PMS2 Gene (Lynch Syndrome) Genetic Test in UAE | 2800 AED | 2026 DHA Guidelines

تحليل جين PMS2 (متلازمة لينش) في الإمارات | 2800 درهم | معتمد من هيئة الصحة بدبي

ملخص تنفيذي: اختبار الحمض النووي لجين PMS2 باستخدام التسلسل الجيني من الجيل التالي (NGS) لتقييم مخاطر متلازمة لينش (سرطان القولون الوراثي غير البوليبي من النوع الرابع) بدقة عالية ومعايير هيئة الصحة بدبي.

✔ Accuracy Guarantee: 99.9% Diagnostic Sensitivity via ISO 9001:2015 Certified Processing.
✔ Premium Logistics: Paid Hospital-Grade Home Collection via ISO Certified Cold-Chain Home Collection and VIP Mobile Phlebotomy (Blood or FTA Card).
✔ Clinical Guidance: Telephonic Post-Test Clinical Guidance in result interpretation by a genetic counselor.
✔ Insurance: Direct Billing Verification via WhatsApp +971 54 548 8731.

Comprehensive PMS2 Gene Overview (Lynch Syndrome Type 4)

This advanced genetic test employs Next-Generation Sequencing (NGS) to fully analyze the entire PMS2 gene, detecting point mutations, deletions, and duplications linked to Lynch syndrome (hereditary nonpolyposis colorectal cancer type 4). The resulting risk assessment empowers oncologists, gastroenterologists, and clinical geneticists to design personalised surveillance and prevention strategies for patients and their at‑risk relatives.

يستخدم هذا الاختبار تقنية تسلسل الحمض النووي من الجيل التالي لفحص جين PMS2 بالكامل، مما يكشف عن الطفرات المرتبطة بمتلازمة لينش ويمكّن أطباء الأورام والجهاز الهضمي من وضع خطط مراقبة ووقاية مخصصة.

Feature	Our Test (PMS2 NGS)	Closest Alternative (Single‑Site Sanger)
Methodology	NGS (Full‑Gene Sequencing + CNV)	Sanger Sequencing (Targeted Known Mutation)
Diagnostic Sensitivity	>99.9% (missense, indels, large rearrangements)	~85% (only pre‑specified variants)
Turnaround Time	3 – 4 weeks	2 – 3 weeks (limited scope)
Clinical Utility	Comprehensive Lynch syndrome type 4 risk stratification	Confirmation of known family mutation only

Physician Insight & Safety Protocol

“As a physician, I must emphasize that a PMS2 gene result must be carefully integrated with personal and family history, not interpreted in isolation. A positive mutation indicates a high lifetime risk of colorectal and other cancers, guiding intensified surveillance or prophylactic measures, but it does not mean cancer is present today. Please consult a genetic counselor or oncologist before making any clinical decisions based on this test.”

— Dr. PRABHAKAR REDDY, DHA License: 61713011

❗ Medication Warning

Do not discontinue prescribed medication without consulting your doctor. This test does not replace ongoing surveillance colonoscopies or oncological care.

Exclusion Criteria & Emergency Red Flags

Recent blood transfusion (within 2 weeks) may interfere with germline DNA analysis; please inform our team.
Active chemotherapy – consult your oncologist about optimal timing for sample collection.
If you experience sudden rectal bleeding, severe abdominal pain, or unexplained weight loss, seek immediate emergency care – these symptoms require urgent evaluation unrelated to this genetic test.

Patient FAQ & Clinical Guidance

Q: What does the PMS2 gene NGS test detect, and who should consider it?

This test sequences the entire PMS2 gene to identify inherited mutations that cause Lynch syndrome type 4, helping individuals with a strong family history of colorectal or endometrial cancer understand their risk and guide proactive screening.

يقوم هذا الاختبار بتسلسل كامل لجين PMS2 لاكتشاف الطفرات الموروثة المسؤولة عن متلازمة لينش، مما يساعد الأشخاص الذين لديهم تاريخ عائلي قوي من سرطانات القولون أو بطانة الرحم على فهم مخاطرهم والتخطيط للمراقبة المبكرة.

Q: How is the test performed, and is a blood draw always required?

You can provide a standard blood sample, extracted DNA, or a single drop of blood on an FTA card; our VIP phlebotomy team collects the sample at your home, office, or hotel across all UAE emirates.

يمكن تقديم عينة دم عادية، أو حمض نووي مستخلص، أو نقطة واحدة من الدم على بطاقة FTA؛ يقوم فريق الفصد المنزلي المتميز بجمع العينة في منزلك أو مكتبك أو فندقك في جميع إمارات الدولة.

Q: When will I receive my results, and how are they interpreted?

Results are released within 3 – 4 weeks and include a clear pathogenic classification; you are entitled to a complimentary post‑ tele‑consultation with a genetic counselor who will explain the clinical implications and next steps.

تُصدر النتائج خلال 3-4 أسابيع وتتضمن تصنيفًا واضحًا للطفرات؛ ويحق لك الحصول على استشارة هاتفية مجانية مع أخصائي الوراثة لشرح النتائج والخطوات التالية.

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