |
| Cost (UAE) | 2800 AED | 6000–8000 AED |
Clinical Insight & Safety Protocol – Dr. Prabhakar Reddy, Consultant Neurologist (DHA: 61713011)
“A positive COASY mutation does not operate in isolation; I strongly advocate correlating any genetic finding with the patient’s full clinical picture, brain MRI (T2* GRE/hypointensity in globus pallidus), and neurological examination. My team is available to discuss how this result fits into the broader diagnostic and management plan, remembering that a negative result does not exclude other forms of neurodegeneration.”
“Always maintain prescribed neuroprotective and symptomatic therapies—abrupt discontinuation can provoke severe spasticity or status dystonicus. This test is a guidepost, not a replacement for ongoing neurological care.”
“In paediatric or young adult patients, a confirmed diagnosis enables early enrolment in disease‑specific registries and future clinical trial screening; therefore timely testing is of the essence.”
⚠ Medication Safety Notice
Do not discontinue prescribed medication without consulting your doctor. Abrupt withdrawal of antispasticity agents (e.g., baclofen) or dopamine‑blocking drugs can lead to life‑threatening dystonic storms or neuroleptic malignant syndrome.
Exclusion Criteria & Emergency Red Flags
- Exclusion from home collection: Active febrile illness, haemodynamic instability, or inability to provide informed consent (legal guardian required for minors per UAE CDS Law 2026).
- Sample rejection risk: Blood collected within 90 days after whole blood transfusion or stem cell infusion (donor DNA may confound results).
- ER Red Flags – seek immediate care if you experience: Sudden worsening of dystonia, new‑onset seizures, respiratory compromise, or altered consciousness. These may indicate metabolic crisis or intracranial pressure changes.
Patient FAQ & Clinical Guidance
Q: Why is the COASY gene test ordered for brain iron accumulation?
This NGS test detects COASY pathogenic variants to confirm Neurodegeneration with Brain Iron Accumulation Type 6 in patients with progressive dystonia and characteristic MRI findings. It differentiates NBIA6 from other forms like PKAN or PLA2G6‑associated neurodegeneration, guiding precise management and family genetic counselling.
س: لماذا يتم طلب اختبار الجين COASY عند تراكم الحديد في الدماغ؟
يقوم اختبار التسلسل الجيني هذا بالكشف عن الطفرات الممرضة في جين COASY لتأكيد مرض التنكس العصبي مع تراكم الحديد في الدماغ من النوع 6 لدى المرضى الذين يعانون من خلل التوتر التدريجي ونتائج الرنين المغناطيسي المميزة.
Q: How do I prepare for the COASY DNA test and what sample is needed?
You need a clinical history review, a genetic counselling session to draw a pedigree chart, and a simple blood draw or FTA card spot. No fasting is required; continue prescribed medications unless your neurologist advises otherwise. Our mobile phlebotomist collects 2–3 ml whole blood in EDTA tube, or you may submit extracted DNA, all handled via cold‑chain.
س: كيف أستعد لاختبار الحمض النووي COASY وما هي العينة المطلوبة؟
تحتاج إلى جلسة استشارة جينية لرسم شجرة العائلة وسحب عينة دم بسيطة أو بطاقة FTA، دون الحاجة للصيام، مع الاستمرار في تناول أدويتك الموصوفة ما لم يوجه الطبيب بغير ذلك.
Q: What does a negative COASY test result mean and what are my next steps?
A negative report means no pathogenic COASY variant was identified, lowering NBIA6 probability but not ruling out other neurodegenerative disorders. Your neurologist may recommend broader NBIA panel testing, mitochondrial DNA studies, or repeat MRI with susceptibility‑weighted imaging to evaluate for other iron‑accumulating conditions.
س: ماذا تعني نتيجة اختبار COASY السلبية وما هي الخطوات التالية؟
تعني النتيجة السلبية عدم وجود طفرة ممرضة في جين COASY، مما يقلل احتمالية النوع 6، لكنه لا يستبعد الاضطرابات التنكسية الأخرى، وقد يوصي طبيبك بإجراء فحوصات أوسع أو تصوير إضافي.
Pre‑Test Information & Sample Logistics
- Required Documentation: Clinical history including age of onset, neurological exam findings, family history, and prior MRI reports. A formal genetic counselling session to draw a pedigree chart of family members affected by COASY‑associated neurodegeneration is mandatory.
- Acceptable Specimens: Whole Blood (EDTA), Extracted DNA (≥1 µg), or One drop of blood on FTA Card. All samples must be collected by DHA‑licensed personnel.
- Turnaround Time: 3 to 4 Weeks from receipt of adequate sample.
- Price: 2800 AED (including pre‑ and post‑test counselling support).
- Legal Compliance: This is performed in accordance with UAE Federal Decree‑Law No. 41 of 2024 (Art. 87), CDS Law 2026 provisions for minors, and UAE PDPL data privacy regulations. ISO 9001:2015 Certified (Cert: INT/EGQ/2509DA/3139).
DHA Licensed Facility: 9834453 | 24/7 WhatsApp Support & Booking: +971 54 548 8731
ISO 9001:2015 Certified Diagnostic Excellence – INT/EGQ/2509DA/3139
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