Test Price
2,800 AED✅ Home Collection Available
DKC1 Gene Dyskeratosis Congenita, X-Linked Genetic Test in UAE | 2800 AED | DHA Licensed
Executive Summary & Core Metrics
- Accuracy Guarantee: 99.9% Diagnostic Sensitivity via ISO Accredited Processing.
- Premium Logistics: Paid Hospital-Grade VIP Mobile Phlebotomy & Temperature-Controlled Cold-Chain Home Collection (Available daily from 8 AM to 11 PM).
- Clinical Guidance: Telephonic Post-Test Clinical Guidance in result interpretation.
- Insurance: Direct Billing Verification via WhatsApp +971 54 548 8731.
Test Overview & Methodology
The DKC1 NGS test detects pathogenic variants in the DKC1 gene responsible for X-linked dyskeratosis congenita—a progressive disorder affecting skin, nails, bone marrow, and lungs. This test is critical for dermatologists, hematologist-oncologists, and clinical geneticists managing patients with suspected inherited bone marrow failure syndromes. Next-Generation Sequencing (NGS) with CNV analysis ensures comprehensive detection of single nucleotide variants, insertions/deletions, deep intronic variants, and copy number variations.
| Test Feature | DKC1 NGS (Our Test) | Sanger Sequencing (Alternative) |
|---|---|---|
| Method | Next-Generation Sequencing with CNV analysis | Sanger sequencing (exon-by-exon) |
| Variants Detected | SNVs, indels, deep intronic, CNVs | SNVs and small indels only |
| Diagnostic Sensitivity | >99.9% for coding variants | ~95% for targeted exons |
| Turnaround Time | 3 – 4 Weeks | 4 – 6 Weeks |
| Pre‑ & Post‑Test Support | Included genetic counseling session, pedigree charting, telephonic interpretation | May not be included |
Physician Insight & Safety Protocols
“As a Consultant Medical Genetics specialist, I emphasize that this comprehensive NGS analysis provides high-resolution insight into your genetic makeup. A positive result can guide family planning and early interventions, while a negative result does not exclude other genetic or acquired causes. All results must be interpreted alongside a complete clinical evaluation and pedigree analysis. Always discuss treatment decisions with your supervising specialist.”
— Lina Osama Zaki Quteineh, Consultant Medical Genetics | DHA Registration ID: 9294403
Clinical Advisory
Important Safety Information
Do not discontinue any prescribed medication without consulting your doctor. This test is for diagnostic purposes only and should not directly alter ongoing therapy without specialist advice.
For comprehensive clinical history requirements, a genetic counseling session to draw a pedigree chart of family members affected with DKC1-related dyskeratosis congenita is mandatory prior to sample collection.
Exclusion Criteria & Emergency Red Flags
Exclusion Criteria
- Patient currently in acute life‑threatening condition requiring immediate intervention
- Inability to provide informed consent
- Known severe coagulopathy (if blood draw indicated)
- Active severe infection with hemodynamic instability
Emergency Red Flags – Seek Immediate Medical Attention
- Unexplained severe bruising/bleeding
- Fever with neutropenia
- Rapidly worsening dyspnea
- Signs of bone marrow failure (extreme pallor, fatigue, recurrent infections)
- Acute pulmonary fibrosis symptoms
Patient FAQ & Clinical Guidance
1. What is the DKC1 gene test and who should consider it?
The DKC1 gene test identifies mutations causing X-linked dyskeratosis congenita, aiding diagnosis, prognosis, and family screening. It is recommended for males with nail dystrophy, skin pigmentation, oral leukoplakia, bone marrow failure, or pulmonary fibrosis; female carriers considering pregnancy; and families with a history of early-onset cancers linked to telomere biology disorders.
2. How is the test performed and what sample is required?
A simple blood draw (3–5 mL peripheral whole blood) is collected at home by a certified phlebotomist. Our VIP Mobile Phlebotomy service ensures temperature-controlled cold-chain transport from your doorstep to our ISO-certified lab. The procedure takes less than 10 minutes. Home collection is available daily from 8 AM to 11 PM.
3. Why choose DNA Labs UAE for this genetic test?
We provide ISO-certified NGS with 99.9% sensitivity, DHA supervision, and complimentary genetic counseling. Your results are interpreted by a multidisciplinary team including dermatologists, hematologists, and clinical geneticists, ensuring a holistic care plan. We adhere strictly to UAE data protection laws and international standards.
4. What is the turnaround time for results?
Results are typically available within 3 to 4 weeks from sample receipt. The detailed report includes variant interpretation, clinical significance, and recommendations for follow-up.
5. Can insurance be used to cover the test cost?
We offer direct billing verification with most major insurance providers. For a pre-authorization check, please contact us via WhatsApp at +971 54 548 8731 with your policy details.
UAE Regulatory & Data Privacy Adherence
Commitment to Data Protection
Your genetic data is protected under Federal Decree-Law No. 45 of 2021 on Personal Data Protection (PDPL) and processed exclusively within the UAE. All clinical information is handled in compliance with Federal Law No. 2 of 2019 Concerning the Use of Information and Communication Technology in Health Fields. Our laboratory holds ISO 9001:2015 certification (Cert: INT/EGQ/2509DA/3139) and is licensed under DHA Facility License No. 1143.
For direct billing and insurance support, contact us via WhatsApp: +971 54 548 8731.
Clinical & Logistical Metadata
| Test Name | DKC1 Gene Dyskeratosis Congenita, X-Linked – NGS Sequencing & CNV Analysis |
| Price (AED) | 2,800 |
| Turnaround Time | 3–4 weeks |
| Sample Type / Matrix | Peripheral whole blood (3–5 mL) in EDTA tube; Dried Blood Spot (FTA card) also accepted |
| Methodology Used | Next-Generation Sequencing (NGS) with CNV analysis |
| ICD-10-CM Code | D61.0 (Constitutional aplastic anemia) |
| LOINC Code | 21603-0 (Gene mutations detected in Blood by Sequencing) |
| DHA Facility License & Address | License No. 1143 | Premises 105, Floor 1, Building 33, Dubai Healthcare City, Dubai, UAE |
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