Test Price
2,800 AED✅ Home Collection Available
WNK1 Gene HSAN2A Genetic Test in UAE | AED 2800 | DHA Licensed
Executive Summary & Core Metrics
- Accuracy Guarantee: 99.9% Diagnostic Sensitivity via ISO 9001:2015 accredited processing.
- Premium Logistics: VIP Mobile Phlebotomy & Temperature-Controlled Cold-Chain Home Collection available daily from 8 AM to 11 PM.
- Clinical Guidance: Telephonic Post-Test Clinical Guidance for result interpretation.
- Insurance: Direct Billing Verification via WhatsApp +971 54 548 8731.
Test Overview & Methodology
The WNK1 Gene HSAN2A Genetic Test utilizes next-generation sequencing (NGS) to detect pathogenic variants in the WNK1 gene, associated with autosomal recessive hereditary sensory and autonomic neuropathy type IIA (HSAN2A). This test provides a definitive diagnosis for patients with progressive sensory loss, autonomic dysfunction, and a relevant family history. The assay identifies single nucleotide variants, small insertions/deletions, and copy number variations with 99.9% analytical sensitivity, enabling tailored clinical management and genetic counseling.
| Feature | Our WNK1 NGS Test | Closest Alternative |
|---|---|---|
| Precision | Full gene sequencing + CNV analysis, ACMG variant classification | PCR-based targeted mutation panel (limited variants) |
| Method | Next-Generation Sequencing (Illumina platform), GRCh38 alignment | Sanger sequencing of select exons |
| Turnaround Time | 3–4 weeks with telephonic clinical guidance | 4–6 weeks, often without genetic counseling support |
Physician Insight & Safety Protocols
“As a Consultant Medical Genetics, I understand the emotional journey of seeking a genetic diagnosis. This test is a pivotal step toward clarity, but results must be interpreted within the context of the complete clinical presentation and family pedigree. A negative result does not exclude all genetic causes, and ongoing specialist follow-up remains essential. I am available for telephonic clinical guidance after your report is available.”
— Lina Osama Zaki Quteineh, Consultant Medical Genetics, DHA Registration ID: 9294403
⚠ Medication Advisory
Do not discontinue or alter prescribed medications without consulting your treating physician. This test does not require medication changes unless specified by your doctor.
Exclusion Criteria & Emergency Red Flags
- Exclusion: Inability to provide informed consent (or guardian consent for minors), severe coagulopathy precluding safe phlebotomy, or lack of a healthcare professional for collection.
- Red Flags: Acute onset of severe pain, sudden sensory loss, falls, or autonomic crisis (severe blood pressure fluctuations, cardiac arrhythmia) – seek emergency medical care immediately. This test is not an emergency diagnostic tool.
Patient FAQ & Clinical Guidance
1. What conditions are diagnosed by the WNK1 Gene HSAN2A NGS test?
This test detects mutations causing hereditary sensory and autonomic neuropathy type IIA (HSAN2A), a progressive genetic disorder. It confirms the clinical diagnosis in patients presenting with loss of pain and temperature sensation, autonomic dysfunction (such as blood pressure instability), and a family history suggestive of autosomal recessive inheritance. The test also aids in carrier screening for at-risk relatives.
2. How should I prepare for the WNK1 genetic test, and is fasting required?
No fasting or special preparation is required; a simple whole blood sample (EDTA), extracted DNA, or a dried blood spot on an FTA card is sufficient. You will first attend a genetic counseling session to discuss the clinical history and draw a family pedigree. Samples can be collected at home by our ISO-certified phlebotomy team using temperature-controlled cold-chain logistics to preserve DNA integrity.
3. What does a positive result mean for my family and future health?
A positive result confirms HSAN2A, necessitating genetic counseling for family risk assessment and management planning. Because the condition is autosomal recessive, siblings have a 25% risk of being affected, and carrier parents can use this information for reproductive decisions. You will receive a detailed genetic report and a telephonic consultation with our clinical geneticist to interpret the findings and coordinate specialized neurological care.
UAE Regulatory & Data Privacy Adherence
This test is conducted in full compliance with Federal Decree-Law No. 45 of 2021 on Personal Data Protection (PDPL) and Federal Law No. 2 of 2019 Concerning the Use of Information and Communication Technology in Health Fields. Clinical safety and patient consent adhere to Federal Decree-Law No. 4 of 2016 on Medical Liability. Our facility holds ISO 9001:2015 certification (Cert: INT/EGQ/2509DA/3139) and DHA license no. 1143, ensuring the highest data security and clinical quality. Patient data is encrypted and stored in accordance with UAE standards.
Clinical & Logistical Metadata
| Test Name | WNK1 Gene HSAN2A Genetic Test (Next-Generation Sequencing) |
| Price (AED) | 2,800 AED |
| Turnaround Time | 3–4 weeks (includes telephonic clinical guidance) |
| Sample Type / Matrix | Whole blood (EDTA), extracted DNA, or FTA card (blood spot) |
| Methodology Used | Next-Generation Sequencing (Illumina), CNV analysis, ACMG variant interpretation |
| ICD-10-CM Code | G60.8 |
| LOINC Code | 55989-0 |
| DHA Facility License & Laboratory Address | Facility License: 1143 | Premises 105, Floor 1, Building 33, Dubai Healthcare City, Dubai, UAE | DNA Labs UAE |
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