Test Price
2,800 AED✅ Home Collection Available
SLC25A15 Gene HHH Syndrome NGS Test in UAE | 2800 AED | 2026 DHA Guidelines
تحليل جين SLC25A15 لمتلازمة فرط الأورنيثين-فرط أمونيا الدم-بيلة الهوموسيترولين في الإمارات | 2800 درهم | معتمد من هيئة الصحة بدبي
Executive Summary
- Accuracy Guarantee: 99.9% Diagnostic Sensitivity via ISO 9001:2015 Accredited Processing and Sanger validation.
- Premium Logistics: Paid Hospital-Grade Home Collection via ISO Certified Cold-Chain Home Collection and VIP Mobile Phlebotomy.
- Clinical Guidance: Telephonic Post-Test Clinical Guidance in result interpretation by a DHA-licensed clinical geneticist.
- Insurance: Direct Billing Verification via +971 54 548 8731 (WhatsApp).
الموجز التنفيذي
دقة تشخيصية 99.9% عبر تحليل تسلسل الجيل التالي المعتمد وفق ISO 9001:2015. خدمة سحب منزلي فاخرة على مدار الساعة. إرشاد طبي هاتفي من أخصائي الوراثة السريرية بعد النتيجة.
تحقق مباشر من التغطية التأمينية عبر واتساب +971545488731.
Comprehensive Overview of the HHH Syndrome DNA Test
The SLC25A15 NGS test screens the entire gene for pathogenic variants causing hyperornithinemia-hyperammonemia-homocitrullinuria (HHH) syndrome, a rare urea cycle disorder. This test provides a definitive molecular diagnosis and enables cascade screening for at-risk family members.
يفحص هذا الاختبار الجيني الكامل جين SLC25A15 لتأكيد متلازمة HHH وتوجيه العلاج الغذائي الدقيق.
| Feature | Our Genetic Test | Closest Alternative – Biochemical Panel |
|---|---|---|
| Precision / Methodology | Full gene sequencing (NGS) with Sanger verification | Plasma amino acid & ammonia quantification (HPLC/LC-MS) |
| Diagnostic Sensitivity | 99.9% for point mutations & CNVs | ~75% (requires metabolic stress; cannot identify carriers) |
| Turnaround Time | 3–4 weeks | 5–7 business days |
| Carrier & Prenatal Utility | Yes – applicable to family planning | No – cannot detect heterozygous carriers |
| Price (AED) | 2800 | 1200 |
Physician Insight & Safety Protocol
“As your clinical geneticist, I recognize that testing for HHH syndrome can bring anxiety. This NGS test offers clarity, but a negative result never rules out all metabolic disorders—clinical correlation is essential. Please continue all prescribed therapies and consult our team before any dietary changes.” – Dr. PRABHAKAR REDDY, DHA 61713011
🚨 Medication Warning
Do not discontinue prescribed medication (e.g., ammonia scavengers, arginine) without consulting your metabolic physician. Abrupt cessation may precipitate hyperammonemic crisis.
Exclusion Criteria & ER Red Flags
- Exclusion: Bone marrow transplant from an allogeneic donor within 6 weeks (may yield mixed chimerism).
- Exclusion: Active hematological malignancy with circulating tumor DNA confounding results.
- ER Red Flag: Sudden lethargy, persistent vomiting, ataxia, or seizure – go immediately to the emergency department.
- ER Red Flag: Ammonia >150 µmol/L (or per local lab) requires urgent medical intervention.
Patient FAQ & Clinical Guidance
What is the SLC25A15 gene test for HHH syndrome?
The SLC25A15 genetic test detects mutations causing hyperornithinemia-hyperammonemia-homocitrullinuria syndrome, enabling accurate diagnosis and family screening. This NGS test reads the complete gene sequence to identify single nucleotide changes as well as deletions or duplications that impair the mitochondrial ornithine transporter. A positive result confirms HHH syndrome and facilitates initiation of precision therapy, dietary management, and cascade testing of relatives.
يكشف اختبار جين SLC25A15 عن الطفرات المسببة لمتلازمة فرط الأورنيثين وفرط أمونيا الدم وبيلة الهوموسيترولين، مما يتيح تشخيصًا دقيقًا وإجراء الفحوصات العائلية اللازمة.
How is the test performed and what sample is needed?
A simple blood draw in EDTA tube, extracted DNA, or a one-drop blood FTA card provides sufficient material for NGS sequencing. Our phlebotomist arrives at your home within the 8 AM – 11 PM window, uses a cold-chain kit, and the sample is processed in our ISO 9001:2015 laboratory. No fasting or special preparation is required, and the FTA card option is ideal for infants or remote locations.
يتم إجراء الاختبار من خلال سحب عينة دم بسيطة في أنبوب EDTA، أو الحمض النووي المستخلص، أو بقعة دم على بطاقة FTA، وكلها كافية للتحليل الجيني.
How long for results and what should I do after?
Results are available in 3 to 4 weeks and include a complimentary telephonic interpretation session with a clinical geneticist. Upon report release, a physician explains the findings, their implications for your health and family, and coordinates immediate clinical management if a pathogenic variant is identified. Follow-up genetic counseling and dietary adjustments are arranged through our DHA-licensed network.
تظهر النتائج خلال 3 إلى 4 أسابيع، وتشمل جلسة تفسير هاتفية مجانية مع أخصائي الوراثة السريرية لتوضيح النتائج والإجراءات اللاحقة.
This is performed in compliance with Federal Decree-Law No. 41 of 2024 (Art. 87) regarding genetic privacy and consent. Testing of minors adheres strictly to the UAE CDS Law 2026. All personal health data is processed under the UAE Personal Data Protection Law (PDPL). ISO 9001:2015 certified lab (Cert: INT/EGQ/2509DA/3139).
Indicated for patients referred by a Clinical Geneticist, Pediatric Metabolic Specialist, or General Physician. DHA Facility License: 9834453.
دعم ثنائي اللغة متاح
التحقق من التغطية التأمينية
Check Insurance Coverage Instantly
Stop the guesswork. Send a photo of your Insurance Card and Doctor's Prescription to our DHA-Certified Verification Team on WhatsApp.
توقف عن التخمين. أرسل صورة من بطاقة التأمين ووصفة الطبيب إلى فريق التحقق المعتمد من هيئة الصحة بدبي عبر الواتساب. احصل على تحديث الحالة في دقائق.
Available in Arabic, English, Hindi & Urdu
ISMS 27001:2022
ISO Accredited
HIPAA
All reports reviewed by DHA-Certified physicians