Test Price
2,800 AED✅ Home Collection Available
Mucopolysaccharidosis Type II (MPS II) IDS Gene NGS Genetic Test in Dubai, UAE | 2800 AED | DHA Licensed Facility #1143
99.9% Diagnostic Sensitivity – ISO 9001:2015 Certified Accuracy
- Premium Logistics: VIP Mobile Phlebotomy & Temperature-Controlled Cold-Chain Home Collection (Available daily from 8 AM to 11 PM). Dried Blood Spot (FTA card) also accepted.
- Clinical Guidance: Complimentary pre-test genetic counselling session with a DHA-licensed genetic counselor; post-test telephonic result interpretation by a Consultant Medical Genetics.
- Insurance: Direct billing verification via WhatsApp at +971 54 548 8731.
Test Overview & Methodology
This Next‑Generation Sequencing (NGS) assay provides comprehensive analysis of the entire IDS gene, including coding exons and flanking intronic regions, to identify pathogenic variants responsible for Mucopolysaccharidosis Type II (Hunter syndrome). The test is designed for individuals with clinical suspicion of X‑linked lysosomal storage disease, positive family history, or carrier screening. It achieves 99.9% analytical sensitivity and is complemented by MLPA (Multiplex Ligation‑dependent Probe Amplification) for detection of large deletions or duplications.
| Feature | Our Test | Closest Alternative (Enzyme Assay) |
|---|---|---|
| Methodology | NGS (full IDS gene sequencing + MLPA for copy number variants) | Iduronate-2-sulfatase enzyme activity measurement (blood or fibroblasts) |
| Clinical Utility | Definitive molecular diagnosis; identifies specific variant; enables carrier testing, prenatal diagnosis, and preimplantation genetic diagnosis (PGD) | Biochemical confirmation only; cannot identify carriers or differentiate between variants |
| Turnaround Time | 3–4 weeks | 2–4 weeks |
| Sample Types | Whole blood (EDTA), extracted DNA, or one drop on FTA card | Whole blood (heparin) or cultured skin fibroblasts |
Physician Insight & Safety Protocols
“A positive IDS gene result confirms a diagnosis of Hunter syndrome (MPS II) with high accuracy. However, correlation with clinical presentation, biochemical markers (e.g., urinary GAGs), and enzyme activity remains essential for comprehensive management. I strongly recommend pre‑ and post‑test genetic counselling to help families understand the X‑linked inheritance pattern and to discuss reproductive options. Our team provides step‑by‑step guidance to ensure informed decision‑making.”
— Lina Osama Zaki Quteineh, Consultant Medical Genetics, DHA Registration ID: 9294403
⚠ Medication Warning & Clinical Advisory
Do not alter or discontinue any prescribed enzyme replacement therapy or supportive medications without consulting your treating physician. This genetic test is not a substitute for clinical management.
Exclusion Criteria & Emergency Red Flags
- Patients with acute respiratory distress, severe neuropsychiatric decline, or suspected metabolic decompensation must seek immediate emergency care – this test is not suitable for acute presentations.
- Prenatal diagnosis is only valid if the familial pathogenic variant has been previously identified in the family.
- Do not collect samples from individuals who have received hematopoietic stem cell transplantation or gene therapy; maternal cell contamination can affect chorionic villus sampling results.
Patient FAQ & Clinical Guidance
1. What does the IDS gene NGS test detect?
This test sequences the entire IDS gene to identify disease‑causing variants responsible for Mucopolysaccharidosis Type II (Hunter syndrome), an X‑linked recessive lysosomal storage disorder. It provides a definitive molecular diagnosis and is essential for carrier detection and reproductive planning.
2. Why is genetic counselling required before and after this test?
Pre‑test counselling includes a detailed pedigree analysis to assess inheritance risk and ensure you fully understand the implications for yourself and family members. Post‑test counselling helps interpret results within the context of clinical findings and provides guidance on management, surveillance, and family screening.
3. Can I use a dried blood spot (FTA card) for the MPS II test?
Yes, one drop of blood on an FTA card is accepted as a stable DNA source, eliminating the need for venipuncture. The sample is shipped via secure courier at room temperature. Alternatively, whole blood (EDTA) or extracted DNA can be used.
4. How long does it take to get results?
The turnaround time is 3–4 weeks from sample receipt. This includes sequencing, bioinformatics analysis, variant interpretation, and clinical reporting. Urgent cases may be expedited upon request.
UAE Regulatory & Data Privacy Adherence
Your Data and Rights Are Protected Under UAE Law
- Federal Decree-Law No. 45 of 2021 on Personal Data Protection (PDPL): All genetic data is processed with strict privacy controls, consent management, and data minimization principles.
- Federal Law No. 2 of 2019 Concerning the Use of Information and Communication Technology in Health Fields: Ensures secure electronic health records and telemedicine compliance.
- Federal Decree-Law No. 4 of 2016 on Medical Liability: Governs clinical testing safety, patient consent, and professional accountability.
- DNA Labs UAE is a DHA‑licensed facility (License #1143) operating under ISO 9001:2015 quality management standards.
Clinical & Logistical Metadata
| Test Name | Mucopolysaccharidosis Type II (MPS II) – IDS Gene Full Sequencing & MLPA |
| Price (AED) | 2,800 AED (All inclusive) |
| Turnaround Time | 3–4 weeks |
| Sample Type / Matrix | Whole blood (EDTA), extracted DNA, or dried blood spot (FTA card). VIP Mobile Phlebotomy & Temperature-Controlled Cold-Chain Home Collection available daily 8 AM – 11 PM. |
| Methodology Used | Next‑Generation Sequencing (NGS) – Illumina platform; MLPA for deletion/duplication analysis. Variant interpretation per ACMG guidelines. |
| ICD-10-CM Code | E76.1 (Mucopolysaccharidosis type II) |
| LOINC Code | 82850-2 (IDS gene full mutation analysis) |
| DHA Facility License & Laboratory Address | License #1143 | DNA Labs UAE, Premises 105, Floor 1, Building 33, Dubai Healthcare City, Dubai, UAE |
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