Test Price
2,800 AED✅ Home Collection Available
OGDH Gene Alpha-Ketoglutarate Dehydrogenase Deficiency Genetic Test in UAE | 2800 AED | DHA Licensed
Executive Summary & Core Metrics
Core Metrics & Service Guarantees
- ✓ Accuracy Guarantee: 99.9% diagnostic sensitivity achieved via ISO‑certified processing and AI‑validated variant databases.
- ✓ Premium Logistics: VIP Mobile Phlebotomy with temperature-controlled cold-chain home collection available daily from 8 AM to 11 PM across all Emirates.
- ✓ Clinical Guidance: Complimentary telephonic post-test result interpretation session with a DHA-licensed genetic counsellor.
- ✓ Insurance: Direct billing verification available – send your insurance card to WhatsApp +971 54 548 8731 for instant pre-approval.
Test Overview & Methodology
This Next‑Generation Sequencing (NGS) test comprehensively analyses the entire coding region of the OGDH gene to detect single‑nucleotide variants, small insertions/deletions, and copy‑number changes responsible for alpha‑ketoglutarate dehydrogenase deficiency — a severe, often paediatric‑onset inborn error of the Krebs cycle. Powered by AI‑curated genomic reference databases, the assay delivers definitive molecular answers for diagnostic confirmation, carrier screening, and family risk assessment.
| Feature | Our Test (DNA Labs UAE) | Closest Alternative (Sanger Sequencing) |
|---|---|---|
| Precision | 99.9% sensitivity, 1000× average depth, AI‑powered variant calling | ~95% sensitivity for coding variants, no CNV detection |
| Methodology | NGS (Next‑Generation Sequencing) – Illumina NovaSeq™ X Plus platform | Bidirectional Sanger sequencing, limited to known hotspots |
| Turnaround Time | 3 to 4 weeks from sample receipt | 6 to 8 weeks |
Physician Insight & Safety Protocols
“As a DHA‑licensed consultant in medical genetics, I emphasise that while this NGS panel provides a high‑confidence molecular diagnosis, it must be correlated with clinical phenotype, biochemical markers, and family history. No medication or metabolic formula should ever be adjusted without direct consultation with your treating physician.”
— Lina Osama Zaki Quteineh, Consultant Medical Genetics, DHA Registration ID: 9294403
Safety Advisory & Pre-Test Requirements
Pre-Test Genetic Counselling
All patients must undergo a mandatory genetic counselling session prior to sample collection. This session covers the implications of test results, the possibility of incidental findings, and the necessity of informed consent. Consent documentation must be signed and archived in compliance with Federal Decree-Law No. 4 of 2016 on Medical Liability.
Patient Exclusion Criteria & Red Flags
- Transient Contraindication: Whole blood collected within 2 weeks of a packed red cell transfusion or in recipients of allogeneic haematopoietic stem cell transplant; donor DNA may confound the result.
- Not for Acute Crisis: This test is an elective diagnostic tool, not a replacement for emergency biochemical evaluation. If the patient develops acute lethargy, vomiting, seizures, or loss of consciousness, proceed directly to the nearest Emergency Department.
- Minors: Testing of individuals under 18 years requires written consent from a legal guardian, in strict adherence to Federal Decree-Law No. 4 of 2016.
Patient FAQ & Clinical Guidance
1. What is the OGDH gene test and who should consider it?
The OGDH gene test is a Next‑Generation Sequencing analysis that detects pathogenic mutations causing alpha‑ketoglutarate dehydrogenase deficiency, a neurodegenerative metabolic disorder. It is indicated for individuals with unexplained hypotonia, seizures, developmental delay, or a confirmed family history of metabolic disorders.
2. How accurate is this NGS test and what is the turnaround time?
Our ISO‑accredited NGS platform achieves 99.9% diagnostic sensitivity for single‑nucleotide variants and indels in the OGDH gene, with a reporting time of 3–4 weeks from sample arrival at the laboratory.
3. Is home collection available and how do I prepare?
Yes, we provide DHA‑licensed VIP Mobile Phlebotomy service across all seven Emirates with temperature-controlled cold-chain logistics. Preparation requires a prior genetic counselling session and a completed three‑generation pedigree chart to be submitted with the sample.
UAE Regulatory & Data Privacy Adherence
This laboratory assay is performed at DNA Labs UAE, a DHA-licensed facility (License No. 1143). All genetic data are handled in strict compliance with Federal Decree-Law No. 45 of 2021 on Personal Data Protection (PDPL) and Federal Law No. 2 of 2019 Concerning the Use of Information and Communication Technology in Health Fields. No genetic information is shared with third parties without explicit patient consent. The laboratory holds ISO 9001:2015 certification (Cert. INT/EGQ/2509DA/3139) and follows international standards for clinical genomic testing.
Clinical & Logistical Metadata
| Test Name | OGDH Gene Alpha-Ketoglutarate Dehydrogenase Deficiency Genetic Test (NGS) |
| Price (AED) | 2,800 AED |
| Turnaround Time | 3 to 4 weeks from sample receipt |
| Sample Type / Matrix | Peripheral whole blood (EDTA) – VIP Mobile Phlebotomy & Temperature-Controlled Cold-Chain Home Collection available |
| Methodology Used | Next-Generation Sequencing (NGS) – Illumina NovaSeq X Plus platform |
| ICD-10-CM Code | E88.8 (Other specified metabolic disorders), G31.8 (Other specified degenerative diseases of nervous system), Z13.79 (Encounter for screening for genetic and chromosomal anomalies) |
| LOINC Code | 79324-3 (Gene mutations found in Blood by Sequencing) |
| DHA Facility License & Address | DHA License No. 1143 | Premises 105, Floor 1, Building 33, Dubai Healthcare City, Dubai, UAE |
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ISMS 27001:2022
ISO Accredited
HIPAA
All reports reviewed by DHA-Certified physicians