Test Price
2,800 AED✅ Home Collection Available
GPR161 Gene Pituitary Stalk Interruption Syndrome (GPR161-Related) Genetic Test in UAE | 2,800 AED
Executive Summary & Core Metrics
- Accuracy Guarantee: 99.9% Diagnostic Sensitivity via ISO 9001:2015 Accredited Processing.
- Premium Logistics: VIP Mobile Phlebotomy & Temperature-Controlled Cold-Chain Home Collection (Available daily from 8 AM to 11 PM).
- Clinical Guidance: Telephonic Post-Test Clinical Guidance in result interpretation by a DHA-licensed genetic counsellor.
- Insurance: Direct Billing Verification via WhatsApp +971 54 548 8731.
- Turnaround Time: 3–4 Weeks from sample receipt.
Test Overview & Methodology
The GPR161 gene is associated with pituitary stalk interruption syndrome (PSIS), a rare congenital disorder causing multiple pituitary hormone deficiencies. This Next-Generation Sequencing (NGS) test analyses the entire GPR161 coding region to detect pathogenic variants, guiding precise diagnosis and management.
| Feature | Our Test (GPR161 NGS) | Closest Alternative (Single-Gene Sequencing) |
|---|---|---|
| Precision | Full-coverage NGS with ≥99.9% analytical sensitivity | May miss deep-intronic or copy-number variants |
| Methodology | Illumina® NGS with bioinformatics confirmation | Conventional Sanger sequencing |
| Turnaround Time | 3–4 Weeks (complex variant review included) | Up to 6 weeks for single-gene analysis |
Physician Insight & Safety Protocols
“Interpretation of a positive GPR161 result requires multidisciplinary correlation with neuroimaging, dynamic hormonal assays, and clinical phenotype. This test facilitates tailored hormone replacement therapy and familial cascade screening, but does not supplant ongoing paediatric endocrinology surveillance.” – Lina Osama Zaki Quteineh (DHA Registration ID: 9294403), Consultant Medical Genetics.
Advisory: Medication Continuity
Never discontinue prescribed hormone therapy without consulting your treating physician. Genetic results support long-term management strategies; abrupt cessation of pituitary hormone replacement can precipitate life-threatening adrenal crisis or metabolic decompensation.
Exclusion Criteria & Emergency Red Flags
- Exclusion: Severe coagulopathy or active infection at the time of blood draw; inability to provide informed consent (legal guardian consent required for minors).
- Red Flags – Seek Immediate Care: Signs of adrenal crisis (profound weakness, vomiting, hypotension, altered consciousness) in a child with suspected pituitary deficiency. This test does not replace urgent endocrine evaluation.
Patient FAQ & Clinical Guidance
1. What is GPR161 pituitary stalk interruption syndrome?
GPR161 pituitary stalk interruption syndrome is a rare genetic disorder that disrupts pituitary gland development, leading to multiple hormone deficiencies and growth failure. Caused by loss-of-function variants in the GPR161 gene, it typically presents in infancy with hypoglycaemia, prolonged jaundice, or micropenis in boys, and requires lifelong specialist care.
2. How is the GPR161 genetic test performed and what sample is needed?
The test requires a simple blood sample, extracted DNA, or a single dried blood spot on an FTA card. Our ISO-certified home collection team collects the sample between 8 AM and 11 PM through VIP Mobile Phlebotomy, and the DNA is shipped under strict temperature-controlled cold-chain conditions to our NGS laboratory.
3. Why is a genetic counselling session recommended before testing?
A pre-test genetic counselling session draws a comprehensive family pedigree chart involving relatives affected by pituitary stalk interruption syndrome, and clarifies the implications of a positive or negative result. This ensures informed consent, psychological readiness, and accurate interpretation of the GPR161 finding within the family context.
4. What is the turnaround time for results?
Results are typically available within 3–4 weeks from sample receipt. This allows for full gene coverage, bioinformatics analysis, and variant confirmation using orthogonal methods when necessary.
5. Does insurance cover this test?
Coverage varies by insurance provider. You can verify direct billing eligibility by contacting us via WhatsApp at +971 54 548 8731 with your policy details.
UAE Regulatory & Data Privacy Adherence
Trust & Compliance Framework
All genetic data processing is conducted under the protections of Federal Decree-Law No. 45 of 2021 on Personal Data Protection (PDPL) and aligned with Federal Law No. 2 of 2019 Concerning the Use of Information and Communication Technology in Health Fields. Your genetic information is encrypted, access-restricted, and never shared without explicit patient consent as mandated by law.
Clinical safety and patient consent protocols adhere to Federal Decree-Law No. 4 of 2016 on Medical Liability. Our laboratory is ISO 9001:2015 accredited and holds DHA Facility License Number 1143.
Clinical & Logistical Metadata
| Test Name | GPR161 Gene Pituitary Stalk Interruption Syndrome (GPR161-Related) Genetic Test |
| Price (AED) | 2,800 AED |
| Turnaround Time | 3–4 Weeks |
| Sample Type / Matrix | Peripheral Whole Blood (3–5 mL in EDTA tube), Extracted DNA (≥1 µg), or Dried Blood Spot on FTA Card |
| Methodology Used | Next-Generation Sequencing (NGS) on Illumina® Platform with Sanger Confirmation for Clinically Relevant Variants |
| ICD-10-CM Code | E23.0 (Hypopituitarism), Q04.4 (Congenital malformation of brain – PSIS) |
| LOINC Code | 81247-9 (Master HL7 genetic variant reporting panel) |
| DHA Facility License & Laboratory Address | DHA Facility License Number: 1143 | Premises 105, Floor 1, Building 33, Dubai Healthcare City, Dubai, UAE | DNA Labs UAE |
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