Test Price
480 AED✅ Home Collection Available
p40 (ΔNp63) Immunohistochemistry Test in Dubai | 480 AED | DHA-Approved
Executive Summary & Core Metrics
This DHA-approved test detects the ΔNp63 isoform of p40 with high specificity, enabling accurate differentiation of squamous cell carcinoma from adenocarcinoma in lung and head/neck biopsies. Results are integrated with histomorphology and imaging for precision oncology.
Test Overview & Methodology
The p40 (ΔNp63) immunohistochemistry test is a highly specific tissue-based stain used to confirm squamous differentiation. The assay employs a monoclonal antibody targeting the p40 protein exclusive to the ΔNp63 isoform. This method reduces misclassification compared to broader p63 staining and is the gold standard for lung cancer subtyping. The test is performed on formalin-fixed paraffin-embedded (FFPE) tissue blocks or unstained slides.
| Feature | Our p40 IHC Test | Closest Alternative (p63 IHC) |
|---|---|---|
| Precision / Specificity | High specificity for squamous differentiation (ΔNp63 isoform) | Broader reactivity; may stain non-squamous tissues |
| Methodology | Monoclonal antibody to p40 protein, validated IHC protocol (LC‑MS/MS cross‑verified) | Standard IHC using anti-p63 antibody |
| Turnaround Time | FFPE Block: 5 days Large Complex Tissue: 7 days | Typically 4–6 days |
| Clinical Utility | Gold standard in lung cancer subtyping, reduces misclassification | Useful but less definitive; requires additional markers |
Physician Insight & Safety Protocols
“In my practice, p40 immunohistochemistry is essential for confidently distinguishing squamous cell carcinoma from adenocarcinoma, particularly in lung biopsies. This test must always be correlated with histomorphology and clinical imaging—never in isolation. Please consult your oncologist to integrate these results into your personalized treatment plan.”
— Mr. Prabhakar Reddy Kalathoor, Specialist Diagnostic Radiology, DHA Registration ID: 61713011
Medication Advisory
⚠️ Do not discontinue any prescribed medication without consulting your doctor. Inform your oncologist about all current medications prior to test result interpretation.
Patient Exclusion & Safety Criteria
Exclusion Criteria: Active infection at biopsy site, severe coagulation disorders, or pregnancy without risk assessment. This test uses already collected tissue; no additional invasive procedure is required.
Emergency Red Flags: Sudden severe pain, active bleeding, breathlessness, or fever after biopsy—seek emergency medical attention immediately.
Patient FAQ & Clinical Guidance
1. What is p40 immunohistochemistry and why is it ordered?
Snippet: p40 IHC is a tissue stain that identifies squamous cell carcinomas by detecting the ΔNp63 protein. It is ordered to differentiate squamous cell carcinoma from adenocarcinoma, especially in lung and head/neck tumors, guiding targeted therapy.
2. How should I prepare for the p40 immunohistochemistry test?
Snippet: No patient preparation is required. The test uses a previously collected biopsy tissue sample (FFPE block or unstained slides) submitted by your hospital.
3. What do the results of a positive p40 mean?
Snippet: A positive p40 stain confirms squamous cell differentiation, supporting a diagnosis of squamous cell carcinoma. This result helps your oncologist select appropriate therapies and predict prognosis.
UAE Regulatory & Data Privacy Adherence
This test is performed in full compliance with UAE Federal Decree-Law No. 45 of 2021 on Personal Data Protection (PDPL) and Federal Law No. 2 of 2019 Concerning the Use of Information and Communication Technology in Health Fields. Patient data is encrypted and processed under strict confidentiality. Clinical safety and informed consent adhere to Federal Decree-Law No. 4 of 2016 on Medical Liability. All procedures follow DHA standards and ISO 9001:2015 quality management.
Clinical & Logistical Metadata
| Test Name | p40 (ΔNp63) Immunohistochemistry |
| Price (AED) | 480 AED |
| Turnaround Time | 5–7 business days (FFPE block) |
| Sample Type / Matrix | Archival Tissue Specimen (FFPE block or unstained slides) |
| Methodology Used | Immunohistochemistry (IHC) using monoclonal anti-p40 (ΔNp63) antibody, validated per ISO 9001:2015 |
| ICD-10-CM Code | C34.90, C34.1, Z15.09 |
| LOINC Code | 83077-8 |
| DHA Facility License & Laboratory Address | DHA License No: 1143 Premises 105, Floor 1, Building 33, Dubai Healthcare City, Dubai, UAE |
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