Test Price
1,700 AED✅ Home Collection Available
Lynch Syndrome Mismatch Repair (MMR) IHC Panel in UAE | 1700 AED | DHA Licensed
Executive Summary & Core Metrics
Targeted Immunohistochemistry for Lynch Syndrome Risk Stratification
Our MMR IHC Panel assesses MLH1, MSH2, MSH6, and PMS2 protein expression in formalin-fixed paraffin-embedded (FFPE) tumor tissue. Processing takes place at our DHA-licensed Dubai laboratory (Facility License 1143) under ISO 9001:2015 standards. Results are delivered within 8 working days at a fixed cost of 1700 AED. This test is indicated for patients with colorectal or endometrial cancer who meet revised Bethesda guidelines for hereditary cancer screening.
- Specimen Logistics: Secure Medical Courier Solid Tissue Specimen Retrieval – FFPE blocks are collected from referring hospitals or clinics via temperature-controlled transport. Home phlebotomy is not applicable for this tissue-based assay.
- Clinical Guidance: Complimentary telephonic post-test interpretation with an oncology-specialist physician (by appointment).
- Insurance Support: Direct billing verification via WhatsApp at +971 54 548 8731. We coordinate with all major UAE insurers.
Test Overview & Methodology
The MMR IHC panel uses monoclonal antibodies directed against the four mismatch repair proteins. Loss of nuclear expression in tumor cells indicates deficiency and suggests Lynch syndrome. This technique complements microsatellite instability (MSI) testing and is widely endorsed by international oncology guidelines for its high sensitivity and tissue-sparing workflow.
| Feature | Our Lynch MMR IHC Panel | Alternative (MSI-PCR / NGS) |
|---|---|---|
| Methodology | Immunohistochemistry (monoclonal antibodies) | Fragment analysis or next-generation sequencing |
| Clinical Sensitivity | 99.9% for MMR deficiency | ~95% (MSI-PCR); NGS may miss epigenetic silencing |
| Turnaround Time | 8 working days | 10–14 working days |
| Cost (UAE) | 1700 AED | 2200–3500 AED |
| Pre-test Requirement | FFPE tumor biopsy block (no fasting/medication restriction) | Blood or additional tissue, often with germline consent |
Physician Insight & Safety Protocols
“An abnormal MMR IHC result is a valuable clue but not a standalone diagnosis. The absence of MLH1, MSH2, MSH6, or PMS2 staining should prompt confirmatory germline testing and genetic counseling. This test empowers physicians to implement tailored surveillance programs for at-risk individuals and their families.”
— Mr. Prabhakar Reddy Kalathoor, Specialist Diagnostic Radiology, DHA Registration ID: 61713011
Clinical Advisory – Test Interpretation Precautions
⚠️ Important Consideration
This MMR IHC panel is designed for risk stratification in the context of hereditary cancer syndromes. It does not replace genetic counseling, and a positive result should not be used as the sole basis for surgical or chemotherapeutic decisions without further molecular confirmation.
Exclusion Criteria & Emergency Referral Indicators
Contraindications and Safety Red Flags
- Exclusion Criteria: Inadequate or degraded FFPE tissue (e.g., overfixation, necrosis), insufficient tumor cellularity (<50%), or lack of informed consent as per Federal Decree-Law No. 4 of 2016 on Medical Liability.
- Emergency Red Flags: Acute abdominal pain, melena, hematochezia, or suspected bowel perforation require immediate emergency department evaluation. This elective test is not a substitute for acute care.
Patient FAQ & Clinical Guidance
1. Is a biopsy always necessary for this Lynch IHC test?
Yes, the test requires a formalin-fixed paraffin-embedded (FFPE) tumor biopsy block. The IHC technique measures protein expression directly within cancer tissue, so a representative tumor specimen is mandatory.
2. How long will my results take, and how will I receive them?
Results are released within 8 working days. They are securely delivered through your patient portal, and a complimentary telephonic interpretation session with a specialist is available on request.
3. Does a positive IHC result mean I have Lynch syndrome?
Loss of an MMR protein suggests a high probability of a germline mutation in the corresponding gene. However, definitive diagnosis requires confirmatory genetic testing (e.g., MLPA, NGS) and consultation with a genetic counselor.
UAE Regulatory & Data Privacy Adherence
Compliance with UAE Health Data Protection Frameworks
This laboratory service operates under the regulatory oversight of the Dubai Health Authority (DHA) and adheres to:
- Federal Decree-Law No. 45 of 2021 on Personal Data Protection (PDPL) – ensuring the confidentiality and security of your health information at all stages of processing.
- Federal Law No. 2 of 2019 Concerning the Use of Information and Communication Technology in Health Fields – governing the safe handling of electronic health records and telemedicine communications.
- Federal Decree-Law No. 4 of 2016 on Medical Liability – defining the standards of care and accountability for diagnostic accuracy and patient consent.
Our laboratory holds ISO 9001:2015 certification (Cert: INT/EGQ/2509DA/3139) and operates under DHA Facility License Number 1143. For any privacy concerns or data access requests, contact our Data Protection Officer via WhatsApp +971 54 548 8731.
Clinical & Logistical Metadata
| Test Name | Lynch Syndrome Mismatch Repair (MMR) IHC Panel |
| Price (AED) | 1700 AED |
| Turnaround Time | 8 working days |
| Sample Type / Matrix | Formalin-Fixed Paraffin-Embedded (FFPE) Tumor Tissue Block – Archival Specimen |
| Methodology Used | Immunohistochemistry (monoclonal antibodies against MLH1, MSH2, MSH6, PMS2) |
| ICD-10-CM Code | Z15.09 (Genetic susceptibility to other malignant neoplasm), Z80.0 (Family history of malignant neoplasm of digestive organs) |
| LOINC Code | 83521-0 (Lynch syndrome IHC panel) |
| DHA Facility License & Address | License: 1143 – Premises 105, Floor 1, Building 33, Dubai Healthcare City, Dubai, UAE – DNA Labs UAE |
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