Test Price
2,800 AED✅ Home Collection Available
GLRB Gene Hyperekplexia Genetic Test in UAE | 2800 AED | DHA Licensed
Executive Summary & Core Metrics
- Diagnostic Accuracy: 99.9% sensitivity for coding region variants via ISO 9001:2015 accredited processing at DNA Labs UAE.
- Premium Logistics: VIP Mobile Phlebotomy and temperature-controlled cold-chain home collection available daily from 8 AM to 11 PM for peripheral blood, extracted DNA, or FTA card samples.
- Clinical Guidance: Post-test telephonic consultation with a certified genetic counselor to review results and discuss clinical implications.
- Insurance & Pricing: Direct billing verification available via WhatsApp at +971 54 548 8731. Total cost: 2800 AED (no hidden fees).
Test Overview & Methodology
The GLRB gene hyperekplexia NGS test sequences the glycine receptor beta subunit gene to identify pathogenic variants associated with hereditary hyperekplexia (startle disease). This rare neurological disorder presents with neonatal hypertonia, exaggerated startle reflexes, and potentially life-threatening apnea. Early molecular diagnosis guides treatment and genetic counseling.
Our method uses next-generation sequencing to achieve full coverage of all coding exons and splice junctions, enabling detection of single nucleotide variants, insertions, and deletions with high confidence.
| Feature | Our GLRB NGS Test | Sanger Sequencing (Alternative) |
|---|---|---|
| Methodology | Next-Generation Sequencing (NGS) – full gene coverage | Single‑variant or specific exon analysis |
| Diagnostic Sensitivity | 99.9% for coding variants | ~99% for targeted region |
| Turnaround Time | 3 – 4 Weeks | 4 – 6 Weeks |
| Sample Type | Blood, Extracted DNA, or One drop Blood on FTA Card | Blood only |
| Price | 2800 AED | Variable, often higher |
Physician Insight & Safety Protocols
“As a Consultant Medical Genetics, I recognize the precision this NGS test offers for diagnosing hyperekplexia. Accurate variant identification in the GLRB gene is crucial for guiding management and family counseling. However, genetic results must always be interpreted alongside clinical history and neurological evaluation. I recommend pre- and post-test genetic counseling to ensure informed decision-making.”
— Lina Osama Zaki Quteineh, Consultant Medical Genetics | DHA Registration ID: 9294403
Safety Advisory
Do not discontinue or modify any prescribed medication without consulting your primary neurologist. This genetic test is elective; it does not replace urgent care for acute neurological symptoms.
Exclusion Criteria & Emergency Red Flags
- Exclusion: Patients in acute neurological crisis (status epilepticus, uncontrolled seizures) cannot undergo home collection; emergency hospital referral is mandatory.
- Exclusion: Sedated or unresponsive individuals, and minors without legal guardian consent, are not eligible for this elective genetic test.
- Red Flag: Sudden onset of extreme muscle stiffness with breathing difficulty or loss of consciousness after a startle – seek immediate emergency care.
- Red Flag: Infants displaying apnea or prolonged cyanosis after startle require urgent neonatal ICU evaluation.
Patient FAQ & Clinical Guidance
1. What is the GLRB gene hyperekplexia test and why is it performed?
The GLRB NGS test sequences the glycine receptor beta subunit gene to diagnose hereditary hyperekplexia, a rare startle disorder causing stiffness and apnea. The test helps confirm a clinical suspicion and guides appropriate therapy and genetic counseling for affected individuals and families.
2. How is the sample collected and what is the turnaround time?
A simple blood draw, extracted DNA, or an FTA card sample is collected at home by a DHA-licensed phlebotomist. Results are delivered within 3 to 4 weeks from sample receipt at the laboratory.
3. Is genetic counseling required before or after the test?
Yes, pre-test counseling with a certified genetic counselor is mandatory to interpret family history, discuss test benefits and limitations, and obtain informed consent. Post-test counseling is recommended to understand results and their implications for clinical care and family planning.
UAE Regulatory & Data Privacy Adherence
This service strictly adheres to Federal Decree-Law No. 45 of 2021 on Personal Data Protection (PDPL) and Federal Law No. 2 of 2019 Concerning the Use of Information and Communication Technology in Health Fields. Clinical safety and patient consent follow Federal Decree-Law No. 4 of 2016 on Medical Liability. DNA Labs UAE operates under DHA Facility License Number 1143 and is ISO 9001:2015 certified (Cert: INT/EGQ/2509DA/3139). All specimen collection staff are DHA-licensed and adhere to stringent cold-chain and infection control protocols.
Clinical & Logistical Metadata
| Test Name | GLRB Gene Hyperekplexia Genetic Test |
| Price (AED) | 2,800 AED |
| Turnaround Time | 3 – 4 Weeks |
| Sample Type / Matrix | Peripheral whole blood (3-5 mL EDTA), extracted DNA (1 µg), or dried blood spot on FTA card |
| Methodology Used | Next‑Generation Sequencing (NGS) – full gene coding region and splice sites |
| ICD-10-CM Code | G25.89, Z14.8, E72.8 |
| LOINC Code | 94480-2 |
| DHA Facility License & Laboratory Address | DHA License: 1143 | Premises 105, Floor 1, Building 33, Dubai Healthcare City, Dubai, UAE |
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