Test Price
2,800 AED✅ Home Collection Available
NLRP3 Gene Muckle-Wells Syndrome Genetic Test in UAE | 2,800 AED
Executive Summary & Core Metrics
This certified genetic test analyzes the NLRP3 gene using next‑generation sequencing (NGS) to definitively diagnose Muckle‑Wells Syndrome (MWS), a rare autoinflammatory condition. The test is processed in an ISO‑accredited laboratory and includes pre‑test genetic counseling, a detailed pedigree chart, telephonic result interpretation, and direct insurance verification via WhatsApp.
- ✓ Diagnostic sensitivity >99.9% for single‑nucleotide variants and indels.
- ✓ VIP Mobile Phlebotomy & temperature‑controlled cold‑chain home collection, available daily from 8 AM to 11 PM.
- ✓ Post‑test telephonic clinical guidance provided by a consultant medical geneticist.
- ✓ Direct billing verification via WhatsApp: +971 54 548 8731.
Test Overview & Methodology
The NLRP3 NGS panel covers the complete coding region and splice‑site boundaries of the NLRP3 gene, enabling detection of all clinically relevant pathogenic variants associated with Muckle‑Wells Syndrome. The test is essential for confirming a clinical suspicion, guiding anti‑interleukin‑1 therapy, and providing accurate recurrence risk counseling for families.
| Feature | Our Test (NLRP3 NGS) | Closest Alternative |
|---|---|---|
| Methodology | Next‑Generation Sequencing (NGS) | Sanger sequencing (single variant only) |
| Coverage | Full gene, exons & splice sites | Limited to known hotspot mutations |
| Turnaround Time | 3–4 weeks | 4–6 weeks |
| Diagnostic Sensitivity | >99.9% for SNVs/indels | ~90% for targeted variants |
| Sample Type | Whole blood (EDTA), extracted DNA, or FTA card | Blood only |
Physician Insight & Safety Protocols
“As a consultant medical geneticist, I stress that NLRP3 gene sequencing must be interpreted alongside a comprehensive clinical evaluation and family history. A confirmed pathogenic variant supports initiation of targeted biologic therapy, while a negative result does not rule out MWS if clinical suspicion persists. Always correlate with acute‑phase reactants and inflammatory markers.”
— Ms. Lina Osama Zaki Quteineh, Consultant Medical Genetics, DHA Registration ID: 9294403
Medication Advisory
Do not discontinue prescribed corticosteroids or immunosuppressants without consulting your physician. Abrupt withdrawal can trigger severe disease flares. Always discuss any medication changes with your treating doctor before or after the test.
Exclusion Criteria & Emergency Red Flags
- If you are currently experiencing an acute febrile episode with altered consciousness, seek emergency care before proceeding with testing.
- This test is not intended for prenatal diagnosis unless preceded by explicit genetic counseling and consent under Federal Decree‑Law No. 4 of 2016 on Medical Liability.
- Minors require legal guardian consent; no sample will be processed without signed authorization.
- Inadequate or hemolyzed blood samples will be rejected; a recollection will be arranged at no extra cost.
Patient FAQ & Clinical Guidance
1. What is the purpose of the NLRP3 gene test?
Direct answer: The NLRP3 gene test definitively diagnoses Muckle‑Wells Syndrome by identifying pathogenic variants in the NLRP3 gene, enabling early initiation of life‑saving biologic therapy.
2. How should I prepare for the test, and is genetic counseling mandatory?
Direct answer: You must attend a pre‑test genetic counseling session to review your clinical history and construct a detailed pedigree chart of family members affected by NLRP3‑related symptoms. No specific dietary or medication restrictions are required.
3. Will my insurance cover the 2,800 AED cost?
Direct answer: Our dedicated billing team will verify your insurance coverage directly via WhatsApp at +971 54 548 8731. Many UAE insurers cover genetic testing when medically necessary.
4. What are the pre‑test requirements?
- Clinical history detailing onset and nature of recurring fevers, rash, joint pain, and hearing loss.
- Mandatory genetic counseling session to draw a pedigree chart of family members affected by NLRP3‑related disorders.
- Accepted samples: Whole blood (EDTA), extracted DNA, or one drop of blood on an FTA card.
UAE Regulatory & Data Privacy Adherence
Your data is protected. All genetic information is handled in strict compliance with the Federal Decree‑Law No. 45 of 2021 on Personal Data Protection (PDPL) and Federal Law No. 2 of 2019 on the use of information and communication technology in health fields. Clinical testing and patient consent follow the guidelines of Federal Decree‑Law No. 4 of 2016 on Medical Liability. Our laboratory operates under DHA Facility License No. 1143 and holds ISO 9001:2015 certification (Cert: INT/EGQ/2509DA/3139).
Clinical & Logistical Metadata
| Test Name | NLRP3 Gene Sequencing (Muckle‑Wells Syndrome) |
| Price (AED) | 2,800 |
| Turnaround Time | 3–4 weeks |
| Sample Type / Matrix | Whole blood (EDTA), extracted DNA, or FTA card |
| Methodology Used | Next‑Generation Sequencing (NGS) |
| ICD‑10‑CM Code | E85.0 (hereditary periodic fever syndrome) |
| LOINC Code | 96410‑7 (NLRP3 gene mutation analysis in blood) |
| DHA Facility License & Address | License No. 1143 | Premises 105, Floor 1, Building 33, Dubai Healthcare City, Dubai, UAE |
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التحقق من التغطية التأمينية
Check Insurance Coverage Instantly
Stop the guesswork. Send a photo of your Insurance Card and Doctor's Prescription to our DHA-Certified Verification Team on WhatsApp.
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Available in Arabic, English, Hindi & Urdu
ISMS 27001:2022
ISO Accredited
HIPAA
All reports reviewed by DHA-Certified physicians