Test Price
2,800 AED✅ Home Collection Available
Isovaleric Acidemia (IVD) Gene Genetic Test in UAE | 2800 AED | DHA Licensed
Executive Summary & Core Metrics
A high-precision next-generation sequencing genetic test conducted by a DHA-licensed Consultant Medical Geneticist at DNA Labs UAE to identify pathogenic variants in the IVD gene causing isovaleric acidemia, a rare autosomal recessive organic acid disorder. The test delivers a clinically actionable report with 99.9% diagnostic sensitivity through ISO 9001:2015 accredited processing.
- Accuracy Guarantee: 99.9% Diagnostic Sensitivity via ISO 9001:2015 Accredited Processing.
- Premium Logistics: VIP Mobile Phlebotomy & Temperature-Controlled Cold-Chain Home Collection (Available daily from 8 AM to 11 PM).
- Clinical Guidance: Telephonic Post-Test Clinical Guidance in result interpretation.
- Insurance: Direct Billing Verification via WhatsApp +971 54 548 8731.
Test Overview & Methodology
The NGS-based Isovaleric Acidemia Gene Test analyses the entire IVD coding region, including intron-exon boundaries and copy number variations, to identify pathogenic variants linked to isovaleric acidemia. Next-generation sequencing is performed on the Illumina NovaSeq platform, providing comprehensive coverage of all coding exons and flanking splice sites. The resulting report is fully annotated with ACMG/AMP variant classification guidelines and delivered within 21 to 28 calendar days.
| Feature | Our NGS Gene Test | Closest Alternative (Targeted Panel) |
|---|---|---|
| Precision | Full gene sequencing with CNV detection | Limited to known hotspot mutations |
| Method | Next-Generation Sequencing (Illumina NovaSeq) | Sanger sequencing of selected exons |
| Turnaround Time | 21–28 calendar days | 2–3 weeks (may require reflex testing) |
Physician Insight & Safety Protocols
"This comprehensive genetic analysis illuminates the molecular basis of isovaleric acidemia; however, results must always be interpreted in conjunction with biochemical findings, newborn screening data, and a detailed family history. I strongly encourage every patient to remain under the care of a metabolic specialist and never alter therapy without professional review." — Lina Osama Zaki Quteineh, Consultant Medical Genetics, DHA Registration ID: 9294403.
Important Advisory
Do not discontinue prescribed medication or dietary modifications without consulting your managing metabolic physician.
Exclusion Criteria & Emergency Red Flags
- Exclusion: Individuals without a completed pre-test genetic counselling session.
- Exclusion: Minors for whom legal guardian consent has not been formally documented.
- Red Flag: New-onset lethargy, vomiting, poor feeding, seizures, hypothermia, or the characteristic "sweaty feet" odour — seek emergency care immediately.
- Red Flag: Acute metabolic decompensation indicated by hypoglycaemia or hyperammonaemia — do not wait for test results; go to the nearest emergency department.
Patient FAQ & Clinical Guidance
1. What is the Isovaleric Acidemia Gene Test?
This genetic test identifies disease-causing variants in the IVD gene responsible for isovaleric acidemia, a rare metabolic disorder detected through newborn screening. The test examines the entire coding sequence of the IVD gene using next-generation sequencing. It can confirm a biochemical diagnosis, determine carrier status, and guide family planning decisions with high confidence. The report is interpreted by a Consultant Medical Geneticist and includes ACMG/AMP variant classification, clinical correlation, and reproductive risk estimates.
2. How should I prepare for the test?
No fasting or dietary restrictions are required; however, a mandatory pre-test genetic counselling session must be completed to collect a detailed family pedigree and document informed consent. Our logistics team will guide you through the home collection process. Simply book an appointment, and a certified phlebotomist will arrive at your location with all necessary cold-chain transport materials between 8 AM and 11 PM.
3. Who should consider this genetic test?
This test is indicated for individuals with clinical or biochemical suspicion of isovaleric acidemia, including those with abnormal newborn screening results suggesting elevated isovalerylcarnitine (C5) levels. It is also recommended for carrier screening in consanguineous couples with a family history of organic acid disorders, and for prenatal diagnosis planning in affected families.
4. What are the limitations of this test?
While NGS detects >99% of coding region variants, the test may not identify deep intronic mutations, large structural rearrangements beyond the detection range, or variants in regulatory regions. In rare cases, a negative result may warrant complementary biochemical testing or whole exome sequencing. The test does not assess mitochondrial genome variants and is not a substitute for routine newborn screening.
5. How long does it take to receive results?
The standard turnaround time is 21 to 28 calendar days from sample receipt in the laboratory. Urgent or expedited processing may be available on a case-by-case basis subject to additional charges and clinical justification. Results are delivered electronically through a secure patient portal and a printed clinical report is sent to your referring physician.
UAE Regulatory & Data Privacy Adherence
This test is performed under the clinical governance of the Dubai Health Authority (DHA) and the UAE Ministry of Health and Prevention (MOHAP). All molecular genetic procedures comply with Federal Decree-Law No. 45 of 2021 on Personal Data Protection (PDPL) governing the collection, processing, and storage of genetic data. The laboratory operations adhere strictly to Federal Law No. 2 of 2019 Concerning the Use of Information and Communication Technology in Health Fields, ensuring secure electronic health records and encrypted data transmission. Clinical safety and patient consent are governed by Federal Decree-Law No. 4 of 2016 on Medical Liability. DNA Labs UAE is ISO 9001:2015 Certified (INT/EGQ/2509DA/3139). DHA Facility License: 1143.
Clinical & Logistical Metadata
| Test Name | Isovaleric Acidemia (IVD) Gene Genetic Test |
| Price (AED) | 2,800 AED |
| Turnaround Time | 21–28 calendar days |
| Sample Type / Matrix | Peripheral whole blood (EDTA) or FTA card; VIP Mobile Phlebotomy & Temperature-Controlled Cold-Chain Home Collection available daily from 8 AM to 11 PM |
| Methodology Used | Next-Generation Sequencing (Illumina NovaSeq) |
| ICD-10-CM Code | E71.110 |
| LOINC Code | 87541-2 |
| DHA Facility License & Laboratory Address | DHA Facility License #1143 — Premises 105, Floor 1, Building 33, Dubai Healthcare City, Dubai, UAE | DNA Labs UAE |
دعم ثنائي اللغة متاح
التحقق من التغطية التأمينية
Check Insurance Coverage Instantly
Stop the guesswork. Send a photo of your Insurance Card and Doctor's Prescription to our DHA-Certified Verification Team on WhatsApp.
توقف عن التخمين. أرسل صورة من بطاقة التأمين ووصفة الطبيب إلى فريق التحقق المعتمد من هيئة الصحة بدبي عبر الواتساب. احصل على تحديث الحالة في دقائق.
Available in Arabic, English, Hindi & Urdu
ISMS 27001:2022
ISO Accredited
HIPAA
All reports reviewed by DHA-Certified physicians