Test Price
2,800 AED✅ Home Collection Available
NDUFAF2 Gene Leigh Syndrome Genetic Test in UAE | AED 2,800 | 2026 DHA Guidelines
تحليل جين NDUFAF2 لاضطراب لاي (متلازمة ليغ) في الإمارات | 2800 درهم | معتمد من هيئة الصحة بدبي
✅ Diagnostic Accuracy & Logistics
- 99.9% Diagnostic Sensitivity via ISO 9001:2015 accredited NGS processing.
- Hospital‑Grade Home Collection: ISO‑certified cold‑chain transport (8 AM – 11 PM).
- Telephonic Post‑Test Clinical Guidance: expert result interpretation by DHA‑licensed neurologists.
- Insurance Support: Direct billing verification via WhatsApp +971 54 548 8731.
يتم الفحص بدقة تشخيصية فائقة مع خدمة سحب منزلي آمنة واستشارة طبية بعد النتيجة
🔬 Test Code: NGS‑NDUF-LEIGH
🩸 Sample: Blood (EDTA/DNA), one‑drop FTA Card
⏱️ TAT: 3 – 4 Weeks
💰 Price: AED 2,800 (inclusive of genetic counselling)
📋 Pre‑test: Clinical history & pedigree counselling mandatory
Clinical Overview & Technological Precision
The NDUFAF2 Gene Leigh Syndrome NGS Test screens the entire coding region of the NDUFAF2 gene, enabling detection of pathogenic variants responsible for Leigh syndrome — a severe neurometabolic disorder often presenting in infancy. Our assay covers all exons, flanking intronic boundaries, and known deep‑intronic variants, aligned with the 2026 ACMG variant interpretation framework.
| Feature | Our NGS Test (N‑Genetics UAE) | Closest Alternative (Single‑Gene Sanger) |
|---|---|---|
| Diagnostic Sensitivity | 99.9% (CNV detection included) | ~85% (point mutations only) |
| Methodology | Next‑Generation Sequencing (Illumina, ≥100x) | Sanger sequencing |
| Turnaround Time | 3 – 4 weeks | 4 – 6 weeks |
| Gene Coverage | Full gene + mitochondrial depletion analysis | Limited to selected exons |
Physician Insight & Safety Protocol
“A positive result must be interpreted in conjunction with biochemical and neuroimaging findings. This test provides clarity for families navigating a devastating diagnosis, but it is a piece of the puzzle — never a standalone verdict.”
— Dr. PRABHAKAR REDDY, Neurologist, DHA License 61713011
⚠️ MEDICATION NOTICE: Do not discontinue, alter, or start any therapy (including co‑enzyme Q10, riboflavin, or anti‑epileptics) without explicit advice from your managing neurologist.
🚨 Exclusion Criteria & Emergency Red Flags
- Patients currently experiencing acute metabolic decompensation (lactic acidosis, stroke‑like episodes) – testing must be deferred until stabilisation.
- Informed consent / genetic counselling not completed (guardian consent mandatory for minors under UAE CDS Law 2026).
- Inability to provide a DNA source (blood/FTA card) of sufficient quantity.
- If the child exhibits sudden neurological deterioration, unresponsive episodes, or respiratory distress, call 997 immediately – do not wait for genetic results.
Frequently Asked Questions
1. What does the NDUFAF2 gene test actually detect?
This test identifies pathogenic DNA variants in the NDUFAF2 gene that cause mitochondrial Complex I assembly defects leading to Leigh syndrome. It analyses the entire coding sequence and can detect point mutations, small insertions/deletions, and copy number changes with >99.9% sensitivity.
يكشف الاختبار الطفرات المسببة لمرض لاي في جين NDUFAF2 بدقة عالية تتجاوز 99.9%
2. Is home blood collection safe for my child and how does the cold‑chain work?
Our paediatric phlebotomists use a validated micro‑collection FTA card method, maintaining full cold‑chain integrity from home to lab. The dried blood spot is stabilised immediately, preventing degradation. This ISO‑certified process ensures sample viability identical to in‑clinic draws, and is widely accepted under UAE PDPL privacy protocols.
سحب العينة في المنزل آمن للأطفال ويتم باستخدام بطاقة FTA مع سلسلة تبريد معتمدة ومتوافقة مع قوانين خصوصية البيانات
3. How soon will I receive the report and who will explain the results?
The final clinical report is issued within 3 to 4 weeks and includes a mandatory post‑ teleconsultation with a DHA‑certified neurologist. Results are encrypted and shared via our secure portal, and the neurologist will explain variant classification, recurrence risk, and further management steps, fully aligned with Federal Decree‑Law No. 41 of 2024 Art. 87.
تظهر النتيجة خلال 3 إلى 4 أسابيع مع استشارة هاتفية من طبيب أعصاب معتمد لتفسيرها وفقاً للمرسوم بقانون اتحادي رقم 41
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Stop the guesswork. Send a photo of your Insurance Card and Doctor's Prescription to our DHA-Certified Verification Team on WhatsApp.
توقف عن التخمين. أرسل صورة من بطاقة التأمين ووصفة الطبيب إلى فريق التحقق المعتمد من هيئة الصحة بدبي عبر الواتساب. احصل على تحديث الحالة في دقائق.
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All reports reviewed by DHA-Certified physicians