Test Price
550 AED✅ Home Collection Available
Myogenin Immunohistochemistry (IHC) Test in UAE – Definitive Rhabdomyosarcoma Subtyping
Executive Summary & Core Metrics
- 99.9% Diagnostic Sensitivity via ISO 9001:2015 accredited immunohistochemistry platform (Cert: INT/EGQ/2509DA/3139).
- Secure Medical Courier Solid Tissue Specimen Retrieval – existing FFPE block collected from your treating hospital; no new invasive procedure required.
- Post-Test Clinical Guidance – complimentary telephonic interpretation with a specialist radiologist experienced in sarcoma diagnostics.
- Direct Insurance Billing Verification via WhatsApp +971 54 548 8731.
Test Overview & Methodology
Myogenin IHC is a definitive immunohistochemical stain that detects myogenin protein in formalin-fixed paraffin-embedded (FFPE) tumor tissue. This assay is essential for confirming rhabdomyosarcoma differentiation, distinguishing embryonal from alveolar subtypes, and guiding oncologic surgery and targeted therapy decisions. The test employs a validated single-antibody clone (F5D) on an automated staining platform with heat-induced epitope retrieval and DAB chromogen detection.
| Feature | Our Myogenin IHC Test | Closest Alternative (Generic IHC Panel) |
|---|---|---|
| Precision | Single-antibody clone (F5D) validated for high specificity; automated staining platform with onboard controls | Polyclonal antibody mix; manual scoring may introduce inter-observer variability |
| Methodology | FDA-cleared IHC with heat-induced epitope retrieval, DAB chromogen, and automated interpretation algorithm | Manual IHC without on-board validation or standardized scoring |
| Turnaround | 5 working days from receipt of FFPE block; expedited 3-day option available | 7–10 working days |
Physician Insight & Safety Protocols
“As a DHA-licensed specialist in diagnostic radiology (DHA Registration ID: 61713011), I understand the anxiety a cancer workup brings. This myogenin stain, when interpreted alongside histomorphology and other myogenic markers, provides the molecular precision needed for confident treatment planning. Please remember, tissue results must always be correlated with the full clinical picture and imaging findings.” – Mr. Prabhakar Reddy Kalathoor, Specialist Diagnostic Radiology
⚠️ Advisory – Medication Continuation
Do not discontinue any prescribed medication, including chemotherapy or targeted therapy, without explicit direction from your treating oncologist. This diagnostic test provides additional molecular information and is not a substitute for ongoing clinical management.
Exclusion Criteria & Emergency Red Flags
- No FFPE block available or inadequate tumoral cellularity (<100 viable tumor cells) — test cannot be performed; a repeat biopsy may be required.
- Active bleeding at previous biopsy site, uncontrolled infection, or severe pain not manageable at home — seek immediate emergency medical attention.
- Reported result discordant with other sarcomeric markers (desmin, MyoD1, actin) — requires urgent multidisciplinary tumor board review before treatment decisions.
Patient FAQ & Clinical Guidance
1. Why do I need a myogenin IHC test if I already had a biopsy?
A standard biopsy diagnosis cannot reliably distinguish embryonal from alveolar rhabdomyosarcoma — myogenin nuclear staining provides the definitive subtype differentiation. Myogenin is a transcription factor expressed exclusively in committed skeletal muscle cells; its detection confirms rhabdomyosarcoma lineage and drives risk-adapted therapy protocols including chemotherapy intensity and surgical planning.
2. Will the test require a new procedure or cause pain?
No additional invasive procedure is needed — the test uses the same FFPE tissue block from your original diagnostic biopsy. The archived tissue is sectioned and stained in the laboratory; you will not feel anything. If the original block is unavailable or exhausted, a new biopsy may be discussed, but our pathologist first reviews all existing archival material to avoid repeat intervention.
3. How do I interpret my result and what are the next steps?
A positive result (diffuse nuclear staining) indicates skeletal muscle differentiation consistent with rhabdomyosarcoma; negative staining effectively rules out rhabdomyosarcoma but may necessitate additional immunohistochemical markers. Your oncologist will integrate this finding with imaging studies, molecular fusion gene testing (e.g., PAX3/7-FOXO1), and clinical staging to finalize a personalized treatment plan. A complimentary telephonic consultation with our specialist is available to discuss result implications.
UAE Regulatory & Data Privacy Adherence
All diagnostic procedures and data handling are fully compliant with Federal Decree-Law No. 45 of 2021 on Personal Data Protection (PDPL) and Federal Law No. 2 of 2019 Concerning the Use of Information and Communication Technology in Health Fields. Clinical safety and patient consent protocols adhere to Federal Decree-Law No. 4 of 2016 on Medical Liability. The processing laboratory holds ISO 9001:2015 certification (Cert: INT/EGQ/2509DA/3139). Medical records are encrypted and handled exclusively within UAE healthcare data sovereignty frameworks.
Clinical & Logistical Metadata
| Test Name | Myogenin Immunohistochemistry (IHC) |
| Price (AED) | 550 |
| Turnaround Time | 5 working days (expedited 3-day option available) |
| Sample Type / Matrix | Formalin-Fixed Paraffin-Embedded (FFPE) Tissue Block – Archival Specimen |
| Methodology Used | FDA-cleared automated IHC with heat-induced epitope retrieval, DAB chromogen, F5D monoclonal antibody clone |
| ICD-10-CM Code | C49.9 (Malignant neoplasm of connective and soft tissue, unspecified) |
| LOINC Code | 94497-8 (Myogenin [Presence] in Tissue by Immunohistochemistry) |
| DHA Facility License & Laboratory Address | DHA Facility License Number: 1143 | Premises 105, Floor 1, Building 33, Dubai Healthcare City, Dubai, UAE | DNA Labs UAE |
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