Test Price
2,800 AED✅ Home Collection Available
NOTCH2 Gene Alagille Syndrome Type 2 Genetic Test in UAE | 2800 AED | DHA-Licensed Diagnostics
Executive Summary & Core Metrics
Accuracy Guarantee: 99.9% Diagnostic Sensitivity via ISO-accredited NGS processing.
Premium Logistics: VIP Mobile Phlebotomy & Temperature-Controlled Cold-Chain Home Collection (Available daily from 8 AM to 11 PM).
Clinical Guidance: Complimentary telephonic post-test clinical correlation with DHA-licensed Consultant Medical Geneticist.
Insurance: Direct Billing Verification via WhatsApp +971 54 548 8731.
Corporate Oversight
DNA Labs UAE, operating under DHA Facility License 1143, provides this assay under the direct supervision of our Consultant Medical Geneticist, ensuring stringent quality control and actionable clinical reporting.
Test Overview & Methodology
The NOTCH2 gene Alagille syndrome type 2 Genetic Test screens the entire coding region of NOTCH2 using Next-Generation Sequencing to confirm or exclude a molecular diagnosis of Alagille syndrome, a multisystem disorder characterized by cholestasis, congenital heart defects, and characteristic facies. Early molecular confirmation enables targeted hepatology, cardiology, and nutritional interventions, significantly improving long-term clinical outcomes.
| Feature | Our NOTCH2 NGS Test (DHA-Accredited) | Closest Alternative (Conventional Sequencing) |
|---|---|---|
| Precision | Full-gene NGS with Sanger confirmation of variants; >99.9% analytical sensitivity and specificity | Single-gene Sanger; may miss deep intronic or large deletions |
| Methodology | Next-Generation Sequencing (NGS) on Illumina platform | Sanger sequencing of select exons |
| Turnaround Time | 3 to 4 weeks (with expedited options) | 6–8 weeks |
Physician Insight & Safety Protocols
“As a DHA-licensed Consultant Medical Geneticist, I recognize that pursuing a molecular diagnosis for a multisystem disorder like Alagille syndrome requires careful clinical correlation. This NOTCH2 NGS test provides the definitive genetic confirmation necessary for tailored liver, cardiac, and nutritional management. A positive result must always be interpreted within the full clinical context, and patients should never discontinue prescribed therapies without direct consultation with their treating physician.”
— Lina Osama Zaki Quteineh, Consultant Medical Genetics | DHA Registration ID: 9294403
Critical Medication Advisory
! Critical Medication Advisory
Do not discontinue any prescribed medication (e.g., ursodeoxycholic acid, fat-soluble vitamins, cardiac drugs) without consulting your doctor. This genetic test does not replace ongoing clinical management.
Exclusion Criteria & Emergency Red Flags
- Exclusion Criteria: Acute febrile illness, hemodynamic instability, inability to provide informed consent or legal guardian consent, or insufficient sample volume.
- ER Red Flags after Blood Draw: Prolonged bleeding (>10 min), rapid swelling or hematoma at puncture site, signs of local infection (redness, warmth, pus), or allergic reaction (hives, difficulty breathing). Seek emergency medical attention immediately.
Patient FAQ & Clinical Guidance
1. What is the clinical utility of the NOTCH2 genetic test?
This test detects disease-causing mutations in the NOTCH2 gene to confirm Alagille syndrome type 2, enabling precise clinical management, family counselling, and surveillance for associated complications such as cholestasis, cardiac anomalies, and vertebral defects.
2. How long will it take to receive my test results?
Results are typically available within 3 to 4 weeks from sample receipt. Optional expedited processing is available upon request and clinical justification.
3. Is this genetic test covered by UAE health insurance?
Many UAE insurance plans provide coverage for medically necessary genetic testing. Contact our support team via WhatsApp to verify direct billing eligibility and obtain pre-authorization guidance before your appointment.
4. What sample type is required for this analysis?
The preferred sample is peripheral whole blood collected in EDTA tubes (3-5 mL). Extracted genomic DNA of high quality is also accepted. The specimen should be shipped under temperature-controlled conditions to preserve nucleic acid integrity.
UAE Regulatory & Data Privacy Adherence
Your Data, Protected by Law
DNA Labs UAE strictly adheres to the federal data protection and healthcare privacy frameworks of the United Arab Emirates. All genetic testing and associated data handling are conducted in full compliance with:
- Federal Decree-Law No. 45 of 2021 on Personal Data Protection (PDPL): Governing the collection, processing, and storage of personal genomic data.
- Federal Law No. 2 of 2019 Concerning the Use of Information and Communication Technology in Health Fields: Mandating cybersecurity safeguards for electronic health records and genomic sequence data.
- Federal Decree-Law No. 4 of 2016 on Medical Liability: Ensuring informed consent, clinical safety, and patient rights throughout the diagnostic process.
Our facilities operate under DHA License 1143 and are certified under ISO 9001:2015, implementing robust access controls and encryption protocols to ensure absolute confidentiality and regulatory compliance.
Clinical & Logistical Metadata
| Test Name | NOTCH2 Gene Alagille Syndrome Type 2 Genetic Test |
| Price (AED) | 2,800 AED |
| Turnaround Time | 21-28 Days (Expedited options available) |
| Sample Type / Matrix | Peripheral Whole Blood (EDTA) or Extracted Genomic DNA |
| Methodology Used | Next-Generation Sequencing (NGS) with Sanger Confirmation |
| ICD-10-CM Code | Q44.7, Z13.89 |
| LOINC Code | 94391-3 |
| DHA Facility License & Address | Premises 105, Floor 1, Building 33, Dubai Healthcare City, Dubai, UAE | DHA License: 1143 | DNA Labs UAE |
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All reports reviewed by DHA-Certified physicians