Test Price
2,800 AEDโ Home Collection Available
ARHGEF10 Gene Slowed Nerve Conduction Velocity, Autosomal Dominant Genetic Test in UAE | 2800 AED | DHA Licensed
Executive Summary & Core Metrics
Key Metrics
- Accuracy Guarantee: 99.9% Diagnostic Sensitivity via ISO 9001:2015 Accredited Processing (Cert: INT/EGQ/2509DA/3139).
- Premium Logistics: VIP Mobile Phlebotomy & Temperature-Controlled Cold-Chain Home Collection (Available daily from 8 AM to 11 PM).
- Clinical Guidance: Telephonic Post-Test Clinical Guidance for result interpretation with DHA-certified genetics expert.
- Insurance: Direct Billing Verification via WhatsApp +971 54 548 8731.
Our ARHGEF10 gene test provides definitive molecular diagnosis for autosomal dominant inherited neuropathy with slowed nerve conduction. Backed by ISO 9001:2015 accreditation and strict compliance with UAE data protection laws (Federal Decree-Law No. 45 of 2021 on Personal Data Protection), your genetic data remains secure and processed locally.
Test Overview & Methodology
This advanced genetic test uses Next-Generation Sequencing (NGS) on the Illumina NovaSeq X Plus platform to analyze the entire coding region and intronic boundaries of the ARHGEF10 gene. It detects single nucleotide variants, small insertions/deletions, and copy number variations that cause autosomal dominant slowed nerve conduction velocity neuropathy (Charcot-Marie-Tooth disease type 2).
| Feature | Our Test (Gold Standard) | Closest Alternative |
|---|---|---|
| Precision | 99.9% sensitivity via NGS | Sanger sequencing (~85% sensitivity, single gene) |
| Method | NGS (Illumina NovaSeq X Plus) with CNV calling | Capillary electrophoresis Sanger |
| Turnaround Time | 3 to 4 weeks | 6 to 8 weeks |
Physician Insight & Safety Protocols
โAs a DHA-licensed Consultant Medical Geneticist, I emphasize that the ARHGEF10 genetic test is a powerful diagnostic tool that must be interpreted in conjunction with a comprehensive clinical evaluation, nerve conduction studies, and a detailed three-generation family history. A positive result confirms the molecular etiology of slowed nerve conduction velocity; a negative result does not exclude other hereditary neuropathies. It is essential to maintain all current treatments and consult your physician before making any changes.โ
โ Lina Osama Zaki Quteineh, Consultant Medical Genetics, DHA Registration ID: 9294403
Medication & Safety Advisory
Do not discontinue any prescribed medication without consulting your treating physician. This genetic test is not a replacement for acute neurological assessment. Always follow the clinical judgment of your healthcare provider.
Exclusion Criteria & Emergency Red Flags
- Inability to provide informed consent or lack of legal guardian consent (mandatory for minors per Federal Decree-Law No. 4 of 2016 on Medical Liability).
- Sample collected in non-DNA-stabilizing tube, insufficient volume, or severe hemolysis.
- Acute neurological symptoms such as sudden bilateral weakness, vision loss, slurred speech, or seizure require immediate emergency careโdo not wait for this test.
Patient FAQ & Clinical Guidance
1. What is the ARHGEF10 gene test?
This NGS test identifies pathogenic variants in the ARHGEF10 gene responsible for autosomal dominant slowed nerve conduction velocity (Charcot-Marie-Tooth disease type 2).
It examines the DNA sequence to detect mutations causing hereditary neuropathy with slowed conduction. Results aid in accurate diagnosis, family risk assessment, and management planning.
2. How is the specimen collected?
A simple blood draw (5 mL EDTA tube) or a dried blood spot on FTA card is collected by a certified phlebotomist during our home visit.
Our VIP Mobile Phlebotomy team follows strict cold-chain protocols to preserve DNA integrity, available daily from 8 AM to 11 PM. Alternatively, you may visit our DHA-licensed facility.
3. Is pre-test genetic counselling required?
Yes, a mandatory genetic counselling session and pedigree chart documentation are required before sample collection per DHA regulations.
This ensures informed consent, a detailed three-generation family history, and appropriate test selection. Our team arranges a telehealth counselling session at your convenience.
UAE Regulatory & Data Privacy Adherence
This service fully complies with:
- Federal Decree-Law No. 45 of 2021 on Personal Data Protection (PDPL) โ ensuring your genetic data is processed locally, with anonymized storage and strict access controls.
- Federal Law No. 2 of 2019 Concerning the Use of Information and Communication Technology in Health Fields โ governing secure electronic health records and telehealth interactions.
- Federal Decree-Law No. 4 of 2016 on Medical Liability โ including provisions for informed consent and patient safety in diagnostic procedures.
Your data remains confidential and is never shared without your explicit consent. The laboratory is ISO 9001:2015 accredited (Cert: INT/EGQ/2509DA/3139) and licensed by the Dubai Health Authority (DHA) under facility license no. 1143.
Clinical & Logistical Metadata
| Test Name | ARHGEF10 Gene Slowed Nerve Conduction Velocity, Autosomal Dominant Genetic Test (NGS) |
| Price (AED) | 2,800 |
| Turnaround Time | 3 to 4 weeks |
| Sample Type / Matrix | Peripheral whole blood (5 mL EDTA), extracted DNA, or dried blood spot on FTA card |
| Methodology Used | Next-Generation Sequencing (NGS) โ Illumina NovaSeq X Plus with CNV detection |
| ICD-10-CM Code | G60.0 (Hereditary motor and sensory neuropathy) |
| LOINC Code | 51966-3 (Genetic test for hereditary neuropathy) |
| DHA Facility License & Laboratory Address | Facility License: 1143 | Premises 105, Floor 1, Building 33, Dubai Healthcare City, Dubai, UAE โ DNA Labs UAE |
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