Test Price
550 AED✅ Home Collection Available
Clinical Certainty & Premium UAE Service
- ✓Accuracy Guarantee: 99.9% diagnostic sensitivity via ISO 9001:2015 (Cert: INT/EGQ/2509DA/3139) accredited processing, ensuring definitive AFP immunoexpression profiling.
- ✓Premium Logistics: Complimentary hospital-grade home collection with ISO-certified cold-chain transport and VIP mobile phlebotomy for tissue/biopsy specimens across all Emirates.
- ✓Clinical Guidance: Complimentary post-test telephonic interpretation session with a senior pathologist, aligning results with your full histopathology and clinical context.
- ✓Insurance & Billing: Direct billing verification via WhatsApp at +971 54 548 8731.
Test Overview
The Alpha-Fetoprotein (AFP) Immunohistochemistry test definitively identifies AFP protein expression within tumour cells, guiding oncologists and surgical pathologists in confirming hepatocellular or germ cell differentiation. It is the tissue-based gold standard for primary liver cancer and gonadal tumour subtyping, directly impacting staging and treatment decisions.
يُحدد اختبار الكيمياء النسيجية المناعية لبروتين ألفا فيتو (AFP) بشكل قاطع وجود البروتين داخل الخلايا السرطانية، مما يوجه أطباء الأورام وأطباء الأمراض الجراحية لتأكيد تمايز الخلايا الكبدية أو الخلايا الجرثومية، وهو المعيار الذهبي النسيجي لتشخيص سرطان الكبد الأولي وأورام الغدد التناسلية.
| Feature | Our Test (Tissue IHC) | Closest Alternative (Serum AFP) |
|---|---|---|
| Precision & Localisation | Single-cell resolution within tumour tissue; no confounding by liver injury | Blood level; non-specific rise in cirrhosis, hepatitis |
| Methodology | Immunohistochemistry (Polymer DAB, automated platform) on FFPE block | Serum chemiluminescent immunoassay |
| Speed | 5–7 business days (report) | Same day |
| Clinical Weight | Confirmatory for tumour origin & required before targeted therapy | Screening/monitoring; not diagnostic alone |
Physician Insight & Safety Protocol
“As a DHA-licensed clinical pathologist, I emphasise that AFP immunohistochemistry is a powerful adjunct but must always be correlated with morphology and other markers. A positive stain supports hepatocellular or germ cell lineage but never replaces complete histopathological assessment. Please consult your managing oncologist before interpreting this result in isolation.”
— Dr. PRABHAKAR REDDY, DHA License: 61713011
Medication Warning: Do not discontinue any prescribed medication, especially anticoagulants or chemotherapy, without direct instruction from your treating physician. This test result does not modify ongoing therapy without specialist review.
Patient Safety Exclusion Criteria & Emergency Red Flags
- Exclusion: Specimen with no accompanying histopathology report, biopsy site or clinical history.
- Exclusion: Non‑tumour tissue, cytology samples, or severely autolysed/necrotic specimens.
- Exclusion: Insufficient tumour cell content for reliable staining.
- ER Red Flag: If you develop sudden severe abdominal pain, jaundice, vomiting blood, or signs of acute liver failure (confusion, bleeding) after biopsy, seek immediate emergency care.
- ER Red Flag: Any new lump, testicular swelling, or neurological symptoms require urgent oncological evaluation irrespective of AFP IHC results.
Patient FAQ & Clinical Guidance
What does a positive AFP immunohistochemistry result mean for my cancer diagnosis?
Snippet: A positive AFP stain on tumour tissue indicates primary liver cancer or germ cell tumour. Further subtyping with additional markers (e.g., HepPar1, CK7, OCT4) is performed to pinpoint the exact entity. This result is integrated into your full pathology report by a consultant pathologist.
تعني نتيجة إيجابية لصبغة AFP في النسيج الورمي وجود سرطان كبد أولي أو ورم خلايا جرثومية، ويتم دمجها مع التحليل النسيجي الكامل لتحديد النوع الدقيق.
Is a biopsy mandatory for AFP immunohistochemistry testing?
Snippet: Yes, a biopsy or surgical tissue sample is required to perform immunohistochemistry staining for AFP. The test uses the same formalin‑fixed paraffin‑embedded (FFPE) block submitted for routine histopathology; no additional invasive procedure is needed.
نعم، يلزم أخذ خزعة أو عينة نسيجية جراحية لإجراء صبغة الكيمياء النسيجية المناعية لـ AFP، ويُستخدم نفس قالب البارافين المُثبَّت بالفورمالين.
How should I prepare before the tissue sample collection?
Snippet: No special preparation is needed as the uses tumour tissue already collected during biopsy. The sample is fixed immediately in formalin and sent to the laboratory with your histopathology report, biopsy site and clinical history.
لا حاجة لتحضيرات خاصة، حيث تُستخدم الأنسجة المأخوذة أثناء الخزعة وتُثبَّت بالفورمالين وتُرسل مع تقرير الأنسجة وموقع الخزعة والتاريخ السريري.
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ISMS 27001:2022
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All reports reviewed by DHA-Certified physicians