Test Price
2,800 AED✅ Home Collection Available
HADHA Gene Sequencing Test (LCHAD Deficiency) in UAE | 2 800 AED | DHA Licensed Facility
Executive Summary & Core Metrics
- Accuracy Guarantee: 99.9% Diagnostic Sensitivity via ISO 9001:2015 Accredited NGS Laboratory.
- Premium Logistics: VIP Mobile Phlebotomy & Temperature-Controlled Cold-Chain Home Collection (8 AM–11 PM) for blood, DNA, or FTA card.
- Clinical Guidance: Complimentary telephonic post‑test result interpretation by DHA‑licensed genetic counsellors.
- Insurance: Direct Billing Verification via WhatsApp +971 54 548 8731.
Test Overview & Methodology
The HADHA Gene Sequencing Test detects pathogenic variants in the HADHA gene responsible for Long‑chain 3‑hydroxyacyl‑CoA dehydrogenase (LCHAD) deficiency, a rare autosomal recessive disorder of mitochondrial fatty acid beta‑oxidation. This advanced Next‑Generation Sequencing (NGS) analysis provides comprehensive coverage of all coding exons, splice sites, and copy number variations, enabling definitive diagnosis and carrier screening.
Pre‑Test Requirements
- Provide a detailed clinical history of the patient.
- Mandatory pre‑genetic counselling session (in‑person or telehealth) to construct a pedigree chart of affected family members.
- No fasting required; inform the laboratory if the patient has had a blood transfusion or bone marrow transplant in the preceding two weeks.
- Accepted samples: Whole Blood (EDTA), Extracted DNA, or a drop of blood on an FTA Card.
| Feature | Our Test (HADHA NGS) | Closest Alternative (Sanger / Enzyme Assay) |
|---|---|---|
| Technology | Next‑Generation Sequencing (full gene) | Single‑gene Sanger sequencing or fibroblast enzyme assay |
| Diagnostic Sensitivity | >99.9% for SNVs, indels, and CNVs | ~85–90% if only common mutations tested |
| Turnaround Time | 3–4 Weeks | 6–8 Weeks (enzyme assay) / 3–5 Weeks (Sanger) |
| Cost | 2 800 AED | 2 500–3 500 AED |
Physician Insight & Safety Protocols
“As a Consultant Medical Genetics, I emphasise that HADHA genetic results must be interpreted in the context of clinical presentation, family history, and biochemical findings. A positive result confirms LCHAD deficiency and guides dietary management with MCT oil, emergency protocols, and cascade screening. A negative result does not exclude all metabolic disorders – always consult your metabolic specialist. Never alter or stop prescribed medications without direct physician approval.”
– Lina Osama Zaki Quteineh, Consultant Medical Genetics, DHA Registration ID: 9294403
MEDICATION WARNING
Do not discontinue any prescribed medication, including medium‑chain triglyceride (MCT) oil or carnitine supplements, without explicit consultation of your treating physician.
Exclusion Criteria & Emergency Red Flags
- Exclusion: Recent allogeneic blood transfusion (<2 weeks) may interfere with DNA integrity – use a buccal swab or FTA card as an alternative.
- Exclusion: Bone marrow transplant recipients may have chimeric DNA; a pre‑transplant sample or alternative tissue is recommended.
- Red Flag Symptoms – Seek Emergency Care: Vomiting, extreme lethargy, hypoglycemia, seizures, or sudden unresponsiveness, especially during fasting or illness; these may indicate a metabolic crisis.
Patient FAQ & Clinical Guidance
1. What does the HADHA gene sequencing test detect, and who should consider it?
This NGS test detects nearly all single nucleotide variants, insertions/deletions, and copy number changes in the HADHA gene, providing definitive diagnosis for LCHAD deficiency in symptomatic infants or confirmation in individuals with abnormal acylcarnitine profiles.
2. How is the sample collected, and does home collection meet UAE safety standards?
A DHA‑registered phlebotomist collects blood using ISO‑certified cold‑chain protocols; you may also provide a painless finger‑prick drop on an FTA card or a saliva sample, all fully compliant with UAE infection control and PDPL data privacy laws.
3. How long do results take, and will insurance cover the cost?
Final reports are delivered in 3–4 weeks through a secure patient portal; we verify your insurance coverage directly via WhatsApp at +971 54 548 8731 and offer self‑pay plans of 2 800 AED inclusive of pre‑test genetic counselling.
UAE Regulatory & Data Privacy Adherence
This diagnostic service operates in full compliance with Federal Decree-Law No. 45 of 2021 on Personal Data Protection (PDPL) and Federal Law No. 2 of 2019 Concerning the Use of Information and Communication Technology in Health Fields. All genetic data is processed in an ISO 9001:2015‑certified facility under strict confidentiality. Patient consent and clinical safety are governed by Federal Decree-Law No. 4 of 2016 on Medical Liability.
Clinical & Logistical Metadata
| Test Name | HADHA Gene Sequencing (Long‑chain 3‑hydroxyacyl‑CoA dehydrogenase deficiency) |
| Price (AED) | 2 800 AED |
| Turnaround Time | 21–28 Days |
| Sample Type / Matrix | Peripheral Whole Blood (EDTA), Extracted DNA, or Dried Blood Spot (FTA Card) |
| Methodology Used | Next‑Generation Sequencing (NGS) – full gene coding exons, splice sites, and CNV analysis |
| ICD-10-CM Code | E71.310 |
| LOINC Code | 81235-6 |
| DHA Facility License & Laboratory Address | License No. 1143 | Premises 105, Floor 1, Building 33, Dubai Healthcare City, Dubai, UAE | DNA Labs UAE |
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