Test Price
2,800 AED✅ Home Collection Available
HLCS Gene Holocarboxylase Synthetase Deficiency Genetic Test in UAE | 2800 AED | DHA Licensed
Executive Summary & Core Metrics
- Accuracy Guarantee: 99.9% Diagnostic Sensitivity via ISO 9001:2015 Accredited NGS Processing.
- Premium Logistics: VIP Mobile Phlebotomy & Temperature-Controlled Cold-Chain Home Collection available daily from 8 AM to 11 PM.
- Clinical Guidance: Complimentary Post-Test Telephonic Interpretation by a DHA-licensed Clinical Geneticist.
- Insurance: Direct Billing Verification via WhatsApp +971 54 548 8731.
Test Overview & Methodology
This advanced Next-Generation Sequencing (NGS) test analyzes the entire coding region of the HLCS gene to detect pathogenic variants causing Holocarboxylase Synthetase Deficiency, a rare metabolic disorder affecting biotin utilization. The test is essential for confirmation of clinical diagnosis, carrier screening, and targeted family planning in the UAE.
| Feature | Our Test (NGS) | Closest Alternative (Sanger Sequencing) |
|---|---|---|
| Methodology | Next‑Generation Sequencing | Sanger Sequencing |
| Variant Detection Rate | >99.9% | ~95% |
| Turnaround Time | 3–4 Weeks | 6–8 Weeks |
| Cost (AED) | 2800 | ~4500 |
Physician Insight & Safety Protocols
“Holocarboxylase synthetase deficiency can present with life-threatening metabolic acidosis in newborns; however, early genetic diagnosis allows prompt biotin supplementation, which can be life-saving. This test must be interpreted alongside full clinical and biochemical evaluations – a negative result does not exclude other metabolic disorders. Our dedicated team, led by Lina Osama Zaki Quteineh (Consultant Medical Genetics, DHA ID: 9294403), ensures empathetic, comprehensive support throughout your diagnostic journey.”
Medication Advisory
⚠️ Do not discontinue any prescribed medication without consulting your doctor. High-dose biotin supplements (>30 mg/day) do not interfere with DNA testing but must be disclosed during pre-test clinical review.
Safety & Exclusion Criteria
- Exclusion Criteria: Individuals currently on high‑dose biotin therapy (≥30 mg/day) should schedule sample collection after consultation with their physician regarding appropriate timing.
- ER Red Flags: If the patient (especially an infant/child) develops sudden lethargy, projectile vomiting, seizures, or breathing difficulties, seek emergency medical care immediately – do not wait for test results.
Patient FAQ & Clinical Guidance
1. What is the purpose of the HLCS gene NGS test?
The HLCS NGS test identifies genetic mutations causing holocarboxylase synthetase deficiency, enabling early diagnosis and timely biotin treatment. It clarifies inheritance patterns and supports reproductive options for at-risk families.
2. How is the sample collected, and what types are accepted?
A whole blood sample, extracted DNA, or a single drop of blood on an FTA card is acceptable. Collection can be performed via VIP Mobile Phlebotomy and temperature-controlled cold-chain home collection, available daily from 8 AM to 11 PM.
3. How long until results, and will a doctor explain them?
Results are delivered within 3 to 4 weeks, and every report includes a complimentary telephonic clinical interpretation session with a DHA-licensed genetics specialist.
UAE Regulatory & Data Privacy Adherence
Regulatory Compliance & Data Privacy
This service strictly adheres to Federal Decree-Law No. 45 of 2021 on Personal Data Protection (PDPL) and Federal Law No. 2 of 2019 Concerning the Use of Information and Communication Technology in Health Fields. Clinical testing and patient consent comply with Federal Decree-Law No. 4 of 2016 on Medical Liability. Laboratory is DHA-licensed (Facility License: 1143) and accredited under ISO 9001:2015 (Cert: INT/EGQ/2509DA/3139). Home collection services comply with UAE cold-chain and mobile healthcare regulations.
Clinical & Logistical Metadata
| Test Name | HLCS Gene Holocarboxylase Synthetase Deficiency Genetic Test |
| Price (AED) | 2,800 AED |
| Turnaround Time | 3–4 Weeks |
| Sample Type / Matrix | Whole blood, extracted DNA, or FTA card |
| Methodology Used | Next-Generation Sequencing (NGS) |
| ICD-10-CM Code | E74.8 |
| LOINC Code | 82939-0 |
| DHA Facility License & Laboratory Address | DHA License No. 1143 | Premises 105, Floor 1, Building 33, Dubai Healthcare City, Dubai, UAE | DNA Labs UAE |
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All reports reviewed by DHA-Certified physicians