Test Price
2,800 AED✅ Home Collection Available
JPH3 Gene Huntington Disease‑Like 2 (HDL2) Genetic Test in UAE | AED 2,800
Executive Summary & Core Metrics
This molecular test uses Next‑Generation Sequencing (NGS) combined with repeat‑primed PCR to detect pathogenic CTG/CAG expansions in the JPH3 gene, confirming Huntington disease‑like 2 (HDL2) with a diagnostic sensitivity of 99.9%. The test is performed in an ISO 9001:2015 accredited laboratory and includes a pre‑test genetic counselling session and a post‑report tele‑consultation with a DHA‑licensed clinical geneticist.
- ✓ Accuracy Guarantee: 99.9% diagnostic sensitivity via ISO‑accredited processing.
- ✓ Premium Logistics: VIP mobile phlebotomy & temperature‑controlled cold‑chain home collection, available daily 8 AM – 11 PM.
- ✓ Clinical Guidance: Telephonic post‑test interpretation by a DHA‑licensed consultant medical geneticist.
- ✓ Insurance: Direct billing verification via WhatsApp +971 54 548 8731.
Test Overview & Methodology
The JPH3 Huntington disease‑like 2 (HDL2) genetic test is ordered when Huntington disease (HTT gene) testing is negative but the patient presents with chorea, cognitive decline, and a compatible family history. The assay uses NGS for initial scanning followed by confirmatory repeat‑primed PCR to precisely size the CTG repeat tract in the JPH3 gene with ±1‑repeat accuracy. This dual‑method approach eliminates false negatives from allele dropout and detects somatic mosaicism.
| Feature | Our Test (NGS + Repeat‑Primed PCR) | Closest Alternative (Standard Fragment Analysis) |
|---|---|---|
| Precision | Allele‑specific sizing with ±1‑repeat accuracy | ±2–3 repeat deviation, may miss mosaicism |
| Method | Next‑Generation Sequencing + confirmatory RP‑PCR | Fragment‑length analysis only |
| Turnaround | 3–4 weeks | 4–6 weeks |
Physician Insight & Safety Protocols
“A positive JPH3 expansion result must always be correlated with the complete clinical picture—isolated genetic findings do not equate to a disease diagnosis. Predictive testing in asymptomatic adults requires a structured genetic counselling framework, and testing of minors is strictly prohibited under UAE law. Please consult a movement disorder neurologist or clinical geneticist before acting on any report.”
— Lina Osama Zaki Quteineh, Consultant Medical Genetics, DHA Registration ID: 9294403
Medication Advisory
⚠️ Do not discontinue any prescribed medication (e.g., antidepressants, neuroleptics, antiepileptics) without consulting your treating physician. Abrupt cessation may precipitate severe withdrawal or exacerbation of psychiatric symptoms.
Exclusion Criteria & Emergency Red Flags
- Do not undergo this test if you are currently experiencing acute suicidal ideation or severe psychosis — stabilise first.
- Not indicated for minors (below 18 years) per Federal Decree‑Law No. 4 of 2016 on Medical Liability.
- If you develop new‑onset seizures, unexplained falls, or swallowing difficulties after sample collection, seek emergency medical care immediately.
- Genetic counselling is mandatory before sample collection; we provide a DHA‑aligned tele‑counselling session pre‑test.
Patient FAQ & Clinical Guidance
1. What does the JPH3 HDL2 test detect, and why is it ordered?
This test identifies the CTG repeat expansion in the JPH3 gene that causes Huntington disease‑like 2. It is ordered when Huntington disease (HTT) genetic testing is negative but the patient presents with chorea, cognitive decline, and a family history suggestive of autosomal dominant inheritance.
2. How is the sample collected with the home service, and is it safe?
A DHA‑licensed phlebotomist visits your home (8 AM – 11 PM) using a temperature‑controlled transport kit. The whole‑blood (EDTA) or FTA card sample is immediately stabilised to preserve DNA integrity, maintaining diagnostic accuracy even in UAE summer heat.
3. Will my insurance cover this, and how do I confirm?
Coverage depends on your individual policy. We provide direct billing verification via WhatsApp at +971 54 548 8731, and we will check your insurer’s pre‑authorisation code before scheduling the collection. Most major UAE networks approve neurogenetic investigations.
4. Is pre‑test genetic counselling mandatory?
Yes, UAE law requires genetic counselling before any predictive genetic test. Our service includes a DHA‑aligned tele‑counselling session to discuss benefits, limitations, and potential psychological impact. Written informed consent is obtained before sample collection.
UAE Regulatory & Data Privacy Adherence
DNA Labs UAE operates under DHA Facility License No. 1143 (Premises 105, Floor 1, Building 33, Dubai Healthcare City). All genetic testing and patient data handling comply with:
- Federal Decree‑Law No. 45 of 2021 on Personal Data Protection (PDPL).
- Federal Law No. 2 of 2019 Concerning the Use of Information and Communication Technology in Health Fields.
- Federal Decree‑Law No. 4 of 2016 on Medical Liability for clinical safety and consent.
Your genetic data is encrypted, stored securely, and never shared without explicit consent. We adhere to international standards including ISO 27001 for information security.
Clinical & Logistical Metadata
| Test Name | JPH3 Gene Huntington Disease‑Like 2 (HDL2) Genetic Test |
| Price (AED) | 2,800 |
| Turnaround Time | 3–4 weeks |
| Sample Type / Matrix | Whole Blood (EDTA) or FTA Card — VIP Mobile Phlebotomy & Temperature-Controlled Cold-Chain Home Collection |
| Methodology Used | Next‑Generation Sequencing (NGS) + Repeat‑Primed PCR confirmatory assay |
| ICD-10-CM Code | G10 |
| LOINC Code | 101452-2 |
| DHA Facility License & Address | License No. 1143 — Premises 105, Floor 1, Building 33, Dubai Healthcare City, Dubai, UAE |
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