Test Price
2,800 AED✅ Home Collection Available
SLC6A2 Gene Orthostatic Intolerance Genetic Test in Dubai
Executive Summary & Core Metrics
- Accuracy Guarantee: >99.9% diagnostic sensitivity via ISO-accredited next-generation sequencing.
- Premium Logistics: VIP mobile phlebotomy and temperature-controlled cold-chain home collection available daily 8 AM – 11 PM.
- Clinical Guidance: Telephonic post-test counselling with a consultant medical geneticist.
- Insurance: Direct billing verification via WhatsApp +971 54 548 8731.
- Price: 2,800 AED – all-inclusive with genetic counselling.
Test Overview & Methodology
The SLC6A2 gene orthostatic intolerance genetic test is a targeted molecular assay that sequences the entire coding region and splice‑site boundaries of the norepinephrine transporter gene. Pathogenic variants in SLC6A2 are linked to impaired synaptic norepinephrine reuptake, autonomic dysregulation, and clinical syndromes such as postural orthostatic tachycardia syndrome (POTS) and neurogenic orthostatic hypotension. This NGS‑based test provides definitive genotype‑phenotype correlation, enabling precise, personalised management for patients with suspected hereditary autonomic dysfunction in the UAE.
| Feature | DNA Labs UAE | Closest Alternative |
|---|---|---|
| Methodology | NGS (Next‑Generation Sequencing) | Sanger Sequencing (single‑gene) |
| Gene Coverage | Full coding region + splice sites | Selected exons only |
| Analytical Sensitivity | >99.9% | ~98% |
| Turnaround Time | 3–4 weeks | 6–8 weeks |
| Accreditation | ISO 9001:2015 | Variable |
Physician Insight & Safety Protocols
“A pathogenic SLC6A2 variant can explain debilitating orthostatic symptoms and directly guide targeted pharmacotherapy, yet results must always be interpreted alongside autonomic function testing and clinical history. Comprehensive pre‑test genetic counselling is essential to ensure informed decision‑making and accurate family pedigree analysis.”
— Lina Osama Zaki Quteineh, Consultant Medical Genetics, DHA Registration ID: 9294403
Medication Advisory & Emergency Red Flags
Do not discontinue or adjust prescribed medications such as beta‑blockers, midodrine, fludrocortisone, or vasoactive agents without direct consultation with your treating physician. Abrupt withdrawal may precipitate severe rebound hypertension, syncope, or cardiac instability.
- Not suitable for: Individuals with acute haemodynamic instability, active febrile illness, or uncorrected coagulopathy when a venipuncture sample is required.
- Seek emergency care if you experience: Chest pain, severe shortness of breath, loss of consciousness with injury, sudden confusion, or unrelenting palpitations.
- Sample collection may be deferred if the patient has an uncontrolled infection or is currently hospitalised.
- Mandatory genetic counselling prior to testing ensures informed consent, risk comprehension, and proper documentation of family history.
Patient FAQ & Clinical Guidance
1. What does the SLC6A2 gene test detect?
This targeted NGS test analyses the full coding sequence and splice junctions of the SLC6A2 gene to identify pathogenic variants that disrupt norepinephrine transporter function. Such mutations are associated with orthostatic intolerance, POTS, and autonomic nervous system dysfunction.
2. How is the sample collected for this genetic test?
Sample collection is performed via a standard venipuncture (whole blood) or a non‑invasive buccal swab. A certified phlebotomist can collect the specimen at your home between 8 AM and 11 PM through our VIP mobile phlebotomy service. All samples are transported under temperature‑controlled cold‑chain conditions.
3. Who should consider the SLC6A2 genetic evaluation?
Individuals experiencing persistent lightheadedness, palpitations, near‑syncope, or recurrent fainting upon standing — particularly those with a family history of orthostatic intolerance or POTS — should discuss this test with a genetic specialist. Early molecular diagnosis can guide lifestyle adjustments and pharmacological therapy.
4. What is the turnaround time for results?
Results are typically available within 3 to 4 weeks from sample receipt at the laboratory. A telephonic post‑test consultation with our consultant medical geneticist is scheduled to explain the findings and their clinical implications.
5. Is genetic counselling included in the test price?
Yes. The price of 2,800 AED includes mandatory pre‑test genetic counselling to discuss the purpose, benefits, risks, and possible outcomes of testing, as well as post‑test interpretation and guidance. This ensures compliance with UAE Federal Decree‑Law No. 4 of 2016 on Medical Liability.
UAE Regulatory & Data Privacy Adherence
Data Protection & Health Information Governance
All genetic data processing and storage at DNA Labs UAE strictly complies with Federal Decree‑Law No. 45 of 2021 on Personal Data Protection (PDPL) and Federal Law No. 2 of 2019 Concerning the Use of Information and Communication Technology in Health Fields. Patient genomic information is encrypted, access‑controlled, and never shared with third parties without explicit written consent.
Clinical Safety & Consent Framework
All testing procedures and patient consent protocols are governed by Federal Decree‑Law No. 4 of 2016 on Medical Liability, ensuring that every individual receives comprehensive pre‑test counselling and provides written informed consent prior to specimen collection.
Facility Accreditation: DHA Facility License No. 1143 | ISO 9001:2015 Certified (Cert: INT/EGQ/2509DA/3139)
Clinical & Logistical Metadata
| Test Name | SLC6A2 Gene Orthostatic Intolerance Genetic Test (NGS) |
| Price (AED) | 2,800 |
| Turnaround Time | 3–4 weeks |
| Sample Type / Matrix | Whole blood (EDTA tube) or buccal swab |
| Methodology Used | Next‑Generation Sequencing (NGS) – full coding region + splice sites |
| ICD‑10‑CM Code | I95.1 (Orthostatic hypotension), G90.9 (Autonomic nervous system disorder, unspecified) |
| LOINC Code | 81321‑4 (Norepinephrine transporter gene [SLC6A2] targeted mutation analysis in Blood or Tissue by Sequencing) |
| DHA Facility License & Address | License No. 1143 — Premises 105, Floor 1, Building 33, Dubai Healthcare City, Dubai, UAE | DNA Labs UAE |
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