Test Price
2,800 AED✅ Home Collection Available
MANBAL Gene (Beta-Mannosidosis) NGS Genetic Test in UAE | DNA Labs UAE
Executive Summary & Core Metrics
Accurate & Fully Supported Genetic Testing at DNA Labs UAE
✅ Accuracy Guarantee: 99.9% Diagnostic Sensitivity via ISO 15189 & CAP Accredited NGS Processing.
✅ Premium Logistics: VIP Mobile Phlebotomy & Temperature-Controlled Cold-Chain Home Collection (Available daily from 8 AM to 11 PM).
✅ Clinical Guidance: Telephonic Post-Test Clinical Guidance in result interpretation by certified genetic counsellor.
✅ Insurance: Direct Billing Verification via WhatsApp +971 54 548 8731.
Test Overview & Methodology
The MANBAL Gene NGS test screens for pathogenic variants in the MANBA gene associated with Beta-Mannosidosis, a rare autosomal recessive lysosomal storage disorder. Unlike enzymatic assays, NGS provides full gene coverage with the ability to detect point mutations, small indels, and copy number variations in a single workflow.
| Feature | Our Test – MANBAL NGS | Closest Alternative – Enzyme Assay |
|---|---|---|
| Precision / Method | 99.9% sensitivity; NGS full gene sequencing (including deep intronic regions) | ~85% sensitivity; beta-mannosidase enzyme activity in leukocytes |
| Turnaround Time | 3 to 4 Weeks | 1 to 2 Weeks |
| Clinical Utility | Confirms molecular diagnosis, carrier testing, family planning | Screening; may miss heterozygotes and some pathogenic variants |
| Price (AED) | 2,800 | ~1,500 – 2,000 |
Physician Insight & Safety Protocols
Dr. Lina Osama Zaki Quteineh (Consultant Medical Genetics, DHA Registration ID: 9294403): “Beta-Mannosidosis presents a complex diagnostic challenge due to its phenotypic variability. NGS-based sequencing of the MANBA gene offers the highest diagnostic yield for confirming the condition, identifying carriers, and informing reproductive planning. However, results must always be contextualized within the full clinical picture and family pedigree. I strongly advise all patients to undergo pre- and post-test genetic counseling to ensure complete comprehension of the implications of their results.”
Important Medication Advisory
⚠️ Medication Warning: Do not discontinue or alter any prescribed medication, enzyme replacement therapy, or dietary management plan based solely on genetic test results. Always consult your treating physician or metabolic specialist before making any changes to your clinical regimen.
Patient Safety Exclusion Criteria & Emergency Red Flags
- Whole blood samples are not accepted if the patient has received a blood transfusion within the last 4 weeks, as it may interfere with DNA extraction and analysis.
- This NGS test is not intended for emergency diagnostic use. Acute clinical deterioration requires immediate metabolic workup and symptomatic management.
- Urgent ER Warning: If the final report identifies a homozygous or compound heterozygous pathogenic variant and the patient concurrently exhibits neurological deterioration, severe hepatosplenomegaly, or respiratory distress, immediate evaluation at a center with metabolic and genetic emergency specialists is required.
Patient FAQ & Clinical Guidance
1. What specific mutations does the MANBAL NGS test detect for Beta-Mannosidosis?
This NGS panel fully sequences the MANBA gene, identifying point mutations, small insertions/deletions (indels), and copy number variations with 99.9% accuracy. This confirms or rules out Beta-Mannosidosis, enabling targeted clinical management and accurate carrier testing for family members.
2. What sample types are accepted for this genetic test in Dubai?
We accept whole blood (EDTA tube), buccal swabs, FTA cards, or previously extracted high-quality DNA. Our VIP mobile phlebotomy service can collect samples from your home in Dubai and across the UAE, ensuring proper cold-chain handling and secure transport to our CAP-accredited laboratory in Dubai Healthcare City.
3. Is genetic counseling required before undergoing MANBA gene testing?
Yes, pre-test genetic counseling is strongly recommended for all patients and is mandatory for minors under UAE Federal Law. It ensures informed consent is obtained, the family pedigree is properly documented, and the patient fully understands the potential outcomes, including carrier status and implications for family planning.
UAE Regulatory & Data Privacy Adherence
Data Privacy & Confidentiality: DNA Labs UAE strictly adheres to Federal Decree-Law No. 45 of 2021 on Personal Data Protection (PDPL) and Federal Law No. 2 of 2019 Concerning the Use of Information and Communication Technology in Health Fields. All genetic data is encrypted, access-controlled, and processed solely for diagnostic purposes.
Clinical Safety & Consent: Our laboratory practices and patient consent protocols comply with Federal Decree-Law No. 4 of 2016 on Medical Liability, ensuring the highest standards of clinical safety and patient rights.
Clinical & Logistical Metadata
| Test Name | MANBAL Gene (Beta-Mannosidosis) NGS Genetic Test |
| Price (AED) | 2,800 |
| Turnaround Time | 3 to 4 Weeks |
| Sample Type / Matrix | Whole Blood, Buccal Swab, FTA Card, or Extracted DNA |
| Methodology Used | Next-Generation Sequencing (NGS) |
| ICD-10-CM Code | E77.1 |
| LOINC Code | 83136-1 |
| DHA Facility License & Address | DHA License 1143 | Premises 105, Floor 1, Building 33, Dubai Healthcare City, Dubai, UAE | DNA Labs UAE |
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All reports reviewed by DHA-Certified physicians