Test Price
2,800 AED✅ Home Collection Available
NDUFAF2 Gene Leigh Syndrome Genetic Test in UAE | AED 2,800 | DHA-Licensed Facility
Executive Summary & Core Metrics
✅ Diagnostic Accuracy & Logistics
- 99.9% Diagnostic Sensitivity via ISO 9001:2015 accredited NGS processing.
- VIP Mobile Phlebotomy & Temperature-Controlled Cold-Chain Home Collection available daily from 8 AM to 11 PM.
- Telephonic Post-Test Clinical Guidance: expert result interpretation by DHA-licensed consultant medical geneticist.
- Insurance Support: Direct billing verification via WhatsApp +971 54 548 8731.
🔬 Test Code: NGS‑NDUF-LEIGH
🩸 Sample: Blood (EDTA) or FTA Card
⏱️ TAT: 3 – 4 Weeks
💰 Price: AED 2,800 (inclusive of genetic counselling)
📋 Pre-test: Clinical history & pedigree counselling mandatory
Test Overview & Methodology
The NDUFAF2 Gene Leigh Syndrome NGS Test screens the entire coding region of the NDUFAF2 gene, enabling detection of pathogenic variants responsible for Leigh syndrome — a severe neurometabolic disorder often presenting in infancy. Our assay covers all exons, flanking intronic boundaries, and known deep‑intronic variants, aligned with the latest ACMG variant interpretation framework.
| Feature | Our NGS Test (DNA Labs UAE) | Closest Alternative (Single‑Gene Sanger) |
|---|---|---|
| Diagnostic Sensitivity | 99.9% (CNV detection included) | ~85% (point mutations only) |
| Methodology | Next‑Generation Sequencing (Illumina, ≥100x) | Sanger sequencing |
| Turnaround Time | 3 – 4 weeks | 4 – 6 weeks |
| Gene Coverage | Full gene + mitochondrial depletion analysis | Limited to selected exons |
Physician Insight & Safety Protocols
“A positive result must be interpreted within the full clinical context, including biochemical and neuroimaging findings. This test provides crucial clarity for families confronting this devastating diagnosis, but it is one piece of the puzzle — never a standalone verdict. Pre‑ and post‑test genetic counselling is mandatory for all patients.”
— Lina Osama Zaki Quteineh, Consultant Medical Genetics, DHA Registration ID: 9294403
Advisory Medication Notice
⚠️ Do not discontinue, alter, or start any therapy (including co‑enzyme Q10, riboflavin, or anti‑epileptics) without explicit advice from your managing neurologist.
Exclusion Criteria & Emergency Red Flags
- Patients currently experiencing acute metabolic decompensation (lactic acidosis, stroke‑like episodes) – testing must be deferred until stabilisation.
- Informed consent / genetic counselling not completed (guardian consent mandatory for minors under UAE law).
- Inability to provide a DNA source (blood/FTA card) of sufficient quantity.
- If the child exhibits sudden neurological deterioration, unresponsive episodes, or respiratory distress, call 997 immediately – do not wait for genetic results.
Patient FAQ & Clinical Guidance
1. What does the NDUFAF2 gene test actually detect?
This test identifies pathogenic DNA variants in the NDUFAF2 gene that cause mitochondrial Complex I assembly defects leading to Leigh syndrome. It analyses the entire coding sequence and can detect point mutations, small insertions/deletions, and copy number changes with >99.9% sensitivity.
2. Is home blood collection safe for my child and how does the cold‑chain work?
Our paediatric phlebotomists use a validated micro‑collection FTA card method, maintaining full cold‑chain integrity from home to lab. The dried blood spot is stabilised immediately, preventing degradation. This ISO‑certified process ensures sample viability identical to in‑clinic draws, and is widely accepted under UAE PDPL privacy protocols.
3. How soon will I receive the report and who will explain the results?
The final clinical report is issued within 3 to 4 weeks and includes a mandatory post‑test teleconsultation with a DHA‑certified consultant medical geneticist. Results are encrypted and shared via our secure portal, and the geneticist will explain variant classification, recurrence risk, and further management steps.
UAE Regulatory & Data Privacy Adherence
This test is performed in full compliance with Federal Decree‑Law No. 45 of 2021 on Personal Data Protection (PDPL) and Federal Law No. 2 of 2019 Concerning the Use of Information and Communication Technology in Health Fields. Patient consent and medical liability are governed by Federal Decree‑Law No. 4 of 2016 on Medical Liability. DNA Labs UAE holds DHA Facility License No. 1143 and ISO 9001:2015 certification, ensuring the highest standards of privacy, safety, and clinical accuracy.
Clinical & Logistical Metadata
| Test Name | NDUFAF2 Gene Leigh Syndrome Genetic Test |
| Price (AED) | 2,800 |
| Turnaround Time | 3 – 4 weeks |
| Sample Type / Matrix | Whole blood (EDTA) or FTA Card |
| Methodology Used | Next‑Generation Sequencing (NGS) |
| ICD‑10‑CM Code | G31.82 (Leigh syndrome) |
| LOINC Code | 95213‑9 (Gene sequencing) |
| DHA Facility License & Address | License No. 1143 — Premises 105, Floor 1, Building 33, Dubai Healthcare City, Dubai, UAE |
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All reports reviewed by DHA-Certified physicians