Test Price
550 AEDโ Home Collection Available
Alpha-Fetoprotein (AFP) Immunohistochemistry Test โ DNA Labs UAE
Executive Summary & Core Metrics
Clinical Certainty & Premium UAE Service
- โAccuracy Guarantee: 99.9% diagnostic sensitivity via ISO 9001:2015 (Cert: INT/EGQ/2509DA/3139) accredited processing, ensuring definitive AFP immunoexpression profiling.
- โPremium Logistics: Secure Medical Courier Solid Tissue Specimen Retrieval โ we arrange pickup of your archived FFPE block from your referring hospital or clinic across all Emirates.
- โClinical Guidance: Complimentary post-test telephonic interpretation session with a senior pathologist, aligning results with your full histopathology and clinical context.
- โInsurance & Billing: Direct billing verification via WhatsApp at +971 54 548 8731.
Test Overview & Methodology
The Alpha-Fetoprotein (AFP) Immunohistochemistry test definitively identifies AFP protein expression within tumour cells, guiding oncologists and surgical pathologists in confirming hepatocellular or germ cell differentiation. It is the tissue-based gold standard for primary liver cancer and gonadal tumour subtyping, directly impacting staging and treatment decisions.
| Feature | Our Test (Tissue IHC) | Closest Alternative (Serum AFP) |
|---|---|---|
| Precision & Localisation | Single-cell resolution within tumour tissue; no confounding by liver injury | Blood level; non-specific rise in cirrhosis, hepatitis |
| Methodology | Immunohistochemistry (Polymer DAB, automated platform) on FFPE block | Serum chemiluminescent immunoassay |
| Speed | 5โ7 business days (report) | Same day |
| Clinical Weight | Confirmatory for tumour origin & required before targeted therapy | Screening/monitoring; not diagnostic alone |
Physician Insight & Safety Protocols
โAs a DHA-licensed specialist in diagnostic radiology, I emphasize that AFP immunohistochemistry is a powerful diagnostic adjunct but must always be correlated with histomorphology and a complete panel of markers. A positive stain supports hepatocellular or germ cell lineage but should never replace comprehensive histopathological assessment. Always discuss results with your managing oncologist before making treatment decisions.โ
โ Mr. Prabhakar Reddy Kalathoor, Specialist Diagnostic Radiology, DHA License: 61713011
Medication Warning & Safety Advisory
Do not discontinue any prescribed medication, especially anticoagulants or chemotherapy, without direct instruction from your treating physician. This test result does not modify ongoing therapy without specialist review. If you experience severe abdominal pain, jaundice, or signs of acute liver failure, seek emergency care immediately.
Patient Exclusion Criteria & Emergency Red Flags
- Exclusion: Specimen with no accompanying histopathology report, biopsy site or clinical history.
- Exclusion: Nonโtumour tissue, cytology samples, or severely autolysed/necrotic specimens.
- Exclusion: Insufficient tumour cell content for reliable staining.
- ER Red Flag: If you develop sudden severe abdominal pain, jaundice, vomiting blood, or signs of acute liver failure (confusion, bleeding) after biopsy, seek immediate emergency care.
- ER Red Flag: Any new lump, testicular swelling, or neurological symptoms require urgent oncological evaluation irrespective of AFP IHC results.
Patient FAQ & Clinical Guidance
1. What does a positive AFP immunohistochemistry result mean for my cancer diagnosis?
A positive AFP stain on tumour tissue indicates primary liver cancer or a germ cell tumour. Further subtyping with additional markers (e.g., HepPar1, CK7, OCT4) is performed to pinpoint the exact entity. This result is integrated into your full pathology report by a consultant pathologist. Always correlate with morphology and clinical history.
2. Is a biopsy mandatory for AFP immunohistochemistry testing?
Yes, a biopsy or surgical tissue sample is required to perform immunohistochemistry staining for AFP. The test uses the same formalin-fixed paraffin-embedded (FFPE) block submitted for routine histopathology; no additional invasive procedure is needed. Our medical courier can retrieve the archived block from your hospital.
3. How should I prepare before the tissue sample collection?
No special preparation is needed as the test uses tumour tissue already collected during biopsy or surgery. The sample is fixed immediately in formalin and processed. Ensure your managing physician has provided a complete histopathology report, biopsy site details, and clinical history. The laboratory does not require any additional patient preparation.
UAE Regulatory & Data Privacy Adherence
DNA Labs UAE operates under DHA Facility License No: 1143 and complies fully with Federal Decree-Law No. 45 of 2021 on Personal Data Protection (PDPL) and Federal Law No. 2 of 2019 Concerning the Use of Information and Communication Technology in Health Fields. All patient data and test results are encrypted and handled in accordance with UAE federal law. Clinical safety and patient consent adhere to Federal Decree-Law No. 4 of 2016 on Medical Liability. Your tissue sample and associated data are processed with the highest standards of privacy and security.
Clinical & Logistical Metadata
| Test Name | Alpha-Fetoprotein (AFP) Immunohistochemistry |
| Price (AED) | 550 AED |
| Turnaround Time | 5โ7 Business Days |
| Sample Type / Matrix | Formalin-Fixed Paraffin-Embedded (FFPE) Tissue Block |
| Methodology Used | Immunohistochemistry (Polymer DAB, Automated Platform) |
| ICD-10-CM Code | C22.0 (Hepatocellular Carcinoma) |
| LOINC Code | 31998-0 (Alpha fetoprotein [Presence] in Tissue by Immune stain) |
| DHA Facility License & Laboratory Address | DHA License No: 1143 | DNA Labs UAE, Premises 105, Floor 1, Building 33, Dubai Healthcare City, Dubai, UAE |
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