Test Price
1,500 AED✅ Home Collection Available
HHH Syndrome (Hyperornithinemia-Hyperammonemia-Homocitrullinuria) Diagnostic Test in UAE | 1500 AED | DHA Licensed
Executive Summary & Core Metrics
This quantitative urinary metabolite panel using advanced LC-MS/MS technology enables precise diagnosis of HHH syndrome, a rare urea cycle disorder. All procedures comply with UAE federal health data protection and medical liability frameworks. Results are delivered within 5 working days.
Test Overview & Methodology
The HHH Syndrome Test employs liquid chromatography-tandem mass spectrometry (LC-MS/MS) to quantify urinary ornithine, ammonia, and homocitrulline concentrations with high specificity and sensitivity. This method outperforms conventional qualitative amino acid screening by delivering precise quantitative data in μmol/L for accurate clinical decision-making.
| Feature | DNA Labs UAE HHH Test | Standard Alternative |
|---|---|---|
| Methodology | LC-MS/MS (UPLC-QqQ Tandem Mass Spectrometry) | Routine Urine Amino Acid HPLC |
| Precision | Quantitative (μmol/L) with high specificity | Semi-quantitative; may miss mild elevations |
| Turnaround Time | 5 working days (sample received by 5 PM) | 7–14 working days |
Physician Insight & Safety Protocols
"As a Consultant Medical Genetics specialist, I emphasize that this urinary metabolite panel provides critical diagnostic information for HHH syndrome, yet results must always be interpreted alongside the complete clinical picture—including dietary history, neurological status, and genetic counseling. In acute hyperammonemia presentations, emergency stabilization takes precedence over laboratory confirmation."
— Lina Osama Zaki Quteineh, Consultant Medical Genetics | DHA Registration ID: 9294403
Medication & Treatment Advisory
⚠ Important Clinical Advisory
Patients must not discontinue any prescribed therapy—including ammonia scavengers, arginine supplementation, or dietary protein restriction—without explicit consultation with their treating physician. This diagnostic test monitors metabolic control and does not replace ongoing therapeutic management.
Exclusion Criteria & Emergency Red Flags
Exclusion Criteria
- Unable to provide a clean-catch mid-stream urine sample.
- Active urinary tract infection may confound metabolite quantification.
Emergency Red Flags — Seek Immediate Care
- New-onset confusion, lethargy, vomiting, or seizures in any patient with suspected urea cycle disorder.
- Rapid neurological deterioration or ammonia levels exceeding 150 μmol/L warrant urgent hospital admission.
Patient FAQ & Clinical Guidance
1. What does this test detect and how should I prepare?
This urine panel quantifies ornithine, ammonia, and homocitrulline to confirm HHH syndrome—a rare autosomal recessive disorder affecting the urea cycle. To prepare, collect a random clean-catch urine sample (minimum 15 mL) in a sterile container without preservatives. Provide a brief clinical history including any dietary modifications or medications.
2. How long until I receive results and who interprets them?
Results are reported within 5 working days from sample receipt. A Consultant Medical Genetics specialist interprets the quantitative metabolite profile alongside your clinical presentation. A telephonic post-test consultation is provided to explain the findings and their implications.
3. Can I use insurance and is home collection available?
Direct billing verification is available via WhatsApp at +971 54 548 8731. VIP Mobile Home Collection & Temperature-Controlled Cold-Chain Logistics cover all Emirates, with samples accepted daily from 8 AM to 11 PM. Our trained collectors ensure proper handling and transport to preserve sample integrity.
UAE Regulatory & Data Privacy Adherence
DNA Labs UAE operates in full compliance with UAE federal legislative frameworks governing health data and patient privacy:
- Federal Decree-Law No. 45 of 2021 on Personal Data Protection (PDPL) — governing the collection, processing, and storage of personal health information.
- Federal Law No. 2 of 2019 Concerning the Use of Information and Communication Technology in Health Fields — regulating digital health records and telemedicine consultations.
- Federal Decree-Law No. 4 of 2016 on Medical Liability — establishing standards for clinical safety, patient consent, and professional accountability in diagnostic services.
All laboratory procedures are ISO 9001:2015 certified (Cert: INT/EGQ/2509DA/3139), ensuring international quality management standards.
Clinical & Logistical Metadata
| Test Name | HHH Syndrome (Hyperornithinemia-Hyperammonemia-Homocitrullinuria) Diagnostic Panel |
| Price (AED) | 1500 |
| Turnaround Time | 5 working days |
| Sample Type / Matrix | Urine (random clean-catch, 15 mL minimum) |
| Methodology Used | LC-MS/MS (UPLC-QqQ Tandem Mass Spectrometry) |
| ICD-10-CM Code | E72.2 (Disorders of urea cycle metabolism) |
| LOINC Code | 48796-5 (Ornithine [Moles/volume] in Urine) |
| DHA Facility License & Address | License: 1143 | Premises 105, Floor 1, Building 33, Dubai Healthcare City, Dubai, UAE | DNA Labs UAE |
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Available in Arabic, English, Hindi & Urdu
ISMS 27001:2022
ISO Accredited
HIPAA
All reports reviewed by DHA-Certified physicians