Test Price
2,500 AED✅ Home Collection Available
Microsatellite Instability (MSI) IHC Test in UAE | 2500 AED | DHA Guidelines
Executive Summary & Core Metrics
- Accuracy Guarantee: 99.9% Diagnostic Sensitivity via ISO 9001:2015 Accredited Processing (Cert: INT/EGQ/2509DA/3139).
- Secure Medical Courier Solid Tissue Specimen Retrieval: Your archived FFPE tissue block is collected directly from your pathology facility via temperature-controlled courier; no patient travel required.
- Clinical Guidance: Telephonic Post-Test Clinical Guidance for result interpretation by DHA-licensed professionals.
- Insurance & Billing: Direct Billing Verification via WhatsApp +971 54 548 8731.
Test Overview & Methodology
This immunohistochemistry test detects loss of DNA mismatch repair proteins (MLH1, MSH2, MSH6, PMS2) on FFPE tumor tissue, guiding immunotherapy eligibility (e.g., pembrolizumab) and Lynch syndrome screening. The assay is fully automated using monoclonal antibodies and is interpreted by DHA‑licensed pathologists.
| Feature | Our Test (IHC on FFPE) | Closest Alternative (PCR‑based MSI) |
|---|---|---|
| Precision | 99.9% diagnostic sensitivity for MMR protein loss | ~95‑98% sensitivity; may miss some MSI‑H cases |
| Methodology | Fully automated IHC with monoclonal antibodies (MLH1, MSH2, MSH6, PMS2) | Fluorescent multiplex PCR fragment analysis (requires matched normal DNA) |
| Turnaround | 10 working days | 14‑21 working days |
Physician Insight & Safety Protocols
– Mr. Prabhakar Reddy Kalathoor, DHA License 61713011
Advisory: Medication & Treatment Continuity
Do not discontinue any prescribed medication (including chemotherapy, immunotherapy, or hormones) without consulting your physician. This test result does not override current treatment plans. All clinical decisions must comply with Federal Decree-Law No. 4 of 2016 on Medical Liability.
Exclusion Criteria & Safety Red Flags
- Exclusion Criteria: Insufficient tumor cellularity, extensive necrosis, decalcified bone specimens, or improper formalin fixation may yield inconclusive IHC results. Repeat biopsy may be required.
- Emergency Red Flags: If you experience uncontrolled bleeding, severe pain, fever >38.5°C, or signs of infection at the biopsy site, seek immediate emergency medical attention.
Patient FAQ & Clinical Guidance
1. What is the Microsatellite Instability (MSI) IHC test used for?
The MSI IHC test definitively identifies mismatch repair protein deficiency in tumor tissue, directly guiding eligibility for immune checkpoint inhibitors and Lynch syndrome screening. This test is the standard‑of‑care first‑line assay for colorectal, endometrial, and other solid tumors where MSI status informs prognosis and therapy. Results are reported as MSI‑High (MSI‑H) or microsatellite stable (MSS) based on the pattern of protein loss.
2. What type of sample is required and how is the test performed?
A formalin‑fixed paraffin‑embedded (FFPE) tissue block from a core biopsy or surgical resection is required; the laboratory stains sections with monoclonal antibodies against MLH1, MSH2, MSH6, and PMS2 proteins. Our secure medical courier retrieves the block directly from your pathology archive with a signed release, eliminating patient travel. The IHC process is fully automated and interpreted by DHA‑licensed pathologists.
3. How long does it take to get results and what is the accuracy?
Results are available within 10 working days. The test offers 99.9% diagnostic sensitivity when performed in an accredited laboratory under DHA guidelines. The report is sent directly to your treating physician with the option of a telephonic consultation for result interpretation. Note that test accuracy depends on tissue sample quality and absence of extensive necrosis.
UAE Regulatory & Data Privacy Adherence
This test is performed at a DHA-licensed facility (License 1143) in full compliance with Federal Decree-Law No. 45 of 2021 on Personal Data Protection (PDPL) and Federal Law No. 2 of 2019 Concerning the Use of Information and Communication Technology in Health Fields. All patient data are encrypted and handled in accordance with UAE health information privacy standards.
DNA Labs UAE – DHA Facility License 1143 | Premises 105, Floor 1, Building 33, Dubai Healthcare City, Dubai, UAE.
Clinical & Logistical Metadata
| Test Name | Microsatellite Instability (MSI) IHC Test |
| Price (AED) | 2,500 AED |
| Turnaround Time | 10 working days |
| Sample Type / Matrix | FFPE Tissue Block (Archival Solid Tissue Specimen) |
| Methodology Used | Automated Immunohistochemistry (IHC) – Monoclonal Antibodies: MLH1, MSH2, MSH6, PMS2 |
| ICD-10-CM Code | C18.9 (Malignant neoplasm of colon, unspecified) |
| LOINC Code | 21772-6 (Microsatellite instability [Interpretation] in Tumor tissue) |
| DHA Facility License & Laboratory Address | License 1143 | Premises 105, Floor 1, Building 33, Dubai Healthcare City, Dubai, UAE |
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