Test Price
2,800 AEDโ Home Collection Available
SLC25A15 Gene HHH Syndrome NGS Sequencing Test in Dubai | 2800 AED | DHA Licensed
Executive Summary & Core Metrics
- Accuracy Guarantee: 99.9% Diagnostic Sensitivity via ISO 9001:2015 Accredited Processing and Sanger validation.
- Premium Logistics: VIP Mobile Phlebotomy & Temperature-Controlled Cold-Chain Home Collection available daily from 8 AM to 11 PM.
- Clinical Guidance: Complimentary telephonic post-test interpretation session with a DHA-licensed Consultant Medical Geneticist.
- Insurance: Direct Billing Verification via +971 54 548 8731 (WhatsApp).
Test Overview & Methodology
The SLC25A15 NGS test screens the entire gene for pathogenic variants causing hyperornithinemia-hyperammonemia-homocitrullinuria (HHH) syndrome, a rare urea cycle disorder. This test provides a definitive molecular diagnosis and enables cascade screening for at-risk family members. Next-generation sequencing targets all exons and flanking intronic regions with Sanger confirmation of all clinically significant variants, delivering 99.9% sensitivity for single nucleotide variants, small insertions, and deletions.
| Feature | Our Genetic Test | Closest Alternative โ Biochemical Panel |
|---|---|---|
| Precision / Methodology | Full gene sequencing (NGS) with Sanger verification | Plasma amino acid & ammonia quantification (HPLC/LC-MS) |
| Diagnostic Sensitivity | 99.9% for point mutations & CNVs | ~75% (requires metabolic stress; cannot identify carriers) |
| Turnaround Time | 3โ4 weeks | 5โ7 business days |
| Carrier & Prenatal Utility | Yes โ applicable to family planning | No โ cannot detect heterozygous carriers |
| Price (AED) | 2800 | 1200 |
Physician Insight & Safety Protocols
โAs your Consultant Medical Geneticist, I recognize that testing for HHH syndrome can bring anxiety. This NGS test offers clarity, but a negative result never rules out all metabolic disordersโclinical correlation is essential. Continue all prescribed therapies and consult our team before any dietary adjustments.โ โ Lina Osama Zaki Quteineh, Consultant Medical Genetics, DHA Registration ID: 9294403
Advisory โ Medication Continuity
Do not discontinue prescribed medication (e.g., ammonia scavengers, arginine) without consulting your metabolic physician. Abrupt cessation may precipitate hyperammonemic crisis.
Exclusion Criteria & Emergency Red Flags
- Exclusion: Bone marrow transplant from an allogeneic donor within 6 weeks (may yield mixed chimerism).
- Exclusion: Active hematological malignancy with circulating tumor DNA confounding results.
- Emergency Red Flag: Sudden lethargy, persistent vomiting, ataxia, or seizure โ go immediately to the emergency department.
- Emergency Red Flag: Ammonia >150 ยตmol/L (or per local lab) requires urgent medical intervention.
Patient FAQ & Clinical Guidance
1. What is the SLC25A15 gene test for HHH syndrome?
The SLC25A15 genetic test detects mutations causing hyperornithinemia-hyperammonemia-homocitrullinuria syndrome, enabling accurate diagnosis and family screening. This NGS test reads the complete gene sequence to identify single nucleotide changes as well as deletions or duplications that impair the mitochondrial ornithine transporter. A positive result confirms HHH syndrome and facilitates initiation of precision therapy, dietary management, and cascade testing of relatives.
2. How is the test performed and what sample is needed?
A simple blood draw in an EDTA tube, extracted DNA, or a one-drop blood FTA card provides sufficient material for NGS sequencing. Our phlebotomist arrives at your home within the 8 AM to 11 PM window, uses a temperature-controlled cold-chain kit, and the sample is processed in our ISO 9001:2015 accredited laboratory. No fasting or special preparation is required, and the FTA card option is ideal for infants or remote locations.
3. How long for results and what should I do after?
Results are available in 3 to 4 weeks and include a complimentary telephonic interpretation session with a Consultant Medical Geneticist. Upon report release, the physician explains the findings, their implications for your health and family, and coordinates immediate clinical management if a pathogenic variant is identified. Follow-up genetic counseling and dietary adjustments are arranged through our DHA-licensed network.
UAE Regulatory & Data Privacy Adherence
This test is performed in full compliance with Federal Decree-Law No. 45 of 2021 on Personal Data Protection (PDPL) and Federal Law No. 2 of 2019 Concerning the Use of Information and Communication Technology in Health Fields. All clinical testing safety and patient consent protocols adhere to Federal Decree-Law No. 4 of 2016 on Medical Liability. Our laboratory is ISO 9001:2015 accredited (Cert: INT/EGQ/2509DA/3139).
This test is indicated for patients referred by a Consultant Medical Geneticist, Pediatric Metabolic Specialist, or General Physician.
Clinical & Logistical Metadata
| Test Name | SLC25A15 Gene (HHH Syndrome) NGS Sequencing |
| Price (AED) | 2,800 |
| Turnaround Time | 3โ4 Weeks |
| Sample Type / Matrix | Peripheral Whole Blood (EDTA) or Dried Blood Spot (FTA Card) |
| Methodology Used | Next-Generation Sequencing (NGS) with Sanger Validation |
| ICD-10-CM Code | E72.2, E72.29 |
| LOINC Code | 55233-1 |
| DHA Facility License & Address | License No. 1143 | Premises 105, Floor 1, Building 33, Dubai Healthcare City, Dubai, UAE | DNA Labs UAE |
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